Kallikrein 5 (KLK5)

KLK-L2; KLKL2; SCTE; Kallikrein-Related Peptidase 5; Kallikrein-like protein 2; Stratum corneum tryptic enzyme

SPN	W355
HGNC	6366
MGI	1915918
PubMed	19820362
RGD	1593461
UniProt	Q9Y337
Wiki	KLK5

KLK5 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues. For background information on kallikreins.Using a positional candidate approach to identify additional KLK genes on 19q13.3-q13.4, followed by EST database searching and PCR, Yousef and Diamandis (1999) obtained a cDNA encoding KLK5, which they called KLKL2. RT-PCR analysis detected expression primarily in brain, mammary gland, and testis, with lower levels in other tissues.Kim et al. (2001) noted that KLK5 is expressed in a subset of ovarian tumors. They found a strong positive correlation between KLK5 expression and tumor grade and disease stage. They concluded that KLK5 expression is associated with more aggressive forms of epithelial ovarian carcinoma.

Reference

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J. Biol. Chem. 274:30033-30040(1999) [PubMed] [Europe PMC] [Abstract]

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Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]

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J. Invest. Dermatol. 129:1656-1665(2009) [PubMed] [Europe PMC] [Abstract]

"Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor."
PLoS ONE 4:E4372-E4372(2009) [PubMed] [Europe PMC] [Abstract]

"Structural basis of the zinc inhibition of human tissue kallikrein 5."
J. Mol. Biol. 373:1017-1031(2007) [PubMed] [Europe PMC] [Abstract]