Fatty Acid Binding Protein 2, Intestinal (FABP2)

FABPI; IFABP; I-FABP; Intestinal-type fatty acid-binding protein

SPN	W251
HGNC	3556
MGI	95478
PubMed	16718625
RGD	2591
UniProt	P12104
Wiki	FABP2

The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation.

Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance.

Reference

"The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships."
J. Biol. Chem. 262:16060-16071(1987) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility."
Clin. Biochem. 36:529-535(2003) [PubMed] [Europe PMC] [Abstract]

"Epidermal growth factor regulates fatty acid uptake and metabolism in Caco-2 cells."
Am. J. Physiol. 276:G606-G612(1999) [PubMed] [Europe PMC] [Abstract]

"Consequences of single-site mutations in the intestinal fatty acid binding protein."
Biochemistry 42:12192-12199(2003) [PubMed] [Europe PMC] [Abstract]

"Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit."
J. Biomol. NMR 9:213-228(1997) [PubMed] [Europe PMC] [Abstract]

"Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism."
Biochemistry 42:7339-7347(2003) [PubMed] [Europe PMC] [Abstract]

"An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance."
J. Clin. Invest. 95:1281-1287(1995) [PubMed] [Europe PMC] [Abstract]

"The association of Ala54Thr variant of intestinal fatty acid binding protein gene with general and regional adipose tissue depots."
Chin. Med. Sci. J. 14:46-51(1999) [PubMed] [Europe PMC] [Abstract]