Protein Kinase C Gamma (PKCg)

PKC-G; PRKCG; PKCC; SCA14; PKC-Gamma

SPN	W386
HGNC	9402
MGI	97597
PubMed	2460293
RGD	3397
UniProt	P05129
Wiki	PRKCG

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase.

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways."
Science 233:859-866(1986) [PubMed] [Europe PMC] [Abstract]

"Activation and substrate specificity of the human protein kinase C alpha and zeta isoenzymes."
Eur. J. Biochem. 216:597-606(1993) [PubMed] [Europe PMC] [Abstract]

"The C2 domain of PKCdelta is a phosphotyrosine binding domain."
Cell 121:271-280(2005) [PubMed] [Europe PMC] [Abstract]

"Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage."
J. Biol. Chem. 281:5734-5740(2006) [PubMed] [Europe PMC] [Abstract]

"Protein kinase C gamma (PKC gamma): function of neuron specific isotype."
J. Biochem. 132:683-687(2002) [PubMed] [Europe PMC] [Abstract]

"Protein kinase C as a stress sensor."
Cell. Signal. 19:1820-1829(2007) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Development and validation of a method for profiling post-translational modification activities using protein microarrays."
PLoS ONE 5:E11332-E11332(2010) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the phorbol esters/diacylglycerol binding domain of protein kinase C gamma."
Submitted (DEC-2007) to the PDB data bank

"Crystal structure of C2 domain of protein kinase C gamma."
Submitted (APR-2007) to the PDB data bank

"Segregation of a PRKCG mutation in two RP11 families."
Am. J. Hum. Genet. 62:1248-1252(1998) [PubMed] [Europe PMC] [Abstract]

"No mutations in the coding region of the PRKCG gene in three families with retinitis pigmentosa linked to the RP11 locus on chromosome 19q."
Am. J. Hum. Genet. 65:926-928(1999) [PubMed] [Europe PMC] [Abstract]

"Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxia."
Am. J. Hum. Genet. 72:839-849(2003) [PubMed] [Europe PMC] [Abstract]