Synaptophysin (SYP)
Major synaptic vesicle protein p38
Synaptophysin is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. It acts as a marker for neuroendocrine tumors, and its ubiquity at the synapse has lead to the use of synaptophysin immunostaining for quantification of synapses.
The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally.Synaptophysin can refer both to the vesicle membrane protein.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW380Hu01 | Recombinant Synaptophysin (SYP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW380Hu01 | Monoclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IP. |
| PAW380Hu01 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW380Hu01 | CLIA Kit for Synaptophysin (SYP) | CLIA assay for Antigen Detection |
| ELW380Hu01 | ELISA Kit for Synaptophysin (SYP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW380Mu01 | Recombinant Synaptophysin (SYP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW380Mu01 | Monoclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IP. |
| PAW380Mu01 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW380Mu01 | CLIA Kit for Synaptophysin (SYP) | CLIA assay for Antigen Detection |
| ELW380Mu01 | ELISA Kit for Synaptophysin (SYP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW380Ra01 | Recombinant Synaptophysin (SYP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW380Ra01 | Monoclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IP. |
| PAW380Ra01 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW380Ra01 | CLIA Kit for Synaptophysin (SYP) | CLIA assay for Antigen Detection |
| ELW380Ra01 | ELISA Kit for Synaptophysin (SYP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW380Ca01 | Recombinant Synaptophysin (SYP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW380Ca01 | Monoclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IP. |
| PAW380Ca01 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW380Ca01 | CLIA Kit for Synaptophysin (SYP) | CLIA assay for Antigen Detection |
| ELW380Ca01 | ELISA Kit for Synaptophysin (SYP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW380Po01 | Recombinant Synaptophysin (SYP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW380Po01 | Monoclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IP. |
| PAW380Po01 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW380Po01 | CLIA Kit for Synaptophysin (SYP) | CLIA assay for Antigen Detection |
| ELW380Po01 | ELISA Kit for Synaptophysin (SYP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW380Bo01 | Recombinant Synaptophysin (SYP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW380Bo01 | Monoclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IP. |
| PAW380Bo01 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW380Bo01 | CLIA Kit for Synaptophysin (SYP) | CLIA assay for Antigen Detection |
| ELW380Bo01 | ELISA Kit for Synaptophysin (SYP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW380Rb01 | Recombinant Synaptophysin (SYP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW380Rb01 | Monoclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IP. |
| PAW380Rb01 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW380Rb01 | CLIA Kit for Synaptophysin (SYP) | CLIA assay for Antigen Detection |
| ELW380Rb01 | ELISA Kit for Synaptophysin (SYP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW380Mo01 | Recombinant Synaptophysin (SYP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW380Mo01 | Monoclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IP. |
| PAW380Mo01 | Polyclonal Antibody to Synaptophysin (SYP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW380Mo01 | CLIA Kit for Synaptophysin (SYP) | CLIA assay for Antigen Detection |
| ELW380Mo01 | ELISA Kit for Synaptophysin (SYP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The cDNA and derived amino acid sequences for rat and human synaptophysin."
Nucleic Acids Res. 15:9607-9607(1987) [PubMed] [Europe PMC] [Abstract]
"Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse."
Am. J. Hum. Genet. 47:551-561(1990) [PubMed] [Europe PMC] [Abstract]
"Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp."
Genomics 45:340-347(1997) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex."
J. Neurochem. 107:61-72(2008) [PubMed] [Europe PMC] [Abstract]
"A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation."
Nat. Genet. 41:535-543(2009) [PubMed] [Europe PMC] [Abstract]