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Protein Kinase N1 (PKN1)

PAK1; DBK; PRK1; PRKCL1; Protein Kinase C-Like 1; Protein kinase PKN-alpha; Protein-kinase C-related kinase 1; Serine-threonine protein kinase N

Serine/threonine-protein kinase N1 encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis.

The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Protein Kinase N1 (PKN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Protein Kinase N1 (PKN1) Bioactivity
Antibodies MW306Hu21 Monoclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IP.
PW306Hu01 Polyclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Protein Kinase N1 (PKN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Protein Kinase N1 (PKN1) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Protein Kinase N1 (PKN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Protein Kinase N1 (PKN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Protein Kinase N1 (PKN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Protein Kinase N1 (PKN1) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Protein Kinase N1 (PKN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Protein Kinase N1 (PKN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Protein Kinase N1 (PKN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Protein Kinase N1 (PKN1) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Protein Kinase N1 (PKN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Protein Kinase N1 (PKN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Protein Kinase N1 (PKN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Protein Kinase N1 (PKN1) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Protein Kinase N1 (PKN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Protein Kinase N1 (PKN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Protein Kinase N1 (PKN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Protein Kinase N1 (PKN1) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Protein Kinase N1 (PKN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Protein Kinase N1 (PKN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Protein Kinase N1 (PKN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Protein Kinase N1 (PKN1) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Protein Kinase N1 (PKN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Protein Kinase N1 (PKN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Protein Kinase N1 (PKN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Protein Kinase N1 (PKN1) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Protein Kinase N1 (PKN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Protein Kinase N1 (PKN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Protein Kinase N1 (PKN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Protein Kinase N1 (PKN1) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Protein Kinase N1 (PKN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Protein Kinase N1 (PKN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Protein Kinase N1 (PKN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Protein Kinase N1 (PKN1) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Protein Kinase N1 (PKN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Protein Kinase N1 (PKN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Protein Kinase N1 (PKN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Protein Kinase N1 (PKN1) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Protein Kinase N1 (PKN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Protein Kinase N1 (PKN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Protein Kinase N1 (PKN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Protein Kinase N1 (PKN1) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Protein Kinase N1 (PKN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Protein Kinase N1 (PKN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Protein Kinase N1 (PKN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Protein Kinase N1 (PKN1) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Protein Kinase N1 (PKN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Protein Kinase N1 (PKN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Protein Kinase N1 (PKN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Protein Kinase N1 (PKN1) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Protein Kinase N1 (PKN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Protein Kinase N1 (PKN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Protein Kinase N1 (PKN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Protein Kinase N1 (PKN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Protein Kinase N1 (PKN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Protein Kinase N1 (PKN1) CLIA assay for Antigen Detection

Reference

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"Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton."
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"A Salmonella type III secretion effector interacts with the mammalian serine/threonine protein kinase PKN1."
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"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
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"Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation."
Nat. Cell Biol. 10:53-60(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
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"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
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