Caspase 14 (CASP14)

Caspase 14 Apoptosis-Related Cysteine Peptidase; Cysteinyl Aspartate Specific Proteinases 14

SPN	W349
HGNC	1502
MGI	1335092
PubMed	12445205
RGD	1311781
UniProt	P31944
Wiki	Caspase_14

Caspase-14 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.

Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.

Reference

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Biochem. Biophys. Res. Commun. 277:655-659(2000) [PubMed] [Europe PMC] [Abstract]

"Expression and transcriptional regulation of caspase-14 in simple and complex epithelia."
Cell Death Differ. 9:995-1006(2002) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]

"Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing."
Cell Death Differ. 7:1218-1224(2000) [PubMed] [Europe PMC] [Abstract]

"Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation."
Biochem. Biophys. Res. Commun. 296:911-917(2002) [PubMed] [Europe PMC] [Abstract]

"Activation and substrate specificity of caspase-14."
Biochemistry 43:10560-10569(2004) [PubMed] [Europe PMC] [Abstract]

"Stratum corneum-derived caspase-14 is catalytically active."
FEBS Lett. 577:446-450(2004) [PubMed] [Europe PMC] [Abstract]

"Expression and characterization of constitutively active human caspase-14."
Biochem. Biophys. Res. Commun. 347:941-948(2006) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of active caspase-14 from human epidermis and development of the cleavage site-directed antibody."
J. Cell. Biochem. 109:487-497(2010) [PubMed] [Europe PMC] [Abstract]

"Kallikrein-related peptidase-7 regulates caspase-14 maturation during keratinocyte terminal differentiation by generating an intermediate form."
J. Biol. Chem. 287:32825-32834(2012) [PubMed] [Europe PMC] [Abstract]

"Caspase-14 expression impairs retinal pigment epithelium barrier function: potential role in diabetic macular edema."
Biomed. Res. Int. 2014:417986-417986(2014) [PubMed] [Europe PMC] [Abstract]

"Multiple pathways are involved in DNA degradation during keratinocyte terminal differentiation."
Cell Death Dis. 5:E1181-E1181(2014) [PubMed] [Europe PMC] [Abstract]