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Prohibitin (PHB)

SPN W364
HGNC 8912
MGI 97572
PubMed 16041367
RGD 3322
UniProt P35232
Wiki Prohibitin

Prohibitin is a protein which in humans is encoded by the PHB gene. The Phb gene has also been described in animals, fungi, plants and unicellular eukaryotes. Prohibitins are divided in two classes, termed Type-I and Type-II prohibitins, based on their similarity to yeast PHB1 or PHB2, respectively.

Each organism has at least one copy of each type of prohibitin gene.Prohibitins are evolutionarily conserved genes that are ubiquitously expressed. The human prohibitin gene, located on the BRCA1 chromosome region 17q21, was originally thought to be a negative regulator of cell proliferation and a tumor suppressor. This anti-proliferative activity was later attributed to the 3' UTR of the PHB gene, and not to the actual protein.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW364Hu01 Recombinant Prohibitin (PHB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW364Hu01 Monoclonal Antibody to Prohibitin (PHB) WB; IHC; ICC; IP.
PAW364Hu01 Polyclonal Antibody to Prohibitin (PHB) WB; IHC; ICC; IF.
Assay Kits CLW364Hu01 CLIA Kit for Prohibitin (PHB) CLIA assay for Antigen Detection
ELW364Hu01 ELISA Kit for Prohibitin (PHB) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW364Mu01 Recombinant Prohibitin (PHB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW364Mu01 Monoclonal Antibody to Prohibitin (PHB) WB; IHC; ICC; IP.
PAW364Mu01 Polyclonal Antibody to Prohibitin (PHB) WB; IHC; ICC; IF.
Assay Kits CLW364Mu01 CLIA Kit for Prohibitin (PHB) CLIA assay for Antigen Detection
ELW364Mu01 ELISA Kit for Prohibitin (PHB) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW364Ra01 Recombinant Prohibitin (PHB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW364Ra01 Monoclonal Antibody to Prohibitin (PHB) WB; IHC; ICC; IP.
PAW364Ra01 Polyclonal Antibody to Prohibitin (PHB) WB; IHC; ICC; IF.
Assay Kits CLW364Ra01 CLIA Kit for Prohibitin (PHB) CLIA assay for Antigen Detection
ELW364Ra01 ELISA Kit for Prohibitin (PHB) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW364Ca01 Recombinant Prohibitin (PHB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW364Ca01 Monoclonal Antibody to Prohibitin (PHB) WB; IHC; ICC; IP.
PAW364Ca01 Polyclonal Antibody to Prohibitin (PHB) WB; IHC; ICC; IF.
Assay Kits CLW364Ca01 CLIA Kit for Prohibitin (PHB) CLIA assay for Antigen Detection
ELW364Ca01 ELISA Kit for Prohibitin (PHB) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW364Po01 Recombinant Prohibitin (PHB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW364Po01 Monoclonal Antibody to Prohibitin (PHB) WB; IHC; ICC; IP.
PAW364Po01 Polyclonal Antibody to Prohibitin (PHB) WB; IHC; ICC; IF.
Assay Kits CLW364Po01 CLIA Kit for Prohibitin (PHB) CLIA assay for Antigen Detection
ELW364Po01 ELISA Kit for Prohibitin (PHB) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW364Bo01 Recombinant Prohibitin (PHB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW364Bo01 Monoclonal Antibody to Prohibitin (PHB) WB; IHC; ICC; IP.
PAW364Bo01 Polyclonal Antibody to Prohibitin (PHB) WB; IHC; ICC; IF.
Assay Kits CLW364Bo01 CLIA Kit for Prohibitin (PHB) CLIA assay for Antigen Detection
ELW364Bo01 ELISA Kit for Prohibitin (PHB) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW364Rb01 Recombinant Prohibitin (PHB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW364Rb01 Monoclonal Antibody to Prohibitin (PHB) WB; IHC; ICC; IP.
PAW364Rb01 Polyclonal Antibody to Prohibitin (PHB) WB; IHC; ICC; IF.
Assay Kits CLW364Rb01 CLIA Kit for Prohibitin (PHB) CLIA assay for Antigen Detection
ELW364Rb01 ELISA Kit for Prohibitin (PHB) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW364Mo01 Recombinant Prohibitin (PHB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW364Mo01 Monoclonal Antibody to Prohibitin (PHB) WB; IHC; ICC; IP.
PAW364Mo01 Polyclonal Antibody to Prohibitin (PHB) WB; IHC; ICC; IF.
Assay Kits CLW364Mo01 CLIA Kit for Prohibitin (PHB) CLIA assay for Antigen Detection
ELW364Mo01 ELISA Kit for Prohibitin (PHB) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer."
Cancer Res. 52:1643-1646(1992) [PubMed] [Europe PMC] [Abstract]

"The human prohibitin (PHB) gene family and its somatic mutations in human tumors."
Genomics 17:762-764(1993) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

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