Apolipoprotein A1 (APOA1)

Apo-A1; ApoA-1 Milano; ProapoA-I; Proapolipoprotein A-I; Truncated apolipoprotein A-I

SPN	W290
HGNC	600
MGI	88049
PubMed	16130094
RGD	2130
UniProt	P02647
Wiki	APOA1

Apolipoprotein A-I  the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters.

ApoA-I was also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.ApoA-1 Milano is a naturally occurring mutant of ApoA-I, found in a family descended from a single couple of the 18th century.

Reference

"Gene structure of human apolipoprotein A1."
Nucleic Acids Res. 11:2827-2837(1983) [PubMed] [Europe PMC] [Abstract]

"Nucleotide sequence of cloned cDNA of human apolipoprotein A-I."
Nucleic Acids Res. 11:3703-3715(1983) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of the human apolipoprotein A-I gene."
Proc. Natl. Acad. Sci. U.S.A. 80:6147-6151(1983) [PubMed] [Europe PMC] [Abstract]

"Isolation and DNA sequence of full-length cDNA and of the entire gene for human apolipoprotein AI -- discovery of a new genetic polymorphism in the apo AI gene."
DNA 3:309-317(1984) [PubMed] [Europe PMC] [Abstract]

"Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance."
Nucleic Acids Res. 12:3917-3932(1984) [PubMed] [Europe PMC] [Abstract]

"Nucleotide sequence and the encoded amino acids of human apolipoprotein A-I mRNA."
Proc. Natl. Acad. Sci. U.S.A. 81:66-70(1984) [PubMed] [Europe PMC] [Abstract]

"Tangier disease. The complete mRNA sequence encoding for preproapo-A-I."
J. Biol. Chem. 260:12810-12814(1985) [PubMed] [Europe PMC] [Abstract]

"Sequence and expression of Tangier apoA-I gene."
Eur. J. Biochem. 173:465-471(1988) [PubMed] [Europe PMC] [Abstract]

"Production of human recombinant proapolipoprotein A-I in Escherichia coli: purification and biochemical characterization."
DNA 8:429-436(1989) [PubMed] [Europe PMC] [Abstract]

"The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster."
Hum. Genet. 115:36-56(2004) [PubMed] [Europe PMC] [Abstract]

"Expression of human proapolipoprotein A-1."
Patent number EP0293357, 30-NOV-1988

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human plasma proapoA-I: isolation and amino-terminal sequence."
Biochem. Biophys. Res. Commun. 113:626-632(1983) [PubMed] [Europe PMC] [Abstract]

"The primary structure of human plasma high density apolipoprotein glutamine I (ApoA-I). II. The amino acid sequence and alignment of cyanogen bromide fragments IV, III, and I."
J. Biol. Chem. 250:2725-2738(1975) [PubMed] [Europe PMC] [Abstract]

"The amino acid sequence of human APOA-I, an apolipoprotein isolated from high density lipoproteins."
Biochem. Biophys. Res. Commun. 80:623-630(1978) [PubMed] [Europe PMC] [Abstract]

"Serum prostacyclin stabilizing factor is identical to apolipoprotein A-I (Apo A-I). A novel function of Apo A-I."
J. Clin. Invest. 82:803-807(1988) [PubMed] [Europe PMC] [Abstract]

"Identification of apolipoprotein A1 and immunoglobulin as components of a serum complex that mediates activation of human sperm motility."
Biochemistry 30:8986-8990(1991) [PubMed] [Europe PMC] [Abstract]

"Apolipoprotein A-I binds to a family of bovine seminal plasma proteins."
J. Biol. Chem. 264:16853-16857(1989) [PubMed] [Europe PMC] [Abstract]

"Similarity of cruzin, an inhibitor of Trypanosoma cruzi neuraminidase, to high-density lipoprotein."
Science 238:1417-1419(1987) [PubMed] [Europe PMC] [Abstract]

"The human myocardial two-dimensional gel protein database: update 1994."
Electrophoresis 15:1459-1465(1994) [PubMed] [Europe PMC] [Abstract]

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

"The apolipoprotein A-I binding protein of placenta and the SP-40,40 protein of human blood are different proteins which both bind to apolipoprotein A-I."
Biochim. Biophys. Acta 1086:255-260(1991) [PubMed] [Europe PMC] [Abstract]

, Submitted (DEC-2008) to UniProtKB

"Isolation and characterization of cDNA clones for human apolipoprotein A-I."
Proc. Natl. Acad. Sci. U.S.A. 79:6861-6865(1982) [PubMed] [Europe PMC] [Abstract]

"Human apolipoprotein A-I. Post-translational modification by fatty acid acylation."
J. Biol. Chem. 261:3911-3914(1986) [PubMed] [Europe PMC] [Abstract]

"Intracellular and extracellular processing of human apolipoprotein A-I: secreted apolipoprotein A-I isoprotein 2 is a propeptide."
Proc. Natl. Acad. Sci. U.S.A. 80:2574-2578(1983) [PubMed] [Europe PMC] [Abstract]

"The preferential site of non-enzymatic glycation of human apolipoprotein A-I in vivo."
Clin. Chim. Acta 217:193-198(1993) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I."
Genomics 79:693-702(2002) [PubMed] [Europe PMC] [Abstract]

"Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein."
J. Lipid Res. 44:349-355(2003) [PubMed] [Europe PMC] [Abstract]

"Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteins."
J. Lipid Res. 44:630-639(2003) [PubMed] [Europe PMC] [Abstract]

"NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24."
Biochem. Biophys. Res. Commun. 332:982-992(2005) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Secondary structure changes in ApoA-I Milano (R173C) are not accompanied by a decrease in protein stability or solubility."
PLoS ONE 9:E96150-E96150(2014) [PubMed] [Europe PMC] [Abstract]

"Conformation of human serum apolipoprotein A-I(166-185) in the presence of sodium dodecyl sulfate or dodecylphosphocholine by 1H-NMR and CD. Evidence for specific peptide-SDS interactions."
Biochim. Biophys. Acta 1301:174-184(1996) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation."
Proc. Natl. Acad. Sci. U.S.A. 94:12291-12296(1997) [PubMed] [Europe PMC] [Abstract]

"Autosomal dominant hypoalphalipoproteinemia due to a completely defective apolipoprotein A-I gene."
Biochem. Biophys. Res. Commun. 196:950-955(1993) [PubMed] [Europe PMC] [Abstract]

"Apolipoprotein A-I Q[-2]X causing isolated apolipoprotein A-I deficiency in a family with analphalipoproteinemia."
J. Clin. Invest. 93:223-229(1994) [PubMed] [Europe PMC] [Abstract]

"Apolipoprotein A-IMilano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I."
J. Biol. Chem. 258:2508-2513(1983) [PubMed] [Europe PMC] [Abstract]

"Tangier disease: defective recombination of a specific Tangier apolipoprotein A-I isoform (pro-apo A-I) with high density lipoproteins."
Proc. Natl. Acad. Sci. U.S.A. 80:6081-6085(1983) [PubMed] [Europe PMC] [Abstract]

"Apolipoprotein A-IGiessen (Pro143-->Arg). A mutant that is defective in activating lecithin:cholesterol acyltransferase."
Eur. J. Biochem. 144:325-331(1984) [PubMed] [Europe PMC] [Abstract]

"Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted."
J. Biol. Chem. 259:10063-10070(1984) [PubMed] [Europe PMC] [Abstract]

"Variant apolipoprotein AI as a major constituent of a human hereditary amyloid."
Biochem. Biophys. Res. Commun. 156:762-768(1988) [PubMed] [Europe PMC] [Abstract]

"A mutation in apolipoprotein A-I in the Iowa type of familial amyloidotic polyneuropathy."
Genomics 8:318-323(1990) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of human apolipoprotein A-I Fukuoka (110 Glu-->Lys). A novel apolipoprotein variant."
Biochim. Biophys. Acta 1043:169-176(1990) [PubMed] [Europe PMC] [Abstract]

"Apolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosis."
Proc. Natl. Acad. Sci. U.S.A. 89:7389-7393(1992) [PubMed] [Europe PMC] [Abstract]

"Apolipoprotein A1 Baltimore (Arg-10-->Leu), a new ApoA1 variant."
Hum. Genet. 84:439-445(1990) [PubMed] [Europe PMC] [Abstract]

"Apolipoprotein A-I variants. Naturally occurring substitutions of proline residues affect plasma concentration of apolipoprotein A-I."
J. Clin. Invest. 84:1722-1730(1989) [PubMed] [Europe PMC] [Abstract]

"Structural analysis of human apolipoprotein A-I variants. Amino acid substitutions are nonrandomly distributed throughout the apolipoprotein A-I primary structure."
J. Biol. Chem. 265:8610-8617(1990) [PubMed] [Europe PMC] [Abstract]

"Characterization of two new human apolipoprotein A-I variants: apolipoprotein A-I Tsushima (Trp-108-->Arg) and A-I Hita (Ala-95-->Asp)."
Biochim. Biophys. Acta 1214:272-278(1994) [PubMed] [Europe PMC] [Abstract]

"Familial nephropathic systemic amyloidosis caused by apolipoprotein AI variant Arg26."
Q. J. Med. 87:149-154(1994) [PubMed] [Europe PMC] [Abstract]

"A novel homozygous missense mutation in the apo A-I gene with apo A-I deficiency."
Arterioscler. Thromb. Vasc. Biol. 18:389-396(1998) [PubMed] [Europe PMC] [Abstract]

"Apo A-I Zaragoza(L144R): a novel mutation in the apolipoprotein A-I gene associated with familial hypoalphalipoproteinemia."
Hum. Mutat. 11:416-416(1998)

"Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors."
Hum. Mol. Genet. 12:2733-2743(2003) [PubMed] [Europe PMC] [Abstract]

"Quantitative detection of single amino acid polymorphisms by targeted proteomics."
J. Mol. Cell Biol. 3:309-315(2011) [PubMed] [Europe PMC] [Abstract]