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Granzyme M (GZMM)

GZM-M; LMET1; MET1; Hu-Met-1; Met-ase; Lymphocyte Met Ase 1; Met-1 serine protease; Natural killer cell granular protease

SPN W374
HGNC 4712
MGI 99549
PubMed 16818775
RGD 620022
UniProt P51124
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M.
By fluorescence in situ hybridization, Pilat et al. (1994) mapped the GZMM gene to chromosome 19p13.3. Interphase studies with 2 differentially labeled probes for GZMM and the azurocidin (AZU1), proteinase-3 (PRTN3), and elastase-2 (ELA2) gene cluster indicated that the GZMM gene is 200 to 500 kb from that gene cluster.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W374Hu01 Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Granzyme M (GZMM) Bioactivity
Antibodies MW374Hu22 Monoclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
PW374Hu01 Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IF.
LW374Hu71 Biotin Linked-Polyclonal Antibody to Granzyme M (GZMM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Granzyme M (GZMM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Granzyme M (GZMM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry
LW374Hu81 FITC Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry;ICC/IF
Assay Kits KEW374Hu ELISA Kit for Granzyme M (GZMM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Granzyme M (GZMM) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W374Mu01 Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Granzyme M (GZMM) Bioactivity
Antibodies NONE Monoclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
PW374Mu01 Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Granzyme M (GZMM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Granzyme M (GZMM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Granzyme M (GZMM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry;ICC/IF
Assay Kits KEW374Mu ELISA Kit for Granzyme M (GZMM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Granzyme M (GZMM) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W374Ra01 Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Granzyme M (GZMM) Bioactivity
Antibodies NONE Monoclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
PW374Ra01 Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Granzyme M (GZMM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Granzyme M (GZMM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Granzyme M (GZMM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Granzyme M (GZMM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Granzyme M (GZMM) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Granzyme M (GZMM) Bioactivity
Antibodies NONE Monoclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Granzyme M (GZMM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Granzyme M (GZMM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Granzyme M (GZMM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Granzyme M (GZMM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Granzyme M (GZMM) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W374Po01 Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Granzyme M (GZMM) Bioactivity
Antibodies NONE Monoclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
PW374Po01 Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Granzyme M (GZMM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Granzyme M (GZMM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Granzyme M (GZMM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Granzyme M (GZMM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Granzyme M (GZMM) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Granzyme M (GZMM) Bioactivity
Antibodies NONE Monoclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Granzyme M (GZMM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Granzyme M (GZMM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Granzyme M (GZMM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Granzyme M (GZMM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Granzyme M (GZMM) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Granzyme M (GZMM) Bioactivity
Antibodies NONE Monoclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Granzyme M (GZMM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Granzyme M (GZMM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Granzyme M (GZMM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Granzyme M (GZMM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Granzyme M (GZMM) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Granzyme M (GZMM) Bioactivity
Antibodies NONE Monoclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Granzyme M (GZMM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Granzyme M (GZMM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Granzyme M (GZMM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Granzyme M (GZMM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Granzyme M (GZMM) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Granzyme M (GZMM) Bioactivity
Antibodies NONE Monoclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Granzyme M (GZMM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Granzyme M (GZMM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Granzyme M (GZMM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Granzyme M (GZMM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Granzyme M (GZMM) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Granzyme M (GZMM) Bioactivity
Antibodies NONE Monoclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Granzyme M (GZMM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Granzyme M (GZMM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Granzyme M (GZMM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Granzyme M (GZMM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Granzyme M (GZMM) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Granzyme M (GZMM) Bioactivity
Antibodies NONE Monoclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Granzyme M (GZMM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Granzyme M (GZMM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Granzyme M (GZMM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Granzyme M (GZMM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Granzyme M (GZMM) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Granzyme M (GZMM) Bioactivity
Antibodies NONE Monoclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Granzyme M (GZMM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Granzyme M (GZMM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Granzyme M (GZMM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Granzyme M (GZMM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Granzyme M (GZMM) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Granzyme M (GZMM) Bioactivity
Antibodies NONE Monoclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Granzyme M (GZMM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Granzyme M (GZMM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Granzyme M (GZMM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Granzyme M (GZMM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Granzyme M (GZMM) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Granzyme M (GZMM) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Granzyme M (GZMM) Bioactivity
Antibodies NONE Monoclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Granzyme M (GZMM) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Granzyme M (GZMM) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Granzyme M (GZMM) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Granzyme M (GZMM) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Granzyme M (GZMM) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Granzyme M (GZMM) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Granzyme M (GZMM) CLIA assay for Antigen Detection

Reference

"Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells."
J. Immunol. 151:6195-6205(1993) [PubMed] [Europe PMC] [Abstract]

"The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3."
Genomics 24:445-450(1994) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network."
J. Immunol. 180:8184-8191(2008) [PubMed] [Europe PMC] [Abstract]

"Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells."
J. Biol. Chem. 285:18326-18335(2010) [PubMed] [Europe PMC] [Abstract]

"Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M."
J. Immunol. 183:421-429(2009) [PubMed] [Europe PMC] [Abstract]

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