Phospholipase A2 Activating Protein (PLAA)
PLAP; PLA2P; PLA2-P; DOA1
Phospholipase A2-activating protein (PLAP) is potentially important in regulating the inflammatory response through its activation of phospholipase A2, which catalyzes the release of arachidonic acid. By screening a human monocyte cDNA library with a mouse Plap cDNA, Chopra et al. (1999) isolated human PLAP cDNAs. The 738-amino acid human PLAP protein predicted by the cDNA sequence has a molecular mass of 80,826 kD; however, immunoblot analysis using antibodies against PLAP detected a 72- to 74-kD protein in human monocyte cell lysates. In mouse macrophages, an antisense Plap oligonucleotide blocked cholera toxin-induced arachidonic acid release, indicating a role for PLAP in the regulation of phospholipase A2 activation.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW234Hu01 | Recombinant Phospholipase A2 Activating Protein (PLAA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW234Hu01 | Monoclonal Antibody to Phospholipase A2 Activating Protein (PLAA) | WB; IHC; ICC; IP. |
| PAW234Hu01 | Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW234Hu01 | CLIA Kit for Phospholipase A2 Activating Protein (PLAA) | CLIA assay for Antigen Detection |
| ELW234Hu01 | ELISA Kit for Phospholipase A2 Activating Protein (PLAA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW234Mu01 | Recombinant Phospholipase A2 Activating Protein (PLAA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW234Mu01 | Monoclonal Antibody to Phospholipase A2 Activating Protein (PLAA) | WB; IHC; ICC; IP. |
| PAW234Mu01 | Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW234Mu01 | CLIA Kit for Phospholipase A2 Activating Protein (PLAA) | CLIA assay for Antigen Detection |
| ELW234Mu01 | ELISA Kit for Phospholipase A2 Activating Protein (PLAA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW234Ra01 | Recombinant Phospholipase A2 Activating Protein (PLAA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW234Ra01 | Monoclonal Antibody to Phospholipase A2 Activating Protein (PLAA) | WB; IHC; ICC; IP. |
| PAW234Ra01 | Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW234Ra01 | CLIA Kit for Phospholipase A2 Activating Protein (PLAA) | CLIA assay for Antigen Detection |
| ELW234Ra01 | ELISA Kit for Phospholipase A2 Activating Protein (PLAA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW234Ca01 | Recombinant Phospholipase A2 Activating Protein (PLAA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW234Ca01 | Monoclonal Antibody to Phospholipase A2 Activating Protein (PLAA) | WB; IHC; ICC; IP. |
| PAW234Ca01 | Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW234Ca01 | CLIA Kit for Phospholipase A2 Activating Protein (PLAA) | CLIA assay for Antigen Detection |
| ELW234Ca01 | ELISA Kit for Phospholipase A2 Activating Protein (PLAA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW234Po01 | Recombinant Phospholipase A2 Activating Protein (PLAA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW234Po01 | Monoclonal Antibody to Phospholipase A2 Activating Protein (PLAA) | WB; IHC; ICC; IP. |
| PAW234Po01 | Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW234Po01 | CLIA Kit for Phospholipase A2 Activating Protein (PLAA) | CLIA assay for Antigen Detection |
| ELW234Po01 | ELISA Kit for Phospholipase A2 Activating Protein (PLAA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW234Bo01 | Recombinant Phospholipase A2 Activating Protein (PLAA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW234Bo01 | Monoclonal Antibody to Phospholipase A2 Activating Protein (PLAA) | WB; IHC; ICC; IP. |
| PAW234Bo01 | Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW234Bo01 | CLIA Kit for Phospholipase A2 Activating Protein (PLAA) | CLIA assay for Antigen Detection |
| ELW234Bo01 | ELISA Kit for Phospholipase A2 Activating Protein (PLAA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW234Rb01 | Recombinant Phospholipase A2 Activating Protein (PLAA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW234Rb01 | Monoclonal Antibody to Phospholipase A2 Activating Protein (PLAA) | WB; IHC; ICC; IP. |
| PAW234Rb01 | Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW234Rb01 | CLIA Kit for Phospholipase A2 Activating Protein (PLAA) | CLIA assay for Antigen Detection |
| ELW234Rb01 | ELISA Kit for Phospholipase A2 Activating Protein (PLAA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW234Mo01 | Recombinant Phospholipase A2 Activating Protein (PLAA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW234Mo01 | Monoclonal Antibody to Phospholipase A2 Activating Protein (PLAA) | WB; IHC; ICC; IP. |
| PAW234Mo01 | Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW234Mo01 | CLIA Kit for Phospholipase A2 Activating Protein (PLAA) | CLIA assay for Antigen Detection |
| ELW234Mo01 | ELISA Kit for Phospholipase A2 Activating Protein (PLAA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
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Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Chromosomal localization of phospholipase A2 activating protein, an ets2 target gene, to 9p21."
Genomics 62:529-532(1999) [PubMed] [Europe PMC] [Abstract]
"Cloning of the human phospholipase A2 activating protein (hPLAP) gene on the chromosome 9p21 melanoma deleted region."
Gene 239:155-161(1999) [PubMed] [Europe PMC] [Abstract]
"Molecular characterization of cDNA for phospholipase A2-activating protein."
Biochim. Biophys. Acta 1444:125-130(1999) [PubMed] [Europe PMC] [Abstract]
"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Structural basis for ubiquitin recognition by a novel domain from human phospholipase A2-activating protein."
J. Biol. Chem. 284:19043-19052(2009) [PubMed] [Europe PMC] [Abstract]
"Structure and function of the PLAA/Ufd3-p97/Cdc48 complex."
J. Biol. Chem. 285:365-372(2010) [PubMed] [Europe PMC] [Abstract]