Selectin, Platelet (SELP)

CD62P; P-Selectin; PSEL; GMP140; LECAM3; GRMP; GMRP; PADGEM; Leukocyte-endothelial cell adhesion molecule 3; Platelet activation dependent granule-external membrane

SPN	W241
HGNC	10721
MGI	98280
PubMed	18618353
RGD	3656
UniProt	P16109
Wiki	P-selectin

P-selectin is the largest of the known selectins at 140kDa. It contains nine consensus repeats (CR) and extends approximately 40 nm from the endothelial surface. P-selectin is expressed in a-granules of activated platelets and granules of endothelial cells. Within minutes of stimulation of the endothelial cells by inflammatory mediators such as histamine, thrombin, or phorbol esters, P-selectin is surface-expressed. Expression of P-selectin also occurs from the surgical trauma endured during preparation of the tissues for intravital microscopy. The expression is short-lived, reaching its peak after only ten minutes. Additional synthesis of P-selectin is brought about within two hours by cytokines such as interleukin-1 (IL-1) or tumor necrosis factor a (TNF-a).

Reference

"Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation."
Cell 56:1033-1044(1989) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"P-selectin is acylated with palmitic acid and stearic acid at cysteine 766 through a thioester linkage."
J. Biol. Chem. 268:11394-11400(1993) [PubMed] [Europe PMC] [Abstract]

"A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding."
Cell 83:323-331(1995) [PubMed] [Europe PMC] [Abstract]

"PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus."
Cell 83:333-343(1995) [PubMed] [Europe PMC] [Abstract]

"Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin."
J. Biol. Chem. 270:22677-22680(1995) [PubMed] [Europe PMC] [Abstract]

"A new member of the sorting nexin family interacts with the C-terminus of P-selectin."
Biochem. Biophys. Res. Commun. 281:1045-1050(2001) [PubMed] [Europe PMC] [Abstract]

"Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking."
J. Mol. Biol. 347:813-825(2005) [PubMed] [Europe PMC] [Abstract]

"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]

"Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins."
J. Immunol. 181:1480-1490(2008) [PubMed] [Europe PMC] [Abstract]

"Structure and function of the epidermal growth factor domain of P-selectin."
Biochemistry 35:13733-13744(1996) [PubMed] [Europe PMC] [Abstract]

"Knowledge-based model building of proteins: concepts and examples."
Protein Sci. 2:1798-1810(1993) [PubMed] [Europe PMC] [Abstract]

"Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1."
Cell 103:467-479(2000) [PubMed] [Europe PMC] [Abstract]

Erratum
Cell 105:971-971(2001)

"The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction."
Hum. Mol. Genet. 7:1277-1284(1998) [PubMed] [Europe PMC] [Abstract]

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 23:373-373(1999)

"Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis."
Hum. Mol. Genet. 13:389-396(2004) [PubMed] [Europe PMC] [Abstract]