Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2)
PHLD-A2; BRW1C; BWR1C; HLDA2; IPL; TSSC3; Tumor Suppressing Subtransferable Candidate 3; p17-Beckwith-Wiedemann region 1 C; Imprinted in placenta and liver protein
Pleckstrin homology-like domain, family A, member 2, also known as PHLDA2, is one of several genes in the imprinted gene domain of 11p15.5 which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Studies of the mouse gene, however, which is also located in an imprinted gene domain, have shown that the product of this gene regulates placental growth.The IPL gene lies in an extended imprinted region of distal mouse chromosome 7, which also contains the IGF2 gene. Expression of Ipl is highest in placenta and yolk sac, where its mRNA is derived almost entirely from the maternal allele.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW403Hu01 | Recombinant Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW403Hu01 | Monoclonal Antibody to Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | WB; IHC; ICC; IP. |
| PAW403Hu01 | Polyclonal Antibody to Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW403Hu01 | CLIA Kit for Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | CLIA assay for Antigen Detection |
| ELW403Hu01 | ELISA Kit for Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW403Mu01 | Recombinant Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW403Mu01 | Monoclonal Antibody to Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | WB; IHC; ICC; IP. |
| PAW403Mu01 | Polyclonal Antibody to Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW403Mu01 | CLIA Kit for Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | CLIA assay for Antigen Detection |
| ELW403Mu01 | ELISA Kit for Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW403Ra01 | Recombinant Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW403Ra01 | Monoclonal Antibody to Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | WB; IHC; ICC; IP. |
| PAW403Ra01 | Polyclonal Antibody to Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW403Ra01 | CLIA Kit for Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | CLIA assay for Antigen Detection |
| ELW403Ra01 | ELISA Kit for Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW403Ca01 | Recombinant Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW403Ca01 | Monoclonal Antibody to Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | WB; IHC; ICC; IP. |
| PAW403Ca01 | Polyclonal Antibody to Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW403Ca01 | CLIA Kit for Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | CLIA assay for Antigen Detection |
| ELW403Ca01 | ELISA Kit for Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW403Po01 | Recombinant Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW403Po01 | Monoclonal Antibody to Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | WB; IHC; ICC; IP. |
| PAW403Po01 | Polyclonal Antibody to Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW403Po01 | CLIA Kit for Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | CLIA assay for Antigen Detection |
| ELW403Po01 | ELISA Kit for Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW403Bo01 | Recombinant Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW403Bo01 | Monoclonal Antibody to Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | WB; IHC; ICC; IP. |
| PAW403Bo01 | Polyclonal Antibody to Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW403Bo01 | CLIA Kit for Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | CLIA assay for Antigen Detection |
| ELW403Bo01 | ELISA Kit for Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW403Rb01 | Recombinant Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW403Rb01 | Monoclonal Antibody to Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | WB; IHC; ICC; IP. |
| PAW403Rb01 | Polyclonal Antibody to Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW403Rb01 | CLIA Kit for Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | CLIA assay for Antigen Detection |
| ELW403Rb01 | ELISA Kit for Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW403Mo01 | Recombinant Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW403Mo01 | Monoclonal Antibody to Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | WB; IHC; ICC; IP. |
| PAW403Mo01 | Polyclonal Antibody to Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW403Mo01 | CLIA Kit for Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | CLIA assay for Antigen Detection |
| ELW403Mo01 | ELISA Kit for Pleckstrin Homology Like Domain Family A, Member 2 (PHLDA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes."
Genomics 46:9-17(1997) [PubMed] [Europe PMC] [Abstract]
"The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis."
Hum. Mol. Genet. 6:2021-2029(1997) [PubMed] [Europe PMC] [Abstract]
"Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples."
Proc. Natl. Acad. Sci. U.S.A. 95:3873-3878(1998) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting."
Mamm. Genome 10:1150-1159(1999) [PubMed] [Europe PMC] [Abstract]
"Retention of imprinting of the human apoptosis-related gene TSSC3 in human brain tumors."
Hum. Mol. Genet. 9:757-763(2000) [PubMed] [Europe PMC] [Abstract]
"The product of the imprinted gene IPL marks human villous cytotrophoblast and is lost in complete hydatidiform mole."
Placenta 24:835-842(2003) [PubMed] [Europe PMC] [Abstract]
"Immunohistochemistry for the imprinted gene product IPL/PHLDA2 for facilitating the differential diagnosis of complete hydatidiform mole."
J. Reprod. Med. 49:630-636(2004) [PubMed] [Europe PMC] [Abstract]
"Complete hydatidiform mole retaining a chromosome 11 of maternal origin: molecular genetic analysis of a case."
Mod. Pathol. 17:1155-1160(2004) [PubMed] [Europe PMC] [Abstract]
"Upregulation of PHLDA2 in Dicer knockdown HEK293 cells."
Biochim. Biophys. Acta 1770:820-825(2007) [PubMed] [Europe PMC] [Abstract]
"Hypoxia regulates the expression of PHLDA2 in primary term human trophoblasts."
Placenta 28:77-84(2007) [PubMed] [Europe PMC] [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt."
Cell 136:535-550(2009) [PubMed] [Europe PMC] [Abstract]
"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]