Myelin Basic Protein (MBP)
Myelin A1 protein; Myelin membrane encephalitogenic protein
Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the central nervous system (CNS). Myelin Basic Protein (MBP) is the major constituent of the CNS myelin synthesized by oligodendrocytes and Schwann cells. MBP, PLP (proteolipid proteins) and MOG (myelin oligodendrocyte glycoprotein) are potential primary encephalitogenic target antigens in multiple sclerosis.MBP was initially sequenced in 1979 after isolation from myelin membranes. Since that time, knockout mice deficient in MBP have been developed which showed decreased amounts of CNS myelination and a progressive disorder characterized by tremors, seizures, and early death. The gene for MBP is on chromosome 18; the protein localizes to the CNS and to various cells of the hematopoietic system.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW271Hu01 | Recombinant Myelin Basic Protein (MBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW271Hu01 | Monoclonal Antibody to Myelin Basic Protein (MBP) | WB; IHC; ICC; IP. |
| PAW271Hu01 | Polyclonal Antibody to Myelin Basic Protein (MBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW271Hu01 | CLIA Kit for Myelin Basic Protein (MBP) | CLIA assay for Antigen Detection |
| ELW271Hu01 | ELISA Kit for Myelin Basic Protein (MBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW271Mu01 | Recombinant Myelin Basic Protein (MBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW271Mu01 | Monoclonal Antibody to Myelin Basic Protein (MBP) | WB; IHC; ICC; IP. |
| PAW271Mu01 | Polyclonal Antibody to Myelin Basic Protein (MBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW271Mu01 | CLIA Kit for Myelin Basic Protein (MBP) | CLIA assay for Antigen Detection |
| ELW271Mu01 | ELISA Kit for Myelin Basic Protein (MBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW271Ra01 | Recombinant Myelin Basic Protein (MBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW271Ra01 | Monoclonal Antibody to Myelin Basic Protein (MBP) | WB; IHC; ICC; IP. |
| PAW271Ra01 | Polyclonal Antibody to Myelin Basic Protein (MBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW271Ra01 | CLIA Kit for Myelin Basic Protein (MBP) | CLIA assay for Antigen Detection |
| ELW271Ra01 | ELISA Kit for Myelin Basic Protein (MBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW271Ca01 | Recombinant Myelin Basic Protein (MBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW271Ca01 | Monoclonal Antibody to Myelin Basic Protein (MBP) | WB; IHC; ICC; IP. |
| PAW271Ca01 | Polyclonal Antibody to Myelin Basic Protein (MBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW271Ca01 | CLIA Kit for Myelin Basic Protein (MBP) | CLIA assay for Antigen Detection |
| ELW271Ca01 | ELISA Kit for Myelin Basic Protein (MBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW271Po01 | Recombinant Myelin Basic Protein (MBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW271Po01 | Monoclonal Antibody to Myelin Basic Protein (MBP) | WB; IHC; ICC; IP. |
| PAW271Po01 | Polyclonal Antibody to Myelin Basic Protein (MBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW271Po01 | CLIA Kit for Myelin Basic Protein (MBP) | CLIA assay for Antigen Detection |
| ELW271Po01 | ELISA Kit for Myelin Basic Protein (MBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW271Bo01 | Recombinant Myelin Basic Protein (MBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW271Bo01 | Monoclonal Antibody to Myelin Basic Protein (MBP) | WB; IHC; ICC; IP. |
| PAW271Bo01 | Polyclonal Antibody to Myelin Basic Protein (MBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW271Bo01 | CLIA Kit for Myelin Basic Protein (MBP) | CLIA assay for Antigen Detection |
| ELW271Bo01 | ELISA Kit for Myelin Basic Protein (MBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW271Rb01 | Recombinant Myelin Basic Protein (MBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW271Rb01 | Monoclonal Antibody to Myelin Basic Protein (MBP) | WB; IHC; ICC; IP. |
| PAW271Rb01 | Polyclonal Antibody to Myelin Basic Protein (MBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW271Rb01 | CLIA Kit for Myelin Basic Protein (MBP) | CLIA assay for Antigen Detection |
| ELW271Rb01 | ELISA Kit for Myelin Basic Protein (MBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW271Mo01 | Recombinant Myelin Basic Protein (MBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW271Mo01 | Monoclonal Antibody to Myelin Basic Protein (MBP) | WB; IHC; ICC; IP. |
| PAW271Mo01 | Polyclonal Antibody to Myelin Basic Protein (MBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW271Mo01 | CLIA Kit for Myelin Basic Protein (MBP) | CLIA assay for Antigen Detection |
| ELW271Mo01 | ELISA Kit for Myelin Basic Protein (MBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Amino acid sequence of the encephalitogenic basic protein from human myelin."
Biochem. J. 123:57-67(1971) [PubMed] [Europe PMC] [Abstract]
"Isolation and characterization of a cDNA coding for a novel human 17.3K myelin basic protein (MBP) variant."
J. Neurosci. Res. 16:227-238(1986) [PubMed] [Europe PMC] [Abstract]
"Identification of three forms of human myelin basic protein by cDNA cloning."
Proc. Natl. Acad. Sci. U.S.A. 83:4962-4966(1986) [PubMed] [Europe PMC] [Abstract]
"Evidence for the expression of four myelin basic protein variants in the developing human spinal cord through cDNA cloning."
J. Neurosci. Res. 17:321-328(1987) [PubMed] [Europe PMC] [Abstract]
"The organization of the human myelin basic protein gene. Comparison with the mouse gene."
Biol. Chem. Hoppe-Seyler 370:503-510(1989) [PubMed] [Europe PMC] [Abstract]
"The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems."
Proc. Natl. Acad. Sci. U.S.A. 90:10695-10699(1993) [PubMed] [Europe PMC] [Abstract]
"Purification of immunologically active recombinant 21.5 kDa isoform of human myelin basic protein."
Mol. Immunol. 32:1131-1141(1995) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 18."
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Repetitive DNA (TGGA)n 5' to the human myelin basic protein gene: a new form of oligonucleotide repetitive sequence showing length polymorphism."
Genomics 6:16-22(1990) [PubMed] [Europe PMC] [Abstract]
"Analysis of the primary sequence of human myelin basic protein peptides 1-44 and 90-170 by fast atom bombardment mass spectrometry."
J. Neurochem. 47:614-616(1986) [PubMed] [Europe PMC] [Abstract]
"The isolation, characterization, and lipid-aggregating properties of a citrulline containing myelin basic protein."
J. Biol. Chem. 264:5121-5127(1989) [PubMed] [Europe PMC] [Abstract]
"The isolation and characterization of four myelin basic proteins from the unbound fraction during CM52 chromatography."
Arch. Biochem. Biophys. 322:174-182(1995) [PubMed] [Europe PMC] [Abstract]
"Amino acid sequence of human myelin basic protein peptide 45-89 as determined by mass spectrometry."
J. Biol. Chem. 259:5028-5031(1984) [PubMed] [Europe PMC] [Abstract]
"Encephalitogenic fragment of myelin basic protein. Amino acid sequence of bovine, rabbit, guinea pig, monkey, and human fragments."
J. Biol. Chem. 246:4630-4640(1971)
"Immunologic properties of the main encephalitogenic peptide from the basic protein of human myelin."
J. Immunol. 105:1223-1230(1970) [PubMed] [Europe PMC] [Abstract]
"Leukocyte gelatinase B cleavage releases encephalitogens from human myelin basic protein."
Biochem. Biophys. Res. Commun. 192:1175-1181(1993) [PubMed] [Europe PMC] [Abstract]
"Isolation and partial characterization of methylated arginines from the encephalitogenic basic protein of myelin."
Biochem. J. 123:69-74(1971) [PubMed] [Europe PMC] [Abstract]
"Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6."
J. Biol. Chem. 273:1741-1748(1998) [PubMed] [Europe PMC] [Abstract]
"Specific Ser-Pro phosphorylation by the RNA-recognition motif containing kinase KIS."
Eur. J. Biochem. 267:4456-4464(2000) [PubMed] [Europe PMC] [Abstract]
"PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the JNK MAPK pathway and regulates actin cytoskeletal organisation."
J. Biol. Chem. 275:4311-4322(2000) [PubMed] [Europe PMC] [Abstract]
"Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells."
Mol. Cell 20:673-685(2005) [PubMed] [Europe PMC] [Abstract]
"The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines."
FEBS J. 273:2487-2504(2006) [PubMed] [Europe PMC] [Abstract]
"Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK-and caspase-dependent nuclear localization is a requirement for membrane blebbing."
J. Biol. Chem. 282:6484-6493(2007) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"The 21.5-kDa isoform of myelin basic protein has a non-traditional PY-nuclear-localization signal."
Biochem. Biophys. Res. Commun. 422:670-675(2012) [PubMed] [Europe PMC] [Abstract]
"Identification and Characterization of citrulline-modified brain proteins by combining HCD and CID fragmentation."
Proteomics 13:2682-2691(2013) [PubMed] [Europe PMC] [Abstract]
"Conformation of a tetradecapeptide epitope of myelin basic protein."
Eur. J. Biochem. 231:659-666(1995) [PubMed] [Europe PMC] [Abstract]
"Three-dimensional structure of myelin basic protein. II. Molecular modeling and considerations of predicted structures in multiple sclerosis."
J. Biol. Chem. 272:4269-4275(1997) [PubMed] [Europe PMC] [Abstract]
"Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins."
J. Mol. Biol. 304:177-188(2000) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II."
Immunity 14:93-104(2001) [PubMed] [Europe PMC] [Abstract]
"Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule."
EMBO J. 24:2968-2979(2005) [PubMed] [Europe PMC] [Abstract]