Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5)
NOX5A; NOX5B; NOX5-A; NOX5-B; NADPH Oxidase,EF-Hand Calcium Binding Domain 5
NOX5 is distantly related to the gp91-phox subunit of the phagocyte NADPH oxidase with conserved regions crucial for electron transport (NADPH, FAD, and heme binding sites). However, NOX5 has a unique N-terminal extension that contains 3 EF-hand motifs.
Banfi et al. (2001) demonstrated 2 NOX5 isoforms of 737 and 719 amino acids, designated NOX5A and NOX5B, respectively. Northern blot analysis demonstrated restricted expression of an approximately 2.7-kb NOX5A transcript in spleen and an approximately 2.9-kb NOX5B transcript in testis. In situ hybridization localized NOX5 in pachytene spermatocytes of testis and in B- and T-lymphocytic-rich areas of spleen and lymph nodes.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW255Hu01 | Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW255Hu01 | Monoclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | WB; IHC; ICC; IP. |
| PAW255Hu01 | Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW255Hu01 | CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | CLIA assay for Antigen Detection |
| ELW255Hu01 | ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW255Mu01 | Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW255Mu01 | Monoclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | WB; IHC; ICC; IP. |
| PAW255Mu01 | Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW255Mu01 | CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | CLIA assay for Antigen Detection |
| ELW255Mu01 | ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW255Ra01 | Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW255Ra01 | Monoclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | WB; IHC; ICC; IP. |
| PAW255Ra01 | Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW255Ra01 | CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | CLIA assay for Antigen Detection |
| ELW255Ra01 | ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW255Ca01 | Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW255Ca01 | Monoclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | WB; IHC; ICC; IP. |
| PAW255Ca01 | Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW255Ca01 | CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | CLIA assay for Antigen Detection |
| ELW255Ca01 | ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW255Po01 | Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW255Po01 | Monoclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | WB; IHC; ICC; IP. |
| PAW255Po01 | Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW255Po01 | CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | CLIA assay for Antigen Detection |
| ELW255Po01 | ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW255Bo01 | Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW255Bo01 | Monoclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | WB; IHC; ICC; IP. |
| PAW255Bo01 | Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW255Bo01 | CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | CLIA assay for Antigen Detection |
| ELW255Bo01 | ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW255Rb01 | Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW255Rb01 | Monoclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | WB; IHC; ICC; IP. |
| PAW255Rb01 | Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW255Rb01 | CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | CLIA assay for Antigen Detection |
| ELW255Rb01 | ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW255Mo01 | Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW255Mo01 | Monoclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | WB; IHC; ICC; IP. |
| PAW255Mo01 | Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW255Mo01 | CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | CLIA assay for Antigen Detection |
| ELW255Mo01 | ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes."
J. Biol. Chem. 276:37594-37601(2001) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation."
J. Biol. Chem. 280:31859-31869(2005) [PubMed] [Europe PMC] [Abstract]
"Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5."
Gene 269:131-140(2001) [PubMed] [Europe PMC] [Abstract]
"NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells."
Am. J. Physiol. 285:C353-C369(2003) [PubMed] [Europe PMC] [Abstract]
"Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5)."
J. Biol. Chem. 279:18583-18591(2004) [PubMed] [Europe PMC] [Abstract]
"NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts."
Circ. Res. 97:900-907(2005) [PubMed] [Europe PMC] [Abstract]
"Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia."
J. Immunol. 175:8424-8430(2005) [PubMed] [Europe PMC] [Abstract]
"NOX5 variants are functionally active in endothelial cells."
Free Radic. Biol. Med. 42:446-459(2007) [PubMed] [Europe PMC] [Abstract]