Phospholipase A2, Calcium Independent (iPLA2)

PLA2G6; CaI-PLA2; GVI; INAD1; PNPLA9; Ca2+ Independent PLA2; 85 kDa Calcium-Independent Phospholipase A2; Phospholipase A2,group VI(Cytosolic,Calcium-Independent)

SPN	W394
HGNC	9039
MGI	1859152
PubMed	18936091
RGD	628867
UniProt	O60733
Wiki	PLA2G6

85 kDa calcium-independent phospholipase A2 is is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only two of them have been determined to date.Tang et al. (1997) purified an 85-kD cytosolic calcium-independent PLA2, termed iPLA2, from Chinese hamster ovary (CHO) cells. They isolated a partial human cDNA from a Burkitt lymphoma cDNA library by screening with a CHO cDNA. Northern blot analysis revealed that iPLA2 is expressed in a variety of rodent tissues.

Reference

"Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity."
J. Biol. Chem. 273:207-214(1998) [PubMed] [Europe PMC] [Abstract]

"Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1."
J. Biol. Chem. 274:9607-9616(1999) [PubMed] [Europe PMC] [Abstract]

"The human calcium-independent phospholipase A2 gene. Multiple enzymes with distinct properties from a single gene."
Eur. J. Biochem. 262:575-585(1999) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"iPLA2beta: front and center in human monocyte chemotaxis to MCP-1."
J. Exp. Med. 205:347-359(2008) [PubMed] [Europe PMC] [Abstract]

"Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions."
J. Lipid Res. 50:S63-S68(2009) [PubMed] [Europe PMC] [Abstract]

"Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome."
Proc. Natl. Acad. Sci. U.S.A. 106:2337-2341(2009) [PubMed] [Europe PMC] [Abstract]

"PLA2G6 mutation underlies infantile neuroaxonal dystrophy."
Am. J. Hum. Genet. 79:942-948(2006) [PubMed] [Europe PMC] [Abstract]

"PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron."
Nat. Genet. 38:752-754(2006) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 38:957-957(2006)

"Characterization of PLA2G6 as a locus for dystonia-parkinsonism."
Ann. Neurol. 65:19-23(2009) [PubMed] [Europe PMC] [Abstract]

"Recessive truncating NALCN mutation in infantile neuroaxonal dystrophy with facial dysmorphism."
J. Med. Genet. 50:515-520(2013) [PubMed] [Europe PMC] [Abstract]