Call Now

Troponin I Type 3, Cardiac (TNNI3)

cTnI; TNNC1; CMH7; C-TnI; Troponin I Type 3; Cardiac troponin I

Troponin I is part of a heteromeric complex playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, troponin I (TnI), troponin T (TnT) and troponin C (TnC). Each subunit is responsible for part of troponin complex function. TnI inhibits ATPase activity of acto myosin and TnT and TnI are present in cardiac muscles in different forms than in skeletal muscles. Only one tissue specific isoform of TnI is described for cardiac muscle tissue (cTnI) and this is expressed only in myocardium.Equally reactive with free cardiac troponin I (cTnI) and cTnI forming complexes with other troponin components. (In the presence of 5 mM EDTA). Antibodies are not affected by heparin, phosphorylation, oxidation and troponin complex formation. No cross-reaction with skeletal muscle troponin I.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW328Hu01 Recombinant Troponin I Type 3, Cardiac (TNNI3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW328Hu01 Monoclonal Antibody to Troponin I Type 3, Cardiac (TNNI3) WB; IHC; ICC; IP.
PAW328Hu01 Polyclonal Antibody to Troponin I Type 3, Cardiac (TNNI3) WB; IHC; ICC; IF.
Assay Kits CLW328Hu01 CLIA Kit for Troponin I Type 3, Cardiac (TNNI3) CLIA assay for Antigen Detection
ELW328Hu01 ELISA Kit for Troponin I Type 3, Cardiac (TNNI3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW328Mu01 Recombinant Troponin I Type 3, Cardiac (TNNI3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW328Mu01 Monoclonal Antibody to Troponin I Type 3, Cardiac (TNNI3) WB; IHC; ICC; IP.
PAW328Mu01 Polyclonal Antibody to Troponin I Type 3, Cardiac (TNNI3) WB; IHC; ICC; IF.
Assay Kits CLW328Mu01 CLIA Kit for Troponin I Type 3, Cardiac (TNNI3) CLIA assay for Antigen Detection
ELW328Mu01 ELISA Kit for Troponin I Type 3, Cardiac (TNNI3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW328Ra01 Recombinant Troponin I Type 3, Cardiac (TNNI3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW328Ra01 Monoclonal Antibody to Troponin I Type 3, Cardiac (TNNI3) WB; IHC; ICC; IP.
PAW328Ra01 Polyclonal Antibody to Troponin I Type 3, Cardiac (TNNI3) WB; IHC; ICC; IF.
Assay Kits CLW328Ra01 CLIA Kit for Troponin I Type 3, Cardiac (TNNI3) CLIA assay for Antigen Detection
ELW328Ra01 ELISA Kit for Troponin I Type 3, Cardiac (TNNI3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW328Ca01 Recombinant Troponin I Type 3, Cardiac (TNNI3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW328Ca01 Monoclonal Antibody to Troponin I Type 3, Cardiac (TNNI3) WB; IHC; ICC; IP.
PAW328Ca01 Polyclonal Antibody to Troponin I Type 3, Cardiac (TNNI3) WB; IHC; ICC; IF.
Assay Kits CLW328Ca01 CLIA Kit for Troponin I Type 3, Cardiac (TNNI3) CLIA assay for Antigen Detection
ELW328Ca01 ELISA Kit for Troponin I Type 3, Cardiac (TNNI3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW328Po01 Recombinant Troponin I Type 3, Cardiac (TNNI3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW328Po01 Monoclonal Antibody to Troponin I Type 3, Cardiac (TNNI3) WB; IHC; ICC; IP.
PAW328Po01 Polyclonal Antibody to Troponin I Type 3, Cardiac (TNNI3) WB; IHC; ICC; IF.
Assay Kits CLW328Po01 CLIA Kit for Troponin I Type 3, Cardiac (TNNI3) CLIA assay for Antigen Detection
ELW328Po01 ELISA Kit for Troponin I Type 3, Cardiac (TNNI3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW328Bo01 Recombinant Troponin I Type 3, Cardiac (TNNI3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW328Bo01 Monoclonal Antibody to Troponin I Type 3, Cardiac (TNNI3) WB; IHC; ICC; IP.
PAW328Bo01 Polyclonal Antibody to Troponin I Type 3, Cardiac (TNNI3) WB; IHC; ICC; IF.
Assay Kits CLW328Bo01 CLIA Kit for Troponin I Type 3, Cardiac (TNNI3) CLIA assay for Antigen Detection
ELW328Bo01 ELISA Kit for Troponin I Type 3, Cardiac (TNNI3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW328Rb01 Recombinant Troponin I Type 3, Cardiac (TNNI3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW328Rb01 Monoclonal Antibody to Troponin I Type 3, Cardiac (TNNI3) WB; IHC; ICC; IP.
PAW328Rb01 Polyclonal Antibody to Troponin I Type 3, Cardiac (TNNI3) WB; IHC; ICC; IF.
Assay Kits CLW328Rb01 CLIA Kit for Troponin I Type 3, Cardiac (TNNI3) CLIA assay for Antigen Detection
ELW328Rb01 ELISA Kit for Troponin I Type 3, Cardiac (TNNI3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW328Mo01 Recombinant Troponin I Type 3, Cardiac (TNNI3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW328Mo01 Monoclonal Antibody to Troponin I Type 3, Cardiac (TNNI3) WB; IHC; ICC; IP.
PAW328Mo01 Polyclonal Antibody to Troponin I Type 3, Cardiac (TNNI3) WB; IHC; ICC; IF.
Assay Kits CLW328Mo01 CLIA Kit for Troponin I Type 3, Cardiac (TNNI3) CLIA assay for Antigen Detection
ELW328Mo01 ELISA Kit for Troponin I Type 3, Cardiac (TNNI3) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning of human cardiac troponin I using polymerase chain reaction."
FEBS Lett. 270:57-61(1990) [PubMed] [Europe PMC] [Abstract]

"Cloning and expression in Escherichia coli of the cDNA encoding human cardiac troponin I."
Gene 131:287-292(1993) [PubMed] [Europe PMC] [Abstract]

"Troponin I isoform expression in human heart."
Circ. Res. 69:1409-1414(1991) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of the human cardiac troponin I gene (TNNI3)."
Genomics 35:11-23(1996) [PubMed] [Europe PMC] [Abstract]

"A common motif of two adjacent phosphoserines in bovine, rabbit and human cardiac troponin I."
FEBS Lett. 273:41-45(1990) [PubMed] [Europe PMC] [Abstract]

"The ordered phosphorylation of cardiac troponin I by the cAMP-dependent protein kinase -- structural consequences and functional implications."
Eur. J. Biochem. 248:329-337(1997) [PubMed] [Europe PMC] [Abstract]

"p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I."
Circ. Res. 91:509-516(2002) [PubMed] [Europe PMC] [Abstract]

"Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function."
Circ. Res. 95:1091-1099(2004) [PubMed] [Europe PMC] [Abstract]

"Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I."
Proc. Natl. Acad. Sci. U.S.A. 101:18135-18140(2004) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1."
Biochem. J. 418:93-101(2009) [PubMed] [Europe PMC] [Abstract]

"Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart."
Circulation 126:1828-1837(2012) [PubMed] [Europe PMC] [Abstract]

"Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C."
Biochemistry 38:8289-8298(1999) [PubMed] [Europe PMC] [Abstract]

"Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil."
J. Biol. Chem. 277:31124-31133(2002) [PubMed] [Europe PMC] [Abstract]

"Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy."
Nat. Genet. 16:379-382(1997) [PubMed] [Europe PMC] [Abstract]

"Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly."
Circulation 105:446-451(2002) [PubMed] [Europe PMC] [Abstract]

"Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations."
J. Clin. Invest. 111:209-216(2003) [PubMed] [Europe PMC] [Abstract]

"Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy."
Circulation 107:2227-2232(2003) [PubMed] [Europe PMC] [Abstract]

Erratum
Circulation 109:3258-3258(2004)

"Mutation spectrum in a large cohort of unrelated consecutive patients with hypertrophic cardiomyopathy."
Clin. Genet. 64:339-349(2003) [PubMed] [Europe PMC] [Abstract]

"Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy."
Lancet 363:371-372(2004) [PubMed] [Europe PMC] [Abstract]

"Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling."
J. Med. Genet. 42:E59-E59(2005) [PubMed] [Europe PMC] [Abstract]

"Identification and functional characterization of cardiac troponin I as a novel disease gene in autosomal dominant dilated cardiomyopathy."
Circ. Res. 105:375-382(2009) [PubMed] [Europe PMC] [Abstract]

"Clinical and mutational spectrum in a cohort of 105 unrelated patients with dilated cardiomyopathy."
Eur. J. Med. Genet. 54:E570-E575(2011) [PubMed] [Europe PMC] [Abstract]