GATA Binding Protein 3 (GATA3)

HDR; Trans-acting T-cell-specific transcription factor GATA-3

SPN	W395
HGNC	4172
MGI	95663
PubMed	19151747
RGD	621250
UniProt	P23771
Wiki	GATA3

Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells, macrophages, or HeLa cell lines. GATA3 was abundantly expressed in the T-lymphocyte lineage and was thought to participate in T-cell receptor gene activation through binding to enhancers. Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The 2 zinc fingers of GATA3 are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.

Reference

"A T-cell specific TCR delta DNA binding protein is a member of the human GATA family."
EMBO J. 10:1809-1816(1991) [PubMed] [Europe PMC] [Abstract]

"Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene."
EMBO J. 10:1187-1192(1991) [PubMed] [Europe PMC] [Abstract]

"Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer."
Mol. Cell. Biol. 11:2778-2784(1991) [PubMed] [Europe PMC] [Abstract]

"The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements."
Proc. Natl. Acad. Sci. U.S.A. 88:7284-7288(1991) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"GATA3 haplo-insufficiency causes human HDR syndrome."
Nature 406:419-422(2000) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Genome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity."
PLoS ONE 8:E66468-E66468(2013) [PubMed] [Europe PMC] [Abstract]

"DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation."
Cell Rep. 2:1197-1206(2012) [PubMed] [Europe PMC] [Abstract]

"GATA3 abnormalities and the phenotypic spectrum of HDR syndrome."
J. Med. Genet. 38:374-380(2001) [PubMed] [Europe PMC] [Abstract]

"Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."
Breast Cancer Res. 9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]