Protein Kinase C Theta (PKCq)

PRKC-Q; PRKCQ; PRKCT; NPKC-Theta

SPN	W313
HGNC	9410
MGI	97601
PubMed	9021158
RGD	620968
UniProt	Q04759
Wiki	PRKCQ

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.

Reference

"Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets."
J. Biol. Chem. 268:14208-14214(1993) [PubMed] [Europe PMC] [Abstract]

Erratum
J. Biol. Chem. 269:31322-31322(1994) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells."
J. Biol. Chem. 268:4997-5004(1993) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes."
Mol. Cell. Biol. 16:1842-1850(1996) [PubMed] [Europe PMC] [Abstract]

"Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain."
J. Biol. Chem. 275:1902-1909(2000) [PubMed] [Europe PMC] [Abstract]

"Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation."
J. Biol. Chem. 275:3603-3609(2000) [PubMed] [Europe PMC] [Abstract]

"Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD."
J. Immunol. 166:5955-5963(2001) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction."
Biochem. J. 361:255-265(2002) [PubMed] [Europe PMC] [Abstract]

"SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway."
EMBO J. 23:1112-1122(2004) [PubMed] [Europe PMC] [Abstract]

"Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)."
J. Biol. Chem. 279:45304-45307(2004) [PubMed] [Europe PMC] [Abstract]

"Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity."
Mol. Cell. Biol. 24:6665-6675(2004) [PubMed] [Europe PMC] [Abstract]

"Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes."
EMBO J. 24:3869-3880(2005) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of the CARMA1 linker controls NF-kappaB activation."
Immunity 23:561-574(2005) [PubMed] [Europe PMC] [Abstract]

"Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL."
J. Immunol. 176:6709-6716(2006) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation."
Sci. Signal. 2:RA30-RA30(2009) [PubMed] [Europe PMC] [Abstract]

"Protein kinase C(theta) in T cell activation."
Annu. Rev. Immunol. 20:761-794(2002) [PubMed] [Europe PMC] [Abstract]

"Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death."
J. Biochem. 132:841-846(2002) [PubMed] [Europe PMC] [Abstract]

"Protein kinase C and beyond."
Nat. Immunol. 5:785-790(2004) [PubMed] [Europe PMC] [Abstract]

"Selective function of PKC-theta in T cells."
Cell. Mol. Immunol. 3:263-270(2006) [PubMed] [Europe PMC] [Abstract]

"Protein kinase C theta (PKCtheta): a key player in T cell life and death."
Pharmacol. Res. 55:537-544(2007) [PubMed] [Europe PMC] [Abstract]

"T-cell fate and function: PKC-theta and beyond."
Trends Immunol. 29:179-185(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Protein kinase C-theta in platelet activation."
FEBS Lett. 585:3208-3215(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Catalytic domain crystal structure of protein kinase C-theta (PKCtheta)."
J. Biol. Chem. 279:50401-50409(2004) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of the kinase domain of the protein kinase C theta in complex with Nvp-Xaa228."
Submitted (JAN-2007) to the PDB data bank

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]