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Plasminogen Activator, Tissue (tPA)

PLAT; T-PA; t-plasminogen activator; Alteplase; Reteplase

Tissue plasminogen activator is a protein involved in the breakdown of blood clots. Specifically, it is a serine protease (EC 3.4.21.68) found on endothelial cells, the cells that line the blood vessels. As an enzyme, it catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for clot breakdown. Because it works on the clotting system, tPA is used in clinical medicine to treat only embolic or thrombolytic stroke. Use is contraindicated in hemorrhagic stroke and head trauma.The classic role of tPA is in the clotting system. Specifically, tPA catalyzes the conversion of plasminogen into plasmin. It does so by cleaving the single-chained plasminogen into two chains. These two chains are linked by a disulfide bond and the resulting molecule is called plasmin.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W285Hu01 Recombinant Plasminogen Activator, Tissue (tPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Plasminogen Activator, Tissue (tPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IP.
PW285Hu02 Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry;ICC/IF
Assay Kits KEW285Hu ELISA Kit for Plasminogen Activator, Tissue (tPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Plasminogen Activator, Tissue (tPA) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W285Mu01 Recombinant Plasminogen Activator, Tissue (tPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Plasminogen Activator, Tissue (tPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IP.
PW285Mu02 Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IF.
LW285Mu71 Biotin Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry;ICC/IF
Assay Kits KEW285Mu ELISA Kit for Plasminogen Activator, Tissue (tPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Plasminogen Activator, Tissue (tPA) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W285Ra01 Recombinant Plasminogen Activator, Tissue (tPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Plasminogen Activator, Tissue (tPA) Bioactivity
Antibodies MW285Ra21 Monoclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry;ICC/IF
Assay Kits KEW285Ra ELISA Kit for Plasminogen Activator, Tissue (tPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Plasminogen Activator, Tissue (tPA) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Plasminogen Activator, Tissue (tPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Plasminogen Activator, Tissue (tPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Plasminogen Activator, Tissue (tPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Plasminogen Activator, Tissue (tPA) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W285Po01 Recombinant Plasminogen Activator, Tissue (tPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Plasminogen Activator, Tissue (tPA) Bioactivity
Antibodies MW285Po21 Monoclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry;ICC/IF
Assay Kits KEW285Po ELISA Kit for Plasminogen Activator, Tissue (tPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Plasminogen Activator, Tissue (tPA) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Plasminogen Activator, Tissue (tPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Plasminogen Activator, Tissue (tPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Plasminogen Activator, Tissue (tPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Plasminogen Activator, Tissue (tPA) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Plasminogen Activator, Tissue (tPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Plasminogen Activator, Tissue (tPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Plasminogen Activator, Tissue (tPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Plasminogen Activator, Tissue (tPA) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Plasminogen Activator, Tissue (tPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Plasminogen Activator, Tissue (tPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Plasminogen Activator, Tissue (tPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Plasminogen Activator, Tissue (tPA) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Plasminogen Activator, Tissue (tPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Plasminogen Activator, Tissue (tPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Plasminogen Activator, Tissue (tPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Plasminogen Activator, Tissue (tPA) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Plasminogen Activator, Tissue (tPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Plasminogen Activator, Tissue (tPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Plasminogen Activator, Tissue (tPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Plasminogen Activator, Tissue (tPA) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Plasminogen Activator, Tissue (tPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Plasminogen Activator, Tissue (tPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Plasminogen Activator, Tissue (tPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Plasminogen Activator, Tissue (tPA) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Plasminogen Activator, Tissue (tPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Plasminogen Activator, Tissue (tPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Plasminogen Activator, Tissue (tPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Plasminogen Activator, Tissue (tPA) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Plasminogen Activator, Tissue (tPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Plasminogen Activator, Tissue (tPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Plasminogen Activator, Tissue (tPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Plasminogen Activator, Tissue (tPA) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Plasminogen Activator, Tissue (tPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Plasminogen Activator, Tissue (tPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Plasminogen Activator, Tissue (tPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Plasminogen Activator, Tissue (tPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Plasminogen Activator, Tissue (tPA) CLIA assay for Antigen Detection

Reference

"Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli."
Nature 301:214-221(1983) [PubMed] [Europe PMC] [Abstract]

"The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains."
Proc. Natl. Acad. Sci. U.S.A. 81:5355-5359(1984) [PubMed] [Europe PMC] [Abstract]

"The human tissue plasminogen activator gene."
J. Biol. Chem. 261:6972-6985(1986) [PubMed] [Europe PMC] [Abstract]

"Cloning of cDNA coding for human tissue-type plasminogen activator and its expression in Escherichia coli."
Mol. Biol. Med. 3:279-292(1986) [PubMed] [Europe PMC] [Abstract]

"Expression of human uterine tissue-type plasminogen activator in mouse cells using BPV vectors."
DNA 6:461-472(1987) [PubMed] [Europe PMC] [Abstract]

"Nucleotide sequence of the tissue-type plasminogen activator cDNA from human fetal lung cells."
Nucleic Acids Res. 16:5695-5695(1988) [PubMed] [Europe PMC] [Abstract]

"Variant tissue-type plasminogen activator (PLAT) cDNA obtained from human endothelial cells."
Nucleic Acids Res. 18:1086-1086(1990) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of the human tissue-type plasminogen activator structural gene including its 5' flanking region."
J. Biol. Chem. 260:11223-11230(1985) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of tissue plasminogen activator secreted by human embryonic lung diploid fibroblasts, IMR-90 cells."
Agric. Biol. Chem. 55:1225-1232(1991) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of a melanoma cell plasminogen activator."
Eur. J. Biochem. 132:681-686(1983) [PubMed] [Europe PMC] [Abstract]

"Tissue plasminogen activator: peptide analyses confirm an indirectly derived amino acid sequence, identify the active site serine residue, establish glycosylation sites, and localize variant differences."
Biochemistry 23:3701-3707(1984) [PubMed] [Europe PMC] [Abstract]

"Isolation of cDNA sequences coding for a part of human tissue plasminogen activator."
Proc. Natl. Acad. Sci. U.S.A. 80:349-352(1983) [PubMed] [Europe PMC] [Abstract]