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Keratin 3 (KRT3)

CK3; K3; Cytokeratin 3; Keratin, type II cytoskeletal 3; 65 kDa cytokeratin; Type-II keratin Kb3

SPN W317
HGNC 6440
PubMed 16227835
UniProt P12035
Wiki Keratin_3

  • Specific pairs of heterotypic keratin chains are coexpressed during the various stages of epithelial differentiation. This pattern of expression of cytokeratin pairs implies the existence of highly coordinated control of transcription. The gene for cytokeratin 3 (KRT3), a member of the type II subfamily, is expressed together with KRT12  during 'corneal-type' differentiation (Schermer et al., 1986).

  • The KRT3 gene is approximately 6.5 kb long and encodes one of the largest cytokeratin proteins (64 kD). By fluorescence in situ hybridization, Raimondi et al. (1994) mapped the KRT3 gene to 12q12-q13. All type II keratin genes mapped to that time had been assigned to chromosome 12 where they appeared to be organized into one homotypic cluster.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW317Hu01 Recombinant Keratin 3 (KRT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW317Hu01 Monoclonal Antibody to Keratin 3 (KRT3) WB; IHC; ICC; IP.
PAW317Hu01 Polyclonal Antibody to Keratin 3 (KRT3) WB; IHC; ICC; IF.
Assay Kits CLW317Hu01 CLIA Kit for Keratin 3 (KRT3) CLIA assay for Antigen Detection
ELW317Hu01 ELISA Kit for Keratin 3 (KRT3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW317Mu01 Recombinant Keratin 3 (KRT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW317Mu01 Monoclonal Antibody to Keratin 3 (KRT3) WB; IHC; ICC; IP.
PAW317Mu01 Polyclonal Antibody to Keratin 3 (KRT3) WB; IHC; ICC; IF.
Assay Kits CLW317Mu01 CLIA Kit for Keratin 3 (KRT3) CLIA assay for Antigen Detection
ELW317Mu01 ELISA Kit for Keratin 3 (KRT3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW317Ra01 Recombinant Keratin 3 (KRT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW317Ra01 Monoclonal Antibody to Keratin 3 (KRT3) WB; IHC; ICC; IP.
PAW317Ra01 Polyclonal Antibody to Keratin 3 (KRT3) WB; IHC; ICC; IF.
Assay Kits CLW317Ra01 CLIA Kit for Keratin 3 (KRT3) CLIA assay for Antigen Detection
ELW317Ra01 ELISA Kit for Keratin 3 (KRT3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW317Ca01 Recombinant Keratin 3 (KRT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW317Ca01 Monoclonal Antibody to Keratin 3 (KRT3) WB; IHC; ICC; IP.
PAW317Ca01 Polyclonal Antibody to Keratin 3 (KRT3) WB; IHC; ICC; IF.
Assay Kits CLW317Ca01 CLIA Kit for Keratin 3 (KRT3) CLIA assay for Antigen Detection
ELW317Ca01 ELISA Kit for Keratin 3 (KRT3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW317Po01 Recombinant Keratin 3 (KRT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW317Po01 Monoclonal Antibody to Keratin 3 (KRT3) WB; IHC; ICC; IP.
PAW317Po01 Polyclonal Antibody to Keratin 3 (KRT3) WB; IHC; ICC; IF.
Assay Kits CLW317Po01 CLIA Kit for Keratin 3 (KRT3) CLIA assay for Antigen Detection
ELW317Po01 ELISA Kit for Keratin 3 (KRT3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW317Bo01 Recombinant Keratin 3 (KRT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW317Bo01 Monoclonal Antibody to Keratin 3 (KRT3) WB; IHC; ICC; IP.
PAW317Bo01 Polyclonal Antibody to Keratin 3 (KRT3) WB; IHC; ICC; IF.
Assay Kits CLW317Bo01 CLIA Kit for Keratin 3 (KRT3) CLIA assay for Antigen Detection
ELW317Bo01 ELISA Kit for Keratin 3 (KRT3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW317Rb01 Recombinant Keratin 3 (KRT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW317Rb01 Monoclonal Antibody to Keratin 3 (KRT3) WB; IHC; ICC; IP.
PAW317Rb01 Polyclonal Antibody to Keratin 3 (KRT3) WB; IHC; ICC; IF.
Assay Kits CLW317Rb01 CLIA Kit for Keratin 3 (KRT3) CLIA assay for Antigen Detection
ELW317Rb01 ELISA Kit for Keratin 3 (KRT3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW317Mo01 Recombinant Keratin 3 (KRT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW317Mo01 Monoclonal Antibody to Keratin 3 (KRT3) WB; IHC; ICC; IP.
PAW317Mo01 Polyclonal Antibody to Keratin 3 (KRT3) WB; IHC; ICC; IF.
Assay Kits CLW317Mo01 CLIA Kit for Keratin 3 (KRT3) CLIA assay for Antigen Detection
ELW317Mo01 ELISA Kit for Keratin 3 (KRT3) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Evolution of keratin genes: different protein domains evolve by different pathways."
J. Mol. Evol. 24:319-329(1987) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13."
J. Invest. Dermatol. 124:536-544(2005) [PubMed] [Europe PMC] [Abstract]

"Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy."
Nat. Genet. 16:184-187(1997) [PubMed] [Europe PMC] [Abstract]

"Novel mutations in the helix termination motif of keratin 3 and keratin 12 in 2 Taiwanese families with Meesmann corneal dystrophy."
Cornea 24:928-932(2005) [PubMed] [Europe PMC] [Abstract]

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