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Vasoactive Intestinal Peptide (VIP)

PHM27; Intestinal peptide PHV-42; Peptide histidine valine 42; Peptide histidine methioninamide 27

Vasoactive intestinal peptide (VIP) is a peptide hormone containing 28 amino acid residues and is produced in many areas of the human body including the gut, pancreas and suprachiasmatic nuclei of the hypothalamus in the brain.It has a half-life in the blood of about two minutes. With respect to the digestive system, VIP seems to induce smooth muscle relaxation (lower esophageal sphincter, stomach, gallbladder), stimulate secretion of water into pancreatic juice and bile, and cause inhibition of gastric acid secretion and absorption from the intestinal lumen. Its role in the intestine is to greatly stimulate secretion of water and electrolytes, as well as dilating intestinal smooth muscle, dilating peripheral blood vessels, stimulating pancreatic bicarbonate secretion, and inhibiting gastrin-stimulated gastric acid secretion.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W423Hu01 Recombinant Vasoactive Intestinal Peptide (VIP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vasoactive Intestinal Peptide (VIP) Bioactivity
Antibodies MW423Hu22 Monoclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IP.
PW423Hu01 Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vasoactive Intestinal Peptide (VIP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vasoactive Intestinal Peptide (VIP) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W423Mu01 Recombinant Vasoactive Intestinal Peptide (VIP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vasoactive Intestinal Peptide (VIP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IP.
PW423Mu01 Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vasoactive Intestinal Peptide (VIP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vasoactive Intestinal Peptide (VIP) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W423Ra01 Recombinant Vasoactive Intestinal Peptide (VIP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vasoactive Intestinal Peptide (VIP) Bioactivity
Antibodies MW423Ra21 Monoclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IP.
PW423Ra01 Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vasoactive Intestinal Peptide (VIP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vasoactive Intestinal Peptide (VIP) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vasoactive Intestinal Peptide (VIP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vasoactive Intestinal Peptide (VIP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vasoactive Intestinal Peptide (VIP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vasoactive Intestinal Peptide (VIP) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vasoactive Intestinal Peptide (VIP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vasoactive Intestinal Peptide (VIP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vasoactive Intestinal Peptide (VIP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vasoactive Intestinal Peptide (VIP) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W423Bo01 Recombinant Vasoactive Intestinal Peptide (VIP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vasoactive Intestinal Peptide (VIP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IP.
PW423Bo01 Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vasoactive Intestinal Peptide (VIP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vasoactive Intestinal Peptide (VIP) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vasoactive Intestinal Peptide (VIP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vasoactive Intestinal Peptide (VIP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vasoactive Intestinal Peptide (VIP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vasoactive Intestinal Peptide (VIP) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vasoactive Intestinal Peptide (VIP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vasoactive Intestinal Peptide (VIP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vasoactive Intestinal Peptide (VIP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vasoactive Intestinal Peptide (VIP) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vasoactive Intestinal Peptide (VIP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vasoactive Intestinal Peptide (VIP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vasoactive Intestinal Peptide (VIP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vasoactive Intestinal Peptide (VIP) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vasoactive Intestinal Peptide (VIP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vasoactive Intestinal Peptide (VIP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vasoactive Intestinal Peptide (VIP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vasoactive Intestinal Peptide (VIP) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W423Gu01 Recombinant Vasoactive Intestinal Peptide (VIP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vasoactive Intestinal Peptide (VIP) Bioactivity
Antibodies MW423Gu21 Monoclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IP.
PW423Gu01 Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vasoactive Intestinal Peptide (VIP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vasoactive Intestinal Peptide (VIP) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vasoactive Intestinal Peptide (VIP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vasoactive Intestinal Peptide (VIP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vasoactive Intestinal Peptide (VIP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vasoactive Intestinal Peptide (VIP) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vasoactive Intestinal Peptide (VIP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vasoactive Intestinal Peptide (VIP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vasoactive Intestinal Peptide (VIP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vasoactive Intestinal Peptide (VIP) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Vasoactive Intestinal Peptide (VIP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Vasoactive Intestinal Peptide (VIP) Bioactivity
Antibodies NONE Monoclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Vasoactive Intestinal Peptide (VIP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Vasoactive Intestinal Peptide (VIP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Vasoactive Intestinal Peptide (VIP) CLIA assay for Antigen Detection

Reference

"Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27."
Nature 304:547-549(1983) [PubMed] [Europe PMC] [Abstract]

"Structure of the human vasoactive intestinal polypeptide gene."
DNA 4:293-300(1985) [PubMed] [Europe PMC] [Abstract]

"Vasoactive intestinal peptide: expression of the prohormone in bacterial cells."
Peptides 6 Suppl. 1:95-102(1985) [PubMed] [Europe PMC] [Abstract]

"Structure and expression of the gene encoding the vasoactive intestinal peptide precursor."
Proc. Natl. Acad. Sci. U.S.A. 84:605-609(1987) [PubMed] [Europe PMC] [Abstract]

"Complete nucleotide sequence of human vasoactive intestinal peptide/PHM-27 gene and its inducible promoter."
Ann. N. Y. Acad. Sci. 527:87-102(1988) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structure and expression of the vasoactive intestinal peptide (VIP) gene in a human tumor."
Peptides 7:1-6(1986) [PubMed] [Europe PMC] [Abstract]

"Diarrhoea in vipoma patients associated with cosecretion of a second active peptide (peptide histidine isoleucine) explained by single coding gene."
Lancet 2:1163-1165(1983) [PubMed] [Europe PMC] [Abstract]

"Vasoactive intestinal peptide gene: putative mechanism of information storage at the RNA level."
J. Neurochem. 48:1136-1141(1987) [PubMed] [Europe PMC] [Abstract]

"Isolation, characterization, and pharmacological actions of peptide histidine valine 42, a novel prepro-vasoactive intestinal peptide-derived peptide."
J. Biol. Chem. 262:14010-14013(1987) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma."
Biochem. Biophys. Res. Commun. 185:134-141(1992) [PubMed] [Europe PMC] [Abstract]

"Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor."
Biochem. Pharmacol. 67:1279-1284(2004) [PubMed] [Europe PMC] [Abstract]

"Structural determination of the vasoactive intestinal peptide by two-dimensional H-NMR spectroscopy."
Biopolymers 31:459-464(1991) [PubMed] [Europe PMC] [Abstract]