Decay Accelerating Factor (DAF)

CD55; CR; TC; Complement decay-accelerating factor

SPN	W338
HGNC	2665
MGI	104850
PubMed	7511675
RGD	620651
UniProt	P08174
Wiki	DAF

Decay accelerating factor is a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating factor (DAF); binding of DAF to complement proteins accelerates their decay, disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. Additional, alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Reference

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Nature 325:545-549(1987) [PubMed] [Europe PMC] [Abstract]

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Proc. Natl. Acad. Sci. U.S.A. 84:2007-2011(1987) [PubMed] [Europe PMC] [Abstract]

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"Decay-accelerating factor CD55 is identified as the receptor for echovirus 7 using CELICS, a rapid immuno-focal cloning method."
EMBO J. 13:5070-5074(1994) [PubMed] [Europe PMC] [Abstract]

"Decay-accelerating factor (CD55), a glycosylphosphatidylinositol-anchored complement regulatory protein, is a receptor for several echoviruses."
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"Coxsackieviruses B1, B3, and B5 use decay accelerating factor as a receptor for cell attachment."
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"The HeLa cell receptor for enterovirus 70 is decay-accelerating factor (CD55)."
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"Coxsackievirus A21 binds to decay-accelerating factor but requires intercellular adhesion molecule 1 for cell entry."
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