Apoptosis Associated Tyrosine Kinase (AATK)
AATYK; LMR1; p35BP; Serine/Threonine-Protein Kinase LMTK1; Lemur Tyrosine Kinase 1; Brain apoptosis-associated tyrosine kinase; CDK5-binding protein; p35-binding protein
AATK is a novel gene which is induced during apoptosis. It encodes a protein with a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. AATK expression may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells.By randomly selecting cDNA clones from size-fractionated human brain cDNA libraries, Ishikawa et al. (1998) identified a full-length cDNA clone, which they called KIAA0641, encoding a protein with significant homology to the mouse Aatyk protein identified by Gaozza et al. (1997). The deduced human AATK protein contains 1,207 amino acids and has an observed molecular mass greater than 100 kD. By RT-PCR, Ishikawa et al. (1998) detected expression of AATK in brain, lung, kidney, and pancreas.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW376Hu01 | Recombinant Apoptosis Associated Tyrosine Kinase (AATK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW376Hu01 | Monoclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK) | WB; IHC; ICC; IP. |
| PAW376Hu01 | Polyclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW376Hu01 | CLIA Kit for Apoptosis Associated Tyrosine Kinase (AATK) | CLIA assay for Antigen Detection |
| ELW376Hu01 | ELISA Kit for Apoptosis Associated Tyrosine Kinase (AATK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW376Mu01 | Recombinant Apoptosis Associated Tyrosine Kinase (AATK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW376Mu01 | Monoclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK) | WB; IHC; ICC; IP. |
| PAW376Mu01 | Polyclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW376Mu01 | CLIA Kit for Apoptosis Associated Tyrosine Kinase (AATK) | CLIA assay for Antigen Detection |
| ELW376Mu01 | ELISA Kit for Apoptosis Associated Tyrosine Kinase (AATK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW376Ra01 | Recombinant Apoptosis Associated Tyrosine Kinase (AATK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW376Ra01 | Monoclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK) | WB; IHC; ICC; IP. |
| PAW376Ra01 | Polyclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW376Ra01 | CLIA Kit for Apoptosis Associated Tyrosine Kinase (AATK) | CLIA assay for Antigen Detection |
| ELW376Ra01 | ELISA Kit for Apoptosis Associated Tyrosine Kinase (AATK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW376Ca01 | Recombinant Apoptosis Associated Tyrosine Kinase (AATK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW376Ca01 | Monoclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK) | WB; IHC; ICC; IP. |
| PAW376Ca01 | Polyclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW376Ca01 | CLIA Kit for Apoptosis Associated Tyrosine Kinase (AATK) | CLIA assay for Antigen Detection |
| ELW376Ca01 | ELISA Kit for Apoptosis Associated Tyrosine Kinase (AATK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW376Po01 | Recombinant Apoptosis Associated Tyrosine Kinase (AATK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW376Po01 | Monoclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK) | WB; IHC; ICC; IP. |
| PAW376Po01 | Polyclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW376Po01 | CLIA Kit for Apoptosis Associated Tyrosine Kinase (AATK) | CLIA assay for Antigen Detection |
| ELW376Po01 | ELISA Kit for Apoptosis Associated Tyrosine Kinase (AATK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW376Bo01 | Recombinant Apoptosis Associated Tyrosine Kinase (AATK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW376Bo01 | Monoclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK) | WB; IHC; ICC; IP. |
| PAW376Bo01 | Polyclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW376Bo01 | CLIA Kit for Apoptosis Associated Tyrosine Kinase (AATK) | CLIA assay for Antigen Detection |
| ELW376Bo01 | ELISA Kit for Apoptosis Associated Tyrosine Kinase (AATK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW376Rb01 | Recombinant Apoptosis Associated Tyrosine Kinase (AATK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW376Rb01 | Monoclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK) | WB; IHC; ICC; IP. |
| PAW376Rb01 | Polyclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW376Rb01 | CLIA Kit for Apoptosis Associated Tyrosine Kinase (AATK) | CLIA assay for Antigen Detection |
| ELW376Rb01 | ELISA Kit for Apoptosis Associated Tyrosine Kinase (AATK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW376Mo01 | Recombinant Apoptosis Associated Tyrosine Kinase (AATK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW376Mo01 | Monoclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK) | WB; IHC; ICC; IP. |
| PAW376Mo01 | Polyclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW376Mo01 | CLIA Kit for Apoptosis Associated Tyrosine Kinase (AATK) | CLIA assay for Antigen Detection |
| ELW376Mo01 | ELISA Kit for Apoptosis Associated Tyrosine Kinase (AATK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein."
Biochem. Biophys. Res. Commun. 310:398-404(2003) [PubMed] [Europe PMC] [Abstract]
"A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line."
Brain Res. Mol. Brain Res. 77:151-162(2000) [PubMed] [Europe PMC] [Abstract]
"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]