Protein Kinase R (PKR)

PRKR; PRK-R; EIF2AK2; EIF2AK1; Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2; Interferon-induced, double-stranded RNA-activated protein kinase; P1/eIF-2A kinase

SPN	W289
HGNC	9437
MGI	1353449
PubMed	17969452
RGD	3402
UniProt	P19525
Wiki	PKR

PKR is activated by double-stranded RNA (dsRNA), the synthesis of which is caused virally. PKR can also be activated by the protein PACT or by heparin. PKR contains an N-terminal dsRNA binding domain (dsRBD) and a C-terminal kinase domain, that gives it pro-apoptotic (cell-killing) functions. The dsRBD consists of two tandem copies of a conserved double stranded RNA binding motif, dsRBM1 and dsRBM2. PKR is induced by interferon in a latent state. Binding to dsRNA is believed to activate PKR by inducing dimerization and subsequent autophosphorylation reactions. In situations of viral infection, the dsRNA created by viral replication and gene expression binds to the N-terminal domain, activating the protein and causing apoptosis of the cell to prevent further viral spread.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	W289Hu01	Recombinant Protein Kinase R (PKR)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protein Kinase R (PKR)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protein Kinase R (PKR)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry;ICC/IF
Assay Kits	KEW289Hu	ELISA Kit for Protein Kinase R (PKR)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protein Kinase R (PKR)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	W289Mu01	Recombinant Protein Kinase R (PKR)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protein Kinase R (PKR)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IP.
	PW289Mu01	Polyclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protein Kinase R (PKR)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protein Kinase R (PKR)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protein Kinase R (PKR)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protein Kinase R (PKR)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protein Kinase R (PKR)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IP.
	PW289Ra01	Polyclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protein Kinase R (PKR)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protein Kinase R (PKR)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protein Kinase R (PKR)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protein Kinase R (PKR)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protein Kinase R (PKR)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protein Kinase R (PKR)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protein Kinase R (PKR)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protein Kinase R (PKR)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protein Kinase R (PKR)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protein Kinase R (PKR)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protein Kinase R (PKR)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protein Kinase R (PKR)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protein Kinase R (PKR)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protein Kinase R (PKR)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protein Kinase R (PKR)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protein Kinase R (PKR)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protein Kinase R (PKR)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protein Kinase R (PKR)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protein Kinase R (PKR)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protein Kinase R (PKR)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protein Kinase R (PKR)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protein Kinase R (PKR)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protein Kinase R (PKR)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protein Kinase R (PKR)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protein Kinase R (PKR)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protein Kinase R (PKR)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protein Kinase R (PKR)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protein Kinase R (PKR)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protein Kinase R (PKR)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protein Kinase R (PKR)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protein Kinase R (PKR)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protein Kinase R (PKR)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protein Kinase R (PKR)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protein Kinase R (PKR)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protein Kinase R (PKR)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protein Kinase R (PKR)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protein Kinase R (PKR)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protein Kinase R (PKR)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protein Kinase R (PKR)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protein Kinase R (PKR)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protein Kinase R (PKR)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protein Kinase R (PKR)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protein Kinase R (PKR)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protein Kinase R (PKR)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protein Kinase R (PKR)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protein Kinase R (PKR)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protein Kinase R (PKR)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protein Kinase R (PKR)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protein Kinase R (PKR)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protein Kinase R (PKR)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protein Kinase R (PKR)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protein Kinase R (PKR)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protein Kinase R (PKR)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protein Kinase R (PKR)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protein Kinase R (PKR)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protein Kinase R (PKR)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protein Kinase R (PKR)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protein Kinase R (PKR)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protein Kinase R (PKR)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protein Kinase R (PKR)	CLIA assay for Antigen Detection

Reference

"Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon."
Cell 62:379-390(1990) [PubMed] [Europe PMC] [Abstract]

"Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2 alpha protein kinase from human cells."
Virology 188:33-46(1992) [PubMed] [Europe PMC] [Abstract]

"Mechanism of interferon action sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones."
Gene 178:191-193(1996) [PubMed] [Europe PMC] [Abstract]

"Structural organization of the human gene (PKR) encoding an interferon-inducible RNA-dependent protein kinase (PKR) and differences from its mouse homolog."
Genomics 36:197-201(1996) [PubMed] [Europe PMC] [Abstract]

"Genomic features of human PKR: alternative splicing and a polymorphic CGG repeat in the 5'-untranslated region."
J. Interferon Cytokine Res. 18:609-616(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]