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Enolase, Neuron Specific (NSE)

ENO2; Enolase 2; Gamma Enolase; 2-phospho-D-glycerate hydro-lyase; Neural enolase

The glycolytic enzyme enolase (2-phosph-D-glycerate hydrolyase) exists as several dimeric isoenzymes (aa, ab, ag and gg) composed of three distinct subunits, a, b, and g. Three isoenzymes are found in rat brain: aa, ag and gg. The ag and gg-enolase isoenzymes are also known as neuron­-specific enolase (NSE) as these isoenzymes initially were detected in neurons and neuronendocrine cells. The NSE levels are low in health and benign subjects. Elevated levels are commonly found in patients with malignant tumors with neuronendocrine differentiation, especially small cell lung cancer and neuroblasloma. NSE are reported to be useful diagnostic marker for lung cancer, neuroblastoma, melanoma, seminoma and in injury of central nervous system.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W273Hu01 Recombinant Enolase, Neuron Specific (NSE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Enolase, Neuron Specific (NSE) Bioactivity
Antibodies MW273Hu21 Monoclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IP.
PW273Hu02 Polyclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IF.
LW273Hu71 Biotin Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry;ICC/IF
Assay Kits KEW273Hu ELISA Kit for Enolase, Neuron Specific (NSE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Enolase, Neuron Specific (NSE) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W273Mu01 Recombinant Enolase, Neuron Specific (NSE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Enolase, Neuron Specific (NSE) Bioactivity
Antibodies NONE Monoclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IP.
PW273Mu02 Polyclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IF.
LW273Mu71 Biotin Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry
LW273Mu81 FITC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry;ICC/IF
Assay Kits KEW273Mu ELISA Kit for Enolase, Neuron Specific (NSE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Enolase, Neuron Specific (NSE) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W273Ra01 Recombinant Enolase, Neuron Specific (NSE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Enolase, Neuron Specific (NSE) Bioactivity
Antibodies MW273Ra21 Monoclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IF.
LW273Ra71 Biotin Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry
LW273Ra81 FITC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry;ICC/IF
Assay Kits KEW273Ra ELISA Kit for Enolase, Neuron Specific (NSE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Enolase, Neuron Specific (NSE) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Enolase, Neuron Specific (NSE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Enolase, Neuron Specific (NSE) Bioactivity
Antibodies NONE Monoclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Enolase, Neuron Specific (NSE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Enolase, Neuron Specific (NSE) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Enolase, Neuron Specific (NSE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Enolase, Neuron Specific (NSE) Bioactivity
Antibodies NONE Monoclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Enolase, Neuron Specific (NSE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Enolase, Neuron Specific (NSE) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Enolase, Neuron Specific (NSE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Enolase, Neuron Specific (NSE) Bioactivity
Antibodies NONE Monoclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Enolase, Neuron Specific (NSE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Enolase, Neuron Specific (NSE) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Enolase, Neuron Specific (NSE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Enolase, Neuron Specific (NSE) Bioactivity
Antibodies NONE Monoclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Enolase, Neuron Specific (NSE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Enolase, Neuron Specific (NSE) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Enolase, Neuron Specific (NSE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Enolase, Neuron Specific (NSE) Bioactivity
Antibodies NONE Monoclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Enolase, Neuron Specific (NSE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Enolase, Neuron Specific (NSE) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Enolase, Neuron Specific (NSE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Enolase, Neuron Specific (NSE) Bioactivity
Antibodies NONE Monoclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Enolase, Neuron Specific (NSE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Enolase, Neuron Specific (NSE) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W273Rb01 Recombinant Enolase, Neuron Specific (NSE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Enolase, Neuron Specific (NSE) Bioactivity
Antibodies MW273Rb21 Monoclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IP.
PW273Rb51 Polyclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry;ICC/IF
Assay Kits KEW273Rb ELISA Kit for Enolase, Neuron Specific (NSE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Enolase, Neuron Specific (NSE) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Enolase, Neuron Specific (NSE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Enolase, Neuron Specific (NSE) Bioactivity
Antibodies NONE Monoclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Enolase, Neuron Specific (NSE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Enolase, Neuron Specific (NSE) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Enolase, Neuron Specific (NSE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Enolase, Neuron Specific (NSE) Bioactivity
Antibodies NONE Monoclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Enolase, Neuron Specific (NSE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Enolase, Neuron Specific (NSE) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Enolase, Neuron Specific (NSE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Enolase, Neuron Specific (NSE) Bioactivity
Antibodies NONE Monoclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Enolase, Neuron Specific (NSE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Enolase, Neuron Specific (NSE) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Enolase, Neuron Specific (NSE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Enolase, Neuron Specific (NSE) Bioactivity
Antibodies NONE Monoclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Enolase, Neuron Specific (NSE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Enolase, Neuron Specific (NSE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Enolase, Neuron Specific (NSE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Enolase, Neuron Specific (NSE) CLIA assay for Antigen Detection

Reference

"Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE)."
Eur. J. Biochem. 178:413-417(1988) [PubMed] [Europe PMC] [Abstract]

"Human gamma enolase: isolation of a cDNA clone and expression in normal and tumor tissues of human origin."
J. Neurosci. Res. 19:450-456(1988) [PubMed] [Europe PMC] [Abstract]

"Cloning, expression and sequence homologies of cDNA for human gamma enolase."
Gene 79:355-360(1989) [PubMed] [Europe PMC] [Abstract]

"Complete structure of the human gene encoding neuron-specific enolase."
Genomics 10:157-165(1991) [PubMed] [Europe PMC] [Abstract]

"Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination."
Genome Res. 7:268-280(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

, Submitted (DEC-2008) to UniProtKB

"Sequence conservation in the 3'-untranslated regions of neurone-specific enolase, lymphokine and protooncogene mRNAs."
FEBS Lett. 222:139-143(1987) [PubMed] [Europe PMC] [Abstract]

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Expression, purification and the 1.8 angstroms resolution crystal structure of human neuron specific enolase."
J. Mol. Biol. 341:1015-1021(2004) [PubMed] [Europe PMC] [Abstract]