Mucin 1 (MUC1)
CD227; EMA; H23AG; KL-6; PEM; PEMT; PUM; CA15-3; Cancer antigen 15-3; Carcinoma-associated mucin; Episialin; Peanut-reactive urinary mucin; Polymorphic epithelial mucin
MUC1 is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 amino acid variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals.
The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW392Hu01 | Recombinant Mucin 1 (MUC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW392Hu01 | Monoclonal Antibody to Mucin 1 (MUC1) | WB; IHC; ICC; IP. |
| PAW392Hu01 | Polyclonal Antibody to Mucin 1 (MUC1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW392Hu01 | CLIA Kit for Mucin 1 (MUC1) | CLIA assay for Antigen Detection |
| ELW392Hu01 | ELISA Kit for Mucin 1 (MUC1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW392Mu01 | Recombinant Mucin 1 (MUC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW392Mu01 | Monoclonal Antibody to Mucin 1 (MUC1) | WB; IHC; ICC; IP. |
| PAW392Mu01 | Polyclonal Antibody to Mucin 1 (MUC1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW392Mu01 | CLIA Kit for Mucin 1 (MUC1) | CLIA assay for Antigen Detection |
| ELW392Mu01 | ELISA Kit for Mucin 1 (MUC1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW392Ra01 | Recombinant Mucin 1 (MUC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW392Ra01 | Monoclonal Antibody to Mucin 1 (MUC1) | WB; IHC; ICC; IP. |
| PAW392Ra01 | Polyclonal Antibody to Mucin 1 (MUC1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW392Ra01 | CLIA Kit for Mucin 1 (MUC1) | CLIA assay for Antigen Detection |
| ELW392Ra01 | ELISA Kit for Mucin 1 (MUC1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW392Ca01 | Recombinant Mucin 1 (MUC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW392Ca01 | Monoclonal Antibody to Mucin 1 (MUC1) | WB; IHC; ICC; IP. |
| PAW392Ca01 | Polyclonal Antibody to Mucin 1 (MUC1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW392Ca01 | CLIA Kit for Mucin 1 (MUC1) | CLIA assay for Antigen Detection |
| ELW392Ca01 | ELISA Kit for Mucin 1 (MUC1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW392Po01 | Recombinant Mucin 1 (MUC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW392Po01 | Monoclonal Antibody to Mucin 1 (MUC1) | WB; IHC; ICC; IP. |
| PAW392Po01 | Polyclonal Antibody to Mucin 1 (MUC1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW392Po01 | CLIA Kit for Mucin 1 (MUC1) | CLIA assay for Antigen Detection |
| ELW392Po01 | ELISA Kit for Mucin 1 (MUC1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW392Bo01 | Recombinant Mucin 1 (MUC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW392Bo01 | Monoclonal Antibody to Mucin 1 (MUC1) | WB; IHC; ICC; IP. |
| PAW392Bo01 | Polyclonal Antibody to Mucin 1 (MUC1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW392Bo01 | CLIA Kit for Mucin 1 (MUC1) | CLIA assay for Antigen Detection |
| ELW392Bo01 | ELISA Kit for Mucin 1 (MUC1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW392Rb01 | Recombinant Mucin 1 (MUC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW392Rb01 | Monoclonal Antibody to Mucin 1 (MUC1) | WB; IHC; ICC; IP. |
| PAW392Rb01 | Polyclonal Antibody to Mucin 1 (MUC1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW392Rb01 | CLIA Kit for Mucin 1 (MUC1) | CLIA assay for Antigen Detection |
| ELW392Rb01 | ELISA Kit for Mucin 1 (MUC1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW392Mo01 | Recombinant Mucin 1 (MUC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW392Mo01 | Monoclonal Antibody to Mucin 1 (MUC1) | WB; IHC; ICC; IP. |
| PAW392Mo01 | Polyclonal Antibody to Mucin 1 (MUC1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW392Mo01 | CLIA Kit for Mucin 1 (MUC1) | CLIA assay for Antigen Detection |
| ELW392Mo01 | ELISA Kit for Mucin 1 (MUC1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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"Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin."
J. Biol. Chem. 265:15286-15293(1990) [PubMed] [Europe PMC] [Abstract]
"Structure and expression of the human polymorphic epithelial mucin gene: an expressed VNTR unit."
Biochem. Biophys. Res. Commun. 173:1019-1029(1990) [PubMed] [Europe PMC] [Abstract]
"Human epithelial tumor antigen cDNA sequences. Differential splicing may generate multiple protein forms."
Eur. J. Biochem. 189:463-473(1990) [PubMed] [Europe PMC] [Abstract]
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Eur. J. Biochem. 189:475-486(1990) [PubMed] [Europe PMC] [Abstract]
"Isolation and characterization of an expressed hypervariable gene coding for a breast-cancer-associated antigen."
Gene 93:313-318(1990) [PubMed] [Europe PMC] [Abstract]
"Characterization and molecular cloning of a novel MUC1 protein, devoid of tandem repeats, expressed in human breast cancer tissue."
Eur. J. Biochem. 224:787-795(1994) [PubMed] [Europe PMC] [Abstract]
"Comparison of MUC-1 mucin expression in epithelial and non-epithelial cancer cell lines and demonstration of a new short variant form (MUC-1/Z)."
Int. J. Cancer 72:87-94(1997) [PubMed] [Europe PMC] [Abstract]
"A novel protein derived from the MUC1 gene by alternative splicing and frameshifting."
J. Biol. Chem. 280:10655-10663(2005) [PubMed] [Europe PMC] [Abstract]
"Human mucin MUC1 RNA undergoes different types of alternative splicing resulting in multiple isoforms."
Cancer Immunol. Immunother. 62:423-435(2013) [PubMed] [Europe PMC] [Abstract]
"Soluble expression of peptide containing MUC1/Y-specific epitope in Escherichia coli and preparation of the antibody."
Sheng Wu Gong Cheng Xue Bao 19:337-342(2003) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats."
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"Sequence analysis of the 5' region of the human DF3 breast carcinoma-associated antigen gene."
Biochem. Biophys. Res. Commun. 165:644-649(1989) [PubMed] [Europe PMC] [Abstract]
"Preoperative diagnosis of thyroid papillary carcinoma by reverse transcriptase polymerase chain reaction of the MUC1 gene."
Int. J. Cancer 66:55-59(1996) [PubMed] [Europe PMC] [Abstract]
"Mucin mRNA expression in lung adenocarcinoma cell lines and tissues."
Oncology 53:118-126(1996) [PubMed] [Europe PMC] [Abstract]
"Identification of MUC1 proteolytic cleavage sites in vivo."
Biochem. Biophys. Res. Commun. 283:715-720(2001) [PubMed] [Europe PMC] [Abstract]
"The MUC1 SEA module is a self-cleaving domain."
J. Biol. Chem. 280:33374-33386(2005) [PubMed] [Europe PMC] [Abstract]
"High density O-glycosylation on tandem repeat peptide from secretory MUC1 of T47D breast cancer cells."
J. Biol. Chem. 274:18165-18172(1999) [PubMed] [Europe PMC] [Abstract]
"Tyrosine phosphorylation of the MUC1 breast cancer membrane proteins. Cytokine receptor-like molecules."
FEBS Lett. 356:130-136(1994) [PubMed] [Europe PMC] [Abstract]
"Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein."
Cancer Res. 55:4000-4003(1995) [PubMed] [Europe PMC] [Abstract]
"Studies on the order and site specificity of GalNAc transfer to MUC1 tandem repeats by UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase from milk or mammary carcinoma cells."
Eur. J. Biochem. 229:140-147(1995) [PubMed] [Europe PMC] [Abstract]
"Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion."
J. Biol. Chem. 272:12492-12494(1997) [PubMed] [Europe PMC] [Abstract]
"Localization of O-glycosylation sites on glycopeptide fragments from lactation-associated MUC1. All putative sites within the tandem repeat are glycosylation targets in vivo."
J. Biol. Chem. 272:24780-24793(1997) [PubMed] [Europe PMC] [Abstract]
"Developmental expression of mucin genes in the human gastrointestinal system."
Gut 42:220-226(1998) [PubMed] [Europe PMC] [Abstract]
"Localization of O-glycosylation sites of MUC1 tandem repeats by QTOF ESI mass spectrometry."
J. Mass Spectrom. 33:358-362(1998) [PubMed] [Europe PMC] [Abstract]
"Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin."
Mol. Cell. Biol. 18:7216-7224(1998) [PubMed] [Europe PMC] [Abstract]
"The breast cancer-associated MUC1 gene generates both a receptor and its cognate binding protein."
Cancer Res. 59:1552-1561(1999) [PubMed] [Europe PMC] [Abstract]
"MUC1 mucin core protein binds to the domain 1 of ICAM-1."
Digestion 63 Suppl. 1:87-92(2001) [PubMed] [Europe PMC] [Abstract]
"Mucin MUC1 is seen in cell surface protrusions together with ezrin in immunoelectron tomography and is concentrated at tips of filopodial protrusions in MCF-7 breast carcinoma cells."
J. Histochem. Cytochem. 49:67-77(2001) [PubMed] [Europe PMC] [Abstract]
"The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin."
J. Biol. Chem. 276:6061-6064(2001) [PubMed] [Europe PMC] [Abstract]
"Identification and topology of variant sequences within individual repeat domains of the human epithelial tumor mucin MUC1."
J. Biol. Chem. 276:27764-27769(2001) [PubMed] [Europe PMC] [Abstract]
"The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin."
J. Biol. Chem. 276:35239-35242(2001) [PubMed] [Europe PMC] [Abstract]
"Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling."
J. Biol. Chem. 277:17616-17622(2002) [PubMed] [Europe PMC] [Abstract]
"Identification of four sites of stimulated tyrosine phosphorylation in the MUC1 cytoplasmic tail."
Biochem. Biophys. Res. Commun. 310:341-346(2003) [PubMed] [Europe PMC] [Abstract]
"DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7."
Cancer Biol. Ther. 2:187-193(2003) [PubMed] [Europe PMC] [Abstract]
"MUC1 cytoplasmic domain coactivates Wnt target gene transcription and confers transformation."
Cancer Biol. Ther. 2:702-706(2003) [PubMed] [Europe PMC] [Abstract]
"Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding."
J. Biol. Chem. 278:3386-3394(2003) [PubMed] [Europe PMC] [Abstract]
"Nuclear association of the cytoplasmic tail of MUC1 and beta-catenin."
J. Biol. Chem. 278:38029-38039(2003) [PubMed] [Europe PMC] [Abstract]
"Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein."
Mol. Cancer Res. 1:765-775(2003) [PubMed] [Europe PMC] [Abstract]
"MUC1 membrane trafficking is modulated by multiple interactions."
J. Biol. Chem. 279:53071-53077(2004) [PubMed] [Europe PMC] [Abstract]
"Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response."
Cancer Cell 7:167-178(2005) [PubMed] [Europe PMC] [Abstract]
"MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of beta-catenin."
Cancer Res. 65:10413-10422(2005) [PubMed] [Europe PMC] [Abstract]
Erratum
J. Biol. Chem. 280:28827-28827(2005)
"Transmembrane and secreted MUC1 probes show trafficking-dependent changes in O-glycan core profiles."
Glycobiology 15:1111-1124(2005) [PubMed] [Europe PMC] [Abstract]
"MUC1 (CD227) interacts with lck tyrosine kinase in Jurkat lymphoma cells and normal T cells."
J. Leukoc. Biol. 77:90-99(2005) [PubMed] [Europe PMC] [Abstract]
"Recycling of MUC1 is dependent on its palmitoylation."
J. Biol. Chem. 281:12112-12122(2006) [PubMed] [Europe PMC] [Abstract]
"MUC1 oncoprotein stabilizes and activates estrogen receptor alpha."
Mol. Cell 21:295-305(2006) [PubMed] [Europe PMC] [Abstract]
"MUC1 inhibits cell proliferation by a beta-catenin-dependent mechanism."
Biochim. Biophys. Acta 1773:1028-1038(2007) [PubMed] [Europe PMC] [Abstract]
"Human mucin 1 oncoprotein represses transcription of the p53 tumor suppressor gene."
Cancer Res. 67:1853-1858(2007) [PubMed] [Europe PMC] [Abstract]
"Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells."
Cancer Res. 67:5201-5210(2007) [PubMed] [Europe PMC] [Abstract]
"MUC1 is a novel regulator of ErbB1 receptor trafficking."
Oncogene 26:1693-1701(2007) [PubMed] [Europe PMC] [Abstract]
"CA 15-3: uses and limitation as a biomarker for breast cancer."
Clin. Chim. Acta 411:1869-1874(2010) [PubMed] [Europe PMC] [Abstract]
"Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing."
Nat. Genet. 45:299-303(2013) [PubMed] [Europe PMC] [Abstract]
"N-glycosylation of the MUC1 mucin in epithelial cells and secretions."
Glycobiology 16:623-634(2006) [PubMed] [Europe PMC] [Abstract]