Cathepsin L (CTSL)
CTSL1; CATL; CTS-L; MEP; Cathepsin L1; Major excreted protein
Cathepsin L1, previously called cathepsin L, Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain-like family of cysteine proteinases.
Cathepsin L plays a major role in antigen processing, tumor invasion and metastasis, bone resorption, and turnover of intracellular and secreted proteins involved in growth regulation. Although commonly recognized as a lysosomal protease, cathepsin L is also secreted. This broad-spectrum protease is potent in degrading several extracellular proteins (laminins, fibronectin, collagens I and IV, elastin, and other structural proteins of basement membranes) as well as serum proteins and cytoplasmic and nuclear proteins.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W463Hu01 | Recombinant Cathepsin L (CTSL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cathepsin L (CTSL) | Bioactivity | |
| Antibodies | MW463Hu22 | Monoclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IP. |
| PW463Hu01 | Polyclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IF. | |
| LW463Hu71 | Biotin Linked-Polyclonal Antibody to Cathepsin L (CTSL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW463Hu | ELISA Kit for Cathepsin L (CTSL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cathepsin L (CTSL) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W463Mu01 | Recombinant Cathepsin L (CTSL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cathepsin L (CTSL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IP. |
| PW463Mu01 | Polyclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IF. | |
| LW463Mu71 | Biotin Linked-Polyclonal Antibody to Cathepsin L (CTSL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW463Mu | ELISA Kit for Cathepsin L (CTSL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cathepsin L (CTSL) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W463Ra01 | Recombinant Cathepsin L (CTSL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cathepsin L (CTSL) | Bioactivity | |
| Antibodies | MW463Ra21 | Monoclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IP. |
| PW463Ra01 | Polyclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IF. | |
| LW463Ra71 | Biotin Linked-Polyclonal Antibody to Cathepsin L (CTSL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW463Ra | ELISA Kit for Cathepsin L (CTSL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cathepsin L (CTSL) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cathepsin L (CTSL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cathepsin L (CTSL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cathepsin L (CTSL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cathepsin L (CTSL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cathepsin L (CTSL) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W463Po01 | Recombinant Cathepsin L (CTSL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cathepsin L (CTSL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IP. |
| PW463Po01 | Polyclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IF. | |
| LW463Po71 | Biotin Linked-Polyclonal Antibody to Cathepsin L (CTSL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry | |
| LW463Po81 | FITC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cathepsin L (CTSL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cathepsin L (CTSL) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W463Bo01 | Recombinant Cathepsin L (CTSL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cathepsin L (CTSL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IP. |
| PW463Bo01 | Polyclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cathepsin L (CTSL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cathepsin L (CTSL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cathepsin L (CTSL) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cathepsin L (CTSL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cathepsin L (CTSL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cathepsin L (CTSL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cathepsin L (CTSL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cathepsin L (CTSL) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cathepsin L (CTSL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cathepsin L (CTSL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cathepsin L (CTSL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cathepsin L (CTSL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cathepsin L (CTSL) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cathepsin L (CTSL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cathepsin L (CTSL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cathepsin L (CTSL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cathepsin L (CTSL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cathepsin L (CTSL) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cathepsin L (CTSL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cathepsin L (CTSL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cathepsin L (CTSL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cathepsin L (CTSL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cathepsin L (CTSL) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cathepsin L (CTSL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cathepsin L (CTSL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cathepsin L (CTSL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cathepsin L (CTSL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cathepsin L (CTSL) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cathepsin L (CTSL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cathepsin L (CTSL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cathepsin L (CTSL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cathepsin L (CTSL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cathepsin L (CTSL) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cathepsin L (CTSL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cathepsin L (CTSL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cathepsin L (CTSL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cathepsin L (CTSL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cathepsin L (CTSL) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cathepsin L (CTSL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cathepsin L (CTSL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cathepsin L (CTSL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cathepsin L (CTSL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cathepsin L (CTSL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cathepsin L (CTSL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cathepsin L (CTSL) | CLIA assay for Antigen Detection |
Reference
"Isolation and sequence of a cDNA for human pro-(cathepsin L)."
Biochem. J. 253:303-306(1988) [PubMed] [Europe PMC] [Abstract]
"Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts."
J. Clin. Invest. 81:1621-1629(1988) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Amino acid sequences of the human kidney cathepsins H and L."
FEBS Lett. 228:341-345(1988) [PubMed] [Europe PMC] [Abstract]
"The major ras induced protein in NIH3T3 cells is cathepsin L."
Nucleic Acids Res. 15:3186-3186(1987) [PubMed] [Europe PMC] [Abstract]
"The N-terminal amino acid sequences of the heavy and light chains of human cathepsin L. Relationship to a cDNA clone for a major cysteine proteinase from a mouse macrophage cell line."
Biochem. J. 240:373-377(1986) [PubMed] [Europe PMC] [Abstract]
"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Resveratrol-induced changes of the human adipocyte secretion profile."
J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment."
EMBO J. 15:5492-5503(1996) [PubMed] [Europe PMC] [Abstract]
"The crystal structure of human cathepsin L complexed with E-64."
FEBS Lett. 407:47-50(1997) [PubMed] [Europe PMC] [Abstract]
, Submitted (AUG-1999) to the PDB data bank