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Lipase, Endothelial (LIPG)
Lipase, Endothelial (LIPG)
EL; EDL; Endothelial Lipase; Endothelial cell-derived lipase
Endothelial lipase (EL) was initially cloned by both of these laboratories using entirely different strategies. Endothelial lipase was identified as a transcript that was upregulated in cultured rat umbilical vein endothelial cells undergoing tube formation, whereas the Rader group cloned endothelial lipase as a transcript that was upregulated in the rat macrophage-like cell line THP-1 exposed to oxidized LDL. Database searches revealed that endothelial lipase shows strong sequence similarity to lipoprotein lipase (44 percent identity) and hepatic lipase (41 percent identity), two well-characterized lipases that function at vascular endothelial surfaces. Critical motifs associated with lipase activity (GXSXG and the catalytic triad S169, D193, H274), and with heparin binding were strongly conserved.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
W337Hu01
Recombinant Lipase, Endothelial (LIPG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipase, Endothelial (LIPG) Bioactivity
Antibodies
MW337Hu22
Monoclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IP.
PW337Hu01
Polyclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IF.
LW337Hu71
Biotin Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry
LW337Hu81
FITC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry;ICC/IF
Assay Kits
KEW337Hu
ELISA Kit for Lipase, Endothelial (LIPG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipase, Endothelial (LIPG) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
W337Mu01
Recombinant Lipase, Endothelial (LIPG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipase, Endothelial (LIPG) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IP.
PW337Mu01
Polyclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry;ICC/IF
Assay Kits
KEW337Mu
ELISA Kit for Lipase, Endothelial (LIPG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipase, Endothelial (LIPG) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
W337Ra01
Recombinant Lipase, Endothelial (LIPG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipase, Endothelial (LIPG) Bioactivity
Antibodies
MW337Ra21
Monoclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IP.
PW337Ra01
Polyclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry;ICC/IF
Assay Kits
KEW337Ra
ELISA Kit for Lipase, Endothelial (LIPG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipase, Endothelial (LIPG) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipase, Endothelial (LIPG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipase, Endothelial (LIPG) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipase, Endothelial (LIPG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipase, Endothelial (LIPG) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipase, Endothelial (LIPG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipase, Endothelial (LIPG) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipase, Endothelial (LIPG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipase, Endothelial (LIPG) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipase, Endothelial (LIPG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipase, Endothelial (LIPG) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipase, Endothelial (LIPG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipase, Endothelial (LIPG) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipase, Endothelial (LIPG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipase, Endothelial (LIPG) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipase, Endothelial (LIPG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipase, Endothelial (LIPG) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipase, Endothelial (LIPG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipase, Endothelial (LIPG) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipase, Endothelial (LIPG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipase, Endothelial (LIPG) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipase, Endothelial (LIPG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipase, Endothelial (LIPG) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipase, Endothelial (LIPG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipase, Endothelial (LIPG) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipase, Endothelial (LIPG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipase, Endothelial (LIPG) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipase, Endothelial (LIPG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipase, Endothelial (LIPG) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipase, Endothelial (LIPG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipase, Endothelial (LIPG) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipase, Endothelial (LIPG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipase, Endothelial (LIPG) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipase, Endothelial (LIPG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipase, Endothelial (LIPG) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipase, Endothelial (LIPG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipase, Endothelial (LIPG) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipase, Endothelial (LIPG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipase, Endothelial (LIPG) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipase, Endothelial (LIPG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipase, Endothelial (LIPG) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lipase, Endothelial (LIPG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lipase, Endothelial (LIPG) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lipase, Endothelial (LIPG) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lipase, Endothelial (LIPG) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lipase, Endothelial (LIPG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lipase, Endothelial (LIPG) CLIA assay for Antigen Detection
Reference
"Cloning of a unique lipase from endothelial cells extends the lipase gene family." J. Biol. Chem. 274:14170-14175(1999) [PubMed ] [Europe PMC ] [Abstract ]
"A novel endothelial-derived lipase that modulates HDL metabolism." Nat. Genet. 21:424-428(1999) [PubMed ] [Europe PMC ] [Abstract ]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Characterization of the lipolytic activity of endothelial lipase." PubMed ] [Europe PMC ] [Abstract ]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." J. Proteome Res. 4:2070-2080(2005) [PubMed ] [Europe PMC ] [Abstract ]
"Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation." J. Biol. Chem. 284:23322-23330(2009) [PubMed ] [Europe PMC ] [Abstract ]
"Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors." Hum. Mol. Genet. 12:2733-2743(2003) [PubMed ] [Europe PMC ] [Abstract ]
