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Estrogen Receptor Beta (ERb)

ER-B; ESRB; ESTRB; NR3A2; NR3-A2; ESR2; Estrogen Receptor 2; Nuclear Receptor Subfamily 3,Group A,Member 2

Estrogen receptor beta is a nuclear receptor which is activated by the sex hormone estrogen. a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW369Hu01 Recombinant Estrogen Receptor Beta (ERb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW369Hu01 Monoclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IP.
PAW369Hu01 Polyclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IF.
Assay Kits CLW369Hu01 CLIA Kit for Estrogen Receptor Beta (ERb) CLIA assay for Antigen Detection
ELW369Hu01 ELISA Kit for Estrogen Receptor Beta (ERb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW369Mu01 Recombinant Estrogen Receptor Beta (ERb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW369Mu01 Monoclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IP.
PAW369Mu01 Polyclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IF.
Assay Kits CLW369Mu01 CLIA Kit for Estrogen Receptor Beta (ERb) CLIA assay for Antigen Detection
ELW369Mu01 ELISA Kit for Estrogen Receptor Beta (ERb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW369Ra01 Recombinant Estrogen Receptor Beta (ERb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW369Ra01 Monoclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IP.
PAW369Ra01 Polyclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IF.
Assay Kits CLW369Ra01 CLIA Kit for Estrogen Receptor Beta (ERb) CLIA assay for Antigen Detection
ELW369Ra01 ELISA Kit for Estrogen Receptor Beta (ERb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW369Ca01 Recombinant Estrogen Receptor Beta (ERb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW369Ca01 Monoclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IP.
PAW369Ca01 Polyclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IF.
Assay Kits CLW369Ca01 CLIA Kit for Estrogen Receptor Beta (ERb) CLIA assay for Antigen Detection
ELW369Ca01 ELISA Kit for Estrogen Receptor Beta (ERb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW369Po01 Recombinant Estrogen Receptor Beta (ERb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW369Po01 Monoclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IP.
PAW369Po01 Polyclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IF.
Assay Kits CLW369Po01 CLIA Kit for Estrogen Receptor Beta (ERb) CLIA assay for Antigen Detection
ELW369Po01 ELISA Kit for Estrogen Receptor Beta (ERb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW369Bo01 Recombinant Estrogen Receptor Beta (ERb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW369Bo01 Monoclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IP.
PAW369Bo01 Polyclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IF.
Assay Kits CLW369Bo01 CLIA Kit for Estrogen Receptor Beta (ERb) CLIA assay for Antigen Detection
ELW369Bo01 ELISA Kit for Estrogen Receptor Beta (ERb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW369Rb01 Recombinant Estrogen Receptor Beta (ERb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW369Rb01 Monoclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IP.
PAW369Rb01 Polyclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IF.
Assay Kits CLW369Rb01 CLIA Kit for Estrogen Receptor Beta (ERb) CLIA assay for Antigen Detection
ELW369Rb01 ELISA Kit for Estrogen Receptor Beta (ERb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW369Mo01 Recombinant Estrogen Receptor Beta (ERb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW369Mo01 Monoclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IP.
PAW369Mo01 Polyclonal Antibody to Estrogen Receptor Beta (ERb) WB; IHC; ICC; IF.
Assay Kits CLW369Mo01 CLIA Kit for Estrogen Receptor Beta (ERb) CLIA assay for Antigen Detection
ELW369Mo01 ELISA Kit for Estrogen Receptor Beta (ERb) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The complete primary structure of human estrogen receptor beta (hERbeta) and its heterodimerization with ER alpha in vivo and in vitro."
Biochem. Biophys. Res. Commun. 243:122-126(1998) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of human estrogen receptor beta isoforms."
Biochem. Biophys. Res. Commun. 247:75-78(1998) [PubMed] [Europe PMC] [Abstract]

"Estrogen receptor-beta mRNA variants in human and murine tissues."
Mol. Cell. Endocrinol. 138:199-203(1998) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and characterization of human estrogen receptor beta cx: a potential inhibitor of estrogen action in human."
Nucleic Acids Res. 26:3505-3512(1998) [PubMed] [Europe PMC] [Abstract]

"Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling."
Proc. Natl. Acad. Sci. U.S.A. 103:13162-13167(2006) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of human estrogen receptor beta promoter."
Biochem. Biophys. Res. Commun. 275:682-689(2000) [PubMed] [Europe PMC] [Abstract]

"ER beta: identification and characterization of a novel human estrogen receptor."
FEBS Lett. 392:49-53(1996) [PubMed] [Europe PMC] [Abstract]

"Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300."
Cell 90:569-580(1997) [PubMed] [Europe PMC] [Abstract]

"Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha."
J. Biol. Chem. 272:25832-25838(1997) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of RAP250, a nuclear receptor coactivator."
J. Biol. Chem. 275:5308-5317(2000) [PubMed] [Europe PMC] [Abstract]

"CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant."
Mol. Cell. Biol. 21:343-353(2001) [PubMed] [Europe PMC] [Abstract]

"The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway."
J. Biol. Chem. 276:46792-46797(2001) [PubMed] [Europe PMC] [Abstract]

"Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha."
J. Biol. Chem. 277:28624-28630(2002) [PubMed] [Europe PMC] [Abstract]

"Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade."
Proc. Natl. Acad. Sci. U.S.A. 99:14783-14788(2002) [PubMed] [Europe PMC] [Abstract]

"ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor."
Biochem. Biophys. Res. Commun. 317:54-59(2004) [PubMed] [Europe PMC] [Abstract]

"An unappreciated role for RNA surveillance."
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]

"An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling."
J. Biol. Chem. 279:38721-38729(2004) [PubMed] [Europe PMC] [Abstract]

"Selective hormone-dependent repression of estrogen receptor beta by a p38-activated ErbB2/ErbB3 pathway."
J. Steroid Biochem. Mol. Biol. 94:23-37(2005) [PubMed] [Europe PMC] [Abstract]

"CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells."
Carcinogenesis 30:841-850(2009) [PubMed] [Europe PMC] [Abstract]