Immunoglobulin E (IgE)

IGHE; Immunoglobulin Heavy Constant Epsilon; Ig epsilon chain C region

SPN	W265
HGNC	5522
MGI	96449
PubMed	12949496
UniProt	P01854
Wiki	IgE

Immunoglobulin E (IgE) is a class of antibody produced in the lungs, skin, and mucous membranes that has only been found in mammals. It plays an important role in allergy, and is especially associated with type 1 hypersensitivity. IgE has also been implicated in immune system responses to most parasitic worms like Schistosoma mansoni, Trichinella spiralis, and Fasciola hepatica, and may be important during immune defense against certain protozoan parasites such as Plasmodium falciparum. The antigen-specific IgE interacts with mast cells and eosinophils, triggers the release of histamine, leukotrienes and other substances that lead to the itching, sneezing and congestion of allergies - and the life threatening respiratory distress of asthma and anaphylactic shock.

Reference

"Duplication and deletion in the human immunoglobulin epsilon genes."
Cell 29:691-699(1982) [PubMed] [Europe PMC] [Abstract]

"The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes."
EMBO J. 1:655-660(1982) [PubMed] [Europe PMC] [Abstract]

"Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns."
EMBO J. 1:1539-1544(1982) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA."
Nucleic Acids Res. 11:719-726(1983) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

(In) Bach M.K. (eds.);Immediate hypersensitivity: modern concepts and developments, pp.1-36, Marcel Dekker, New York (1978)

"Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line."
Proc. Natl. Acad. Sci. U.S.A. 79:6661-6665(1982) [PubMed] [Europe PMC] [Abstract]

"A model of the Fc of immunoglobulin E."
Mol. Immunol. 23:1063-1075(1986) [PubMed] [Europe PMC] [Abstract]