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Endothelin 1 (EDN1)

ET1; PPET1; Preproendothelin-1; Big endothelin-1

Endothelin-1(ET-1), a peptide of 21 amino acid residues, is the most potent vasoconstrictive substance known. Originally isolated from porcine aortic endothelial cells, ET-1 is now known to be one of a family of three mammalian vasoactive peptides that also includes Endothelin-2 (ET-2) and Endothelin-3 (ET-3). These related peptides differ from ET-1 at two and six amino acid residue positions, respectively. A fourth peptide, vasoactive intestinal contractor (VIC), is sometimes classified as rat ET-2. All members of the endothelin family contain two essential disulfide bridges and six conserved amino acid residues at the C-terminus. Additionally, all of the endothelin family members are synthesized initially as prepropolypeptides of approximately 200 amino acid residues encoded by separate genes.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW324Hu01 Recombinant Endothelin 1 (EDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW324Hu01 Monoclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
PAW324Hu01 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IF.
Assay Kits CLW324Hu01 CLIA Kit for Endothelin 1 (EDN1) CLIA assay for Antigen Detection
ELW324Hu01 ELISA Kit for Endothelin 1 (EDN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW324Mu01 Recombinant Endothelin 1 (EDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW324Mu01 Monoclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
PAW324Mu01 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IF.
Assay Kits CLW324Mu01 CLIA Kit for Endothelin 1 (EDN1) CLIA assay for Antigen Detection
ELW324Mu01 ELISA Kit for Endothelin 1 (EDN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW324Ra01 Recombinant Endothelin 1 (EDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW324Ra01 Monoclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
PAW324Ra01 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IF.
Assay Kits CLW324Ra01 CLIA Kit for Endothelin 1 (EDN1) CLIA assay for Antigen Detection
ELW324Ra01 ELISA Kit for Endothelin 1 (EDN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW324Ca01 Recombinant Endothelin 1 (EDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW324Ca01 Monoclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
PAW324Ca01 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IF.
Assay Kits CLW324Ca01 CLIA Kit for Endothelin 1 (EDN1) CLIA assay for Antigen Detection
ELW324Ca01 ELISA Kit for Endothelin 1 (EDN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW324Po01 Recombinant Endothelin 1 (EDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW324Po01 Monoclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
PAW324Po01 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IF.
Assay Kits CLW324Po01 CLIA Kit for Endothelin 1 (EDN1) CLIA assay for Antigen Detection
ELW324Po01 ELISA Kit for Endothelin 1 (EDN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW324Bo01 Recombinant Endothelin 1 (EDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW324Bo01 Monoclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
PAW324Bo01 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IF.
Assay Kits CLW324Bo01 CLIA Kit for Endothelin 1 (EDN1) CLIA assay for Antigen Detection
ELW324Bo01 ELISA Kit for Endothelin 1 (EDN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW324Rb01 Recombinant Endothelin 1 (EDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW324Rb01 Monoclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
PAW324Rb01 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IF.
Assay Kits CLW324Rb01 CLIA Kit for Endothelin 1 (EDN1) CLIA assay for Antigen Detection
ELW324Rb01 ELISA Kit for Endothelin 1 (EDN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW324Mo01 Recombinant Endothelin 1 (EDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW324Mo01 Monoclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IP.
PAW324Mo01 Polyclonal Antibody to Endothelin 1 (EDN1) WB; IHC; ICC; IF.
Assay Kits CLW324Mo01 CLIA Kit for Endothelin 1 (EDN1) CLIA assay for Antigen Detection
ELW324Mo01 ELISA Kit for Endothelin 1 (EDN1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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FEBS Lett. 231:440-444(1988) [PubMed] [Europe PMC] [Abstract]

"The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression."
J. Biol. Chem. 264:14954-14959(1989) [PubMed] [Europe PMC] [Abstract]

"Structural organization and chromosomal assignment of the gene encoding endothelin."
J. Biol. Chem. 264:10851-10857(1989) [PubMed] [Europe PMC] [Abstract]

"Two preproendothelin 1 mRNAs transcribed by alternative promoters."
J. Clin. Invest. 91:1149-1156(1993) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes."
Proc. Natl. Acad. Sci. U.S.A. 86:2863-2867(1989) [PubMed] [Europe PMC] [Abstract]

"Proteolytic processing of big endothelin-3 by the kell blood group protein."
Blood 94:1440-1450(1999) [PubMed] [Europe PMC] [Abstract]

"The signal peptide of human preproendothelin-1."
FEBS Lett. 286:91-94(1991) [PubMed] [Europe PMC] [Abstract]

"Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3."
J. Clin. Endocrinol. Metab. 82:3116-3123(1997) [PubMed] [Europe PMC] [Abstract]

"Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol."
Am. J. Hum. Genet. 80:673-682(2007) [PubMed] [Europe PMC] [Abstract]

"Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease."
Hum. Genet. 123:307-313(2008) [PubMed] [Europe PMC] [Abstract]

"Crystallization and preliminary X-ray analysis of human endothelin."
Acta Crystallogr. B 48:239-240(1992) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of human endothelin."
Nat. Struct. Biol. 1:311-319(1994) [PubMed] [Europe PMC] [Abstract]

"The conformation of endothelin-1 in aqueous solution: NMR-derived constraints combined with distance geometry and molecular dynamics calculations."
Biochem. Biophys. Res. Commun. 178:570-577(1991) [PubMed] [Europe PMC] [Abstract]

"Conformational isomerism of endothelin in acidic aqueous media: a quantitative NOESY analysis."
Biochemistry 31:1280-1295(1992) [PubMed] [Europe PMC] [Abstract]

"Solution conformation of human big endothelin-1."
J. Biomol. NMR 2:407-420(1992) [PubMed] [Europe PMC] [Abstract]

"A comparison of X-ray and NMR structures for human endothelin-1."
Protein Sci. 4:75-83(1995) [PubMed] [Europe PMC] [Abstract]

"Solution structure of a novel ETB receptor selective agonist ET1-21 [Cys(Acm)1,15, Aib3,11, Leu7] by nuclear magnetic resonance spectroscopy and molecular modelling."
J. Pept. Res. 53:223-233(1999) [PubMed] [Europe PMC] [Abstract]

"The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people."
Hypertension 33:1169-1174(1999) [PubMed] [Europe PMC] [Abstract]

"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]

"Mutations in endothelin 1 cause recessive auriculocondylar syndrome and dominant isolated question-mark ears."
Am. J. Hum. Genet. 93:1118-1125(2013) [PubMed] [Europe PMC] [Abstract]