Complement Component 3a (C3a)

C3a is a one of the proteins formed by the cleavage of complement component 3; the other is C3b.C3a plays an important role in chemotaxis, though not as important a role as C5a.It is also an anaphylatoxin.Soluble C3-convertase, also known as C4b2a, catalyzes the proteolytic cleavage of C3 into C3a and C3b as part of the classical complement system as well as the mannan-binding lectin pathway. C3a is an anaphylotoxin, and C3b serves as an opsonizing agent. Factor I can cleave C3b into C3c and C3d, the latter of which plays a role in enhancing B cell responses. 

Complement Component 3a (C3a) is an essential regulatory factor and inhibiting its binding to a C3a receptor will diminish the inflammation response by disrupting the cascade.