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Tachykinin Receptor 1 (TACR1)

NK1R; SPR; NKIR; TAC1R; Neurokinin 1 Receptor; Substance P Receptor

The tachykinin receptor 1 (TACR1) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene.Fong et al. (1992) cloned a splice variant of human NK1R that encodes a 311-amino acid protein with a truncated C terminus.

This receptor is considered an attractive drug target, particularly with regards to potential analgesics and anti-depressants. It was identified as a candidate in the etiology of bipolar disorder by a 2008 study. Furthermore TACR1 antagonists have shown promise for the treatment in alcoholism. Finally TACR1 antagonists may also have a role as novel antiemetics.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W411Hu01 Recombinant Tachykinin Receptor 1 (TACR1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tachykinin Receptor 1 (TACR1) Bioactivity
Antibodies MW411Hu22 Monoclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
PW411Hu01 Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry;ICC/IF
Assay Kits KEW411Hu ELISA Kit for Tachykinin Receptor 1 (TACR1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tachykinin Receptor 1 (TACR1) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Tachykinin Receptor 1 (TACR1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tachykinin Receptor 1 (TACR1) Bioactivity
Antibodies NONE Monoclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Tachykinin Receptor 1 (TACR1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tachykinin Receptor 1 (TACR1) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Tachykinin Receptor 1 (TACR1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tachykinin Receptor 1 (TACR1) Bioactivity
Antibodies NONE Monoclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Tachykinin Receptor 1 (TACR1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tachykinin Receptor 1 (TACR1) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Tachykinin Receptor 1 (TACR1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tachykinin Receptor 1 (TACR1) Bioactivity
Antibodies NONE Monoclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Tachykinin Receptor 1 (TACR1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tachykinin Receptor 1 (TACR1) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Tachykinin Receptor 1 (TACR1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tachykinin Receptor 1 (TACR1) Bioactivity
Antibodies NONE Monoclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Tachykinin Receptor 1 (TACR1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tachykinin Receptor 1 (TACR1) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Tachykinin Receptor 1 (TACR1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tachykinin Receptor 1 (TACR1) Bioactivity
Antibodies NONE Monoclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Tachykinin Receptor 1 (TACR1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tachykinin Receptor 1 (TACR1) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Tachykinin Receptor 1 (TACR1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tachykinin Receptor 1 (TACR1) Bioactivity
Antibodies NONE Monoclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Tachykinin Receptor 1 (TACR1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tachykinin Receptor 1 (TACR1) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Tachykinin Receptor 1 (TACR1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tachykinin Receptor 1 (TACR1) Bioactivity
Antibodies NONE Monoclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Tachykinin Receptor 1 (TACR1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tachykinin Receptor 1 (TACR1) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Tachykinin Receptor 1 (TACR1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tachykinin Receptor 1 (TACR1) Bioactivity
Antibodies NONE Monoclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Tachykinin Receptor 1 (TACR1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tachykinin Receptor 1 (TACR1) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Tachykinin Receptor 1 (TACR1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tachykinin Receptor 1 (TACR1) Bioactivity
Antibodies NONE Monoclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Tachykinin Receptor 1 (TACR1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tachykinin Receptor 1 (TACR1) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Tachykinin Receptor 1 (TACR1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tachykinin Receptor 1 (TACR1) Bioactivity
Antibodies NONE Monoclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Tachykinin Receptor 1 (TACR1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tachykinin Receptor 1 (TACR1) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Tachykinin Receptor 1 (TACR1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tachykinin Receptor 1 (TACR1) Bioactivity
Antibodies NONE Monoclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Tachykinin Receptor 1 (TACR1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tachykinin Receptor 1 (TACR1) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Tachykinin Receptor 1 (TACR1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tachykinin Receptor 1 (TACR1) Bioactivity
Antibodies NONE Monoclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Tachykinin Receptor 1 (TACR1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tachykinin Receptor 1 (TACR1) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Tachykinin Receptor 1 (TACR1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tachykinin Receptor 1 (TACR1) Bioactivity
Antibodies NONE Monoclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tachykinin Receptor 1 (TACR1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Tachykinin Receptor 1 (TACR1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tachykinin Receptor 1 (TACR1) CLIA assay for Antigen Detection

Reference

"Molecular cloning, structural characterization and functional expression of the human substance P receptor."
Biochem. Biophys. Res. Commun. 179:1232-1240(1991) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterisation of the human lung NK-1 receptor cDNA."
Biochem. Biophys. Res. Commun. 180:1110-1117(1991) [PubMed] [Europe PMC] [Abstract]

"Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones."
Biochemistry 30:10640-10646(1991) [PubMed] [Europe PMC] [Abstract]

"The primary structure and gene organization of human substance P and neuromedin K receptors."
Eur. J. Biochem. 204:1025-1033(1992) [PubMed] [Europe PMC] [Abstract]

"Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor."
Mol. Pharmacol. 41:24-30(1992) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The human tachykinin NK1 (short form) and tachykinin NK4 receptor: a reappraisal."
Eur. J. Pharmacol. 437:27-30(2002) [PubMed] [Europe PMC] [Abstract]

"Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345."
Nature 362:350-353(1993) [PubMed] [Europe PMC] [Abstract]

"NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles."
Biochim. Biophys. Acta 1808:127-139(2011) [PubMed] [Europe PMC] [Abstract]

"Identification of single-nucleotide polymorphisms of the human neurokinin 1 receptor gene and pharmacological characterization of a Y192H variant."
Pharmacogenomics J. 4:394-402(2004) [PubMed] [Europe PMC] [Abstract]