Apoptosis Antagonizing Transcription Factor (AATF)

CHE1; DED; Rb-binding protein Che-1

SPN	W366
HGNC	19235
MGI	1929608
PubMed	15207272
RGD	620685
UniProt	Q9NY61
Wiki	AATF

Protein AATF  was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.By differential display for genes downregulated by TGFB in an intestinal crypt epithelial cell line, Lindfors et al. (2000) cloned AATF.The AATF transcript contains several 4-nucleotide repeats, and the deduced 560-amino acid protein contains a leucine zipper motif, several phosphorylation sites, a nuclear localization signal, and 3 nuclear receptor LxxLL binding motifs.

Reference

"Identification of novel transcription factor-like gene from human intestinal cells."
Biochem. Biophys. Res. Commun. 276:660-666(2000) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb."
FASEB J. 14:904-912(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb."
Cancer Cell 2:387-399(2002) [PubMed] [Europe PMC] [Abstract]

"Functional proteomic analysis of human nucleolus."
Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]

"Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter."
J. Biol. Chem. 278:36496-36504(2003) [PubMed] [Europe PMC] [Abstract]

"Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis."
Mol. Cell. Neurosci. 24:1038-1050(2003) [PubMed] [Europe PMC] [Abstract]

"AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4."
J. Biol. Chem. 279:4596-4603(2004) [PubMed] [Europe PMC] [Abstract]

"AATF protects neural cells against oxidative damage induced by amyloid beta-peptide."
Neurobiol. Dis. 16:150-157(2004) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]