Glutathione Peroxidase 1 (GPX1)
GSHPX1; Cellular glutathione peroxidase
Glutathione peroxidase is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. The biochemical function of glutathione peroxidase is to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water.There are several isozymes encoded by different genes, which vary in celullar location and substrate specificity.
Glutathione peroxidase 1 is the most abundant version, found in the cytoplasm of nearly all mammalian tissues, whose preferred substrate is hydrogen peroxide.Glutathione peroxidase is a selenium-containing tetrameric glycoprotein, that is, a molecule with four selenocysteine amino acid residues.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW468Hu01 | Recombinant Glutathione Peroxidase 1 (GPX1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW468Hu01 | Monoclonal Antibody to Glutathione Peroxidase 1 (GPX1) | WB; IHC; ICC; IP. |
| PAW468Hu01 | Polyclonal Antibody to Glutathione Peroxidase 1 (GPX1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW468Hu01 | CLIA Kit for Glutathione Peroxidase 1 (GPX1) | CLIA assay for Antigen Detection |
| ELW468Hu01 | ELISA Kit for Glutathione Peroxidase 1 (GPX1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW468Mu01 | Recombinant Glutathione Peroxidase 1 (GPX1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW468Mu01 | Monoclonal Antibody to Glutathione Peroxidase 1 (GPX1) | WB; IHC; ICC; IP. |
| PAW468Mu01 | Polyclonal Antibody to Glutathione Peroxidase 1 (GPX1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW468Mu01 | CLIA Kit for Glutathione Peroxidase 1 (GPX1) | CLIA assay for Antigen Detection |
| ELW468Mu01 | ELISA Kit for Glutathione Peroxidase 1 (GPX1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW468Ra01 | Recombinant Glutathione Peroxidase 1 (GPX1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW468Ra01 | Monoclonal Antibody to Glutathione Peroxidase 1 (GPX1) | WB; IHC; ICC; IP. |
| PAW468Ra01 | Polyclonal Antibody to Glutathione Peroxidase 1 (GPX1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW468Ra01 | CLIA Kit for Glutathione Peroxidase 1 (GPX1) | CLIA assay for Antigen Detection |
| ELW468Ra01 | ELISA Kit for Glutathione Peroxidase 1 (GPX1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW468Ca01 | Recombinant Glutathione Peroxidase 1 (GPX1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW468Ca01 | Monoclonal Antibody to Glutathione Peroxidase 1 (GPX1) | WB; IHC; ICC; IP. |
| PAW468Ca01 | Polyclonal Antibody to Glutathione Peroxidase 1 (GPX1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW468Ca01 | CLIA Kit for Glutathione Peroxidase 1 (GPX1) | CLIA assay for Antigen Detection |
| ELW468Ca01 | ELISA Kit for Glutathione Peroxidase 1 (GPX1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW468Po01 | Recombinant Glutathione Peroxidase 1 (GPX1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW468Po01 | Monoclonal Antibody to Glutathione Peroxidase 1 (GPX1) | WB; IHC; ICC; IP. |
| PAW468Po01 | Polyclonal Antibody to Glutathione Peroxidase 1 (GPX1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW468Po01 | CLIA Kit for Glutathione Peroxidase 1 (GPX1) | CLIA assay for Antigen Detection |
| ELW468Po01 | ELISA Kit for Glutathione Peroxidase 1 (GPX1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW468Bo01 | Recombinant Glutathione Peroxidase 1 (GPX1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW468Bo01 | Monoclonal Antibody to Glutathione Peroxidase 1 (GPX1) | WB; IHC; ICC; IP. |
| PAW468Bo01 | Polyclonal Antibody to Glutathione Peroxidase 1 (GPX1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW468Bo01 | CLIA Kit for Glutathione Peroxidase 1 (GPX1) | CLIA assay for Antigen Detection |
| ELW468Bo01 | ELISA Kit for Glutathione Peroxidase 1 (GPX1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW468Rb01 | Recombinant Glutathione Peroxidase 1 (GPX1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW468Rb01 | Monoclonal Antibody to Glutathione Peroxidase 1 (GPX1) | WB; IHC; ICC; IP. |
| PAW468Rb01 | Polyclonal Antibody to Glutathione Peroxidase 1 (GPX1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW468Rb01 | CLIA Kit for Glutathione Peroxidase 1 (GPX1) | CLIA assay for Antigen Detection |
| ELW468Rb01 | ELISA Kit for Glutathione Peroxidase 1 (GPX1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW468Mo01 | Recombinant Glutathione Peroxidase 1 (GPX1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW468Mo01 | Monoclonal Antibody to Glutathione Peroxidase 1 (GPX1) | WB; IHC; ICC; IP. |
| PAW468Mo01 | Polyclonal Antibody to Glutathione Peroxidase 1 (GPX1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW468Mo01 | CLIA Kit for Glutathione Peroxidase 1 (GPX1) | CLIA assay for Antigen Detection |
| ELW468Mo01 | ELISA Kit for Glutathione Peroxidase 1 (GPX1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"cDNA sequence coding for human glutathione peroxidase."
Nucleic Acids Res. 15:7178-7178(1987) [PubMed] [Europe PMC] [Abstract]
"Nucleotide sequence of a human gene for glutathione peroxidase."
Nucleic Acids Res. 15:10051-10051(1987) [PubMed] [Europe PMC] [Abstract]
"Sequence of a cDNA coding for human glutathione peroxidase confirms TGA encodes active site selenocysteine."
Nucleic Acids Res. 15:5484-5484(1987) [PubMed] [Europe PMC] [Abstract]
"Isolation and chromosomal localization of the human glutathione peroxidase gene."
Genomics 6:268-271(1990) [PubMed] [Europe PMC] [Abstract]
"Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1)."
J. Biol. Chem. 267:5949-5958(1992) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1."
Submitted (FEB-2009) to the PDB data bank
"Low yield of polymorphisms from EST blast searching: analysis of genes related to oxidative stress and verification of the P197L polymorphism in GPX1."
Hum. Mutat. 13:294-300(1999) [PubMed] [Europe PMC] [Abstract]
"Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer."
Prostate Cancer Prostatic Dis. 5:189-192(2002) [PubMed] [Europe PMC] [Abstract]
"Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients."
Diabetes 53:2455-2460(2004) [PubMed] [Europe PMC] [Abstract]
"Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant."
J. Urol. 172:728-732(2004) [PubMed] [Europe PMC] [Abstract]