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Leucine Aminopeptidase (LAP)

LAPEP, LAP3; PEPS; Peptidase S; Leucyl Aminopeptidase; Cytosol aminopeptidase; Proline aminopeptidase; Prolyl aminopeptidase

Leucine aminopeptidase (LAP) is an exopeptidase hydrolyzing the peptide bond adjacent to a free amino group. LAP is extensively used in the sequence analysis of proteins and peptides. .The enzyme liberates amino acids from the N-terminal end of a number of proteins and polypeptides. It is called leucine aminopeptidase because it reacts most rapidly with leucine compounds. Many aliphatic amides are also hydrolyzed as well as thiolesters.LAP consists of four subunits each having one atom of zinc.

PEPS levels did not differ from controls in any. This experience permitted exclusion mapping of PEPS to 4p11-4q13; combined with previously reported data, the assignment becomes 4p11-4q12.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW274Hu01 Recombinant Leucine Aminopeptidase (LAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW274Hu01 Monoclonal Antibody to Leucine Aminopeptidase (LAP) WB; IHC; ICC; IP.
PAW274Hu01 Polyclonal Antibody to Leucine Aminopeptidase (LAP) WB; IHC; ICC; IF.
Assay Kits CLW274Hu01 CLIA Kit for Leucine Aminopeptidase (LAP) CLIA assay for Antigen Detection
ELW274Hu01 ELISA Kit for Leucine Aminopeptidase (LAP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW274Mu01 Recombinant Leucine Aminopeptidase (LAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW274Mu01 Monoclonal Antibody to Leucine Aminopeptidase (LAP) WB; IHC; ICC; IP.
PAW274Mu01 Polyclonal Antibody to Leucine Aminopeptidase (LAP) WB; IHC; ICC; IF.
Assay Kits CLW274Mu01 CLIA Kit for Leucine Aminopeptidase (LAP) CLIA assay for Antigen Detection
ELW274Mu01 ELISA Kit for Leucine Aminopeptidase (LAP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW274Ra01 Recombinant Leucine Aminopeptidase (LAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW274Ra01 Monoclonal Antibody to Leucine Aminopeptidase (LAP) WB; IHC; ICC; IP.
PAW274Ra01 Polyclonal Antibody to Leucine Aminopeptidase (LAP) WB; IHC; ICC; IF.
Assay Kits CLW274Ra01 CLIA Kit for Leucine Aminopeptidase (LAP) CLIA assay for Antigen Detection
ELW274Ra01 ELISA Kit for Leucine Aminopeptidase (LAP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW274Ca01 Recombinant Leucine Aminopeptidase (LAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW274Ca01 Monoclonal Antibody to Leucine Aminopeptidase (LAP) WB; IHC; ICC; IP.
PAW274Ca01 Polyclonal Antibody to Leucine Aminopeptidase (LAP) WB; IHC; ICC; IF.
Assay Kits CLW274Ca01 CLIA Kit for Leucine Aminopeptidase (LAP) CLIA assay for Antigen Detection
ELW274Ca01 ELISA Kit for Leucine Aminopeptidase (LAP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW274Po01 Recombinant Leucine Aminopeptidase (LAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW274Po01 Monoclonal Antibody to Leucine Aminopeptidase (LAP) WB; IHC; ICC; IP.
PAW274Po01 Polyclonal Antibody to Leucine Aminopeptidase (LAP) WB; IHC; ICC; IF.
Assay Kits CLW274Po01 CLIA Kit for Leucine Aminopeptidase (LAP) CLIA assay for Antigen Detection
ELW274Po01 ELISA Kit for Leucine Aminopeptidase (LAP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW274Bo01 Recombinant Leucine Aminopeptidase (LAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW274Bo01 Monoclonal Antibody to Leucine Aminopeptidase (LAP) WB; IHC; ICC; IP.
PAW274Bo01 Polyclonal Antibody to Leucine Aminopeptidase (LAP) WB; IHC; ICC; IF.
Assay Kits CLW274Bo01 CLIA Kit for Leucine Aminopeptidase (LAP) CLIA assay for Antigen Detection
ELW274Bo01 ELISA Kit for Leucine Aminopeptidase (LAP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW274Rb01 Recombinant Leucine Aminopeptidase (LAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW274Rb01 Monoclonal Antibody to Leucine Aminopeptidase (LAP) WB; IHC; ICC; IP.
PAW274Rb01 Polyclonal Antibody to Leucine Aminopeptidase (LAP) WB; IHC; ICC; IF.
Assay Kits CLW274Rb01 CLIA Kit for Leucine Aminopeptidase (LAP) CLIA assay for Antigen Detection
ELW274Rb01 ELISA Kit for Leucine Aminopeptidase (LAP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW274Mo01 Recombinant Leucine Aminopeptidase (LAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW274Mo01 Monoclonal Antibody to Leucine Aminopeptidase (LAP) WB; IHC; ICC; IP.
PAW274Mo01 Polyclonal Antibody to Leucine Aminopeptidase (LAP) WB; IHC; ICC; IF.
Assay Kits CLW274Mo01 CLIA Kit for Leucine Aminopeptidase (LAP) CLIA assay for Antigen Detection
ELW274Mo01 ELISA Kit for Leucine Aminopeptidase (LAP) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structural and immunological evidence for the identity of prolyl aminopeptidase with leucyl aminopeptidase."
Biochem. Biophys. Res. Commun. 178:1459-1464(1991) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]