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Cyclin D1 (CCND1)

CCN-D1; BCL1; PRAD1; U21B31; G1/S-Specific Cyclin-D1; Parathyroid Adenomatosis 1; B-Cell CLL/Lymphoma 1; G1/S-Specific Cyclin D1; PRAD1 oncogene

Cyclin D1 belongs to the family of cyclin proteins which function as the regulatory subunits of cyclin/cyclin dependent kinase (Cdk) holoenzymes that regulate entry into and progression through the cell cycle. Cyclin D1 expression is induced upon stimulation by growth factors (e.g.EGF, IGF-I/II), amino acids, hormones, and oncogenes such as Ras, Src, ErbB2, and SV40 T antigen. Cdk4 and Cdk6 can partner with Cyclin D1 in early to mid-G1 phase to phosphorylate and inactivate the cell-cycle inhibitory function of the retinoblastoma protein (pRB) in cooperation with Cyclin E/Cdk2. Cyclin D1 is also known to modulate local chromatin structure and transcription of genes involved in proliferation and differentiation through CDK-independent association with histone acetylases (e.g. CBP, P/CAF) and deacetylases.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW225Hu01 Recombinant Cyclin D1 (CCND1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW225Hu01 Monoclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IP.
PAW225Hu01 Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IF.
Assay Kits CLW225Hu01 CLIA Kit for Cyclin D1 (CCND1) CLIA assay for Antigen Detection
ELW225Hu01 ELISA Kit for Cyclin D1 (CCND1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW225Mu01 Recombinant Cyclin D1 (CCND1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW225Mu01 Monoclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IP.
PAW225Mu01 Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IF.
Assay Kits CLW225Mu01 CLIA Kit for Cyclin D1 (CCND1) CLIA assay for Antigen Detection
ELW225Mu01 ELISA Kit for Cyclin D1 (CCND1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW225Ra01 Recombinant Cyclin D1 (CCND1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW225Ra01 Monoclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IP.
PAW225Ra01 Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IF.
Assay Kits CLW225Ra01 CLIA Kit for Cyclin D1 (CCND1) CLIA assay for Antigen Detection
ELW225Ra01 ELISA Kit for Cyclin D1 (CCND1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW225Ca01 Recombinant Cyclin D1 (CCND1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW225Ca01 Monoclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IP.
PAW225Ca01 Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IF.
Assay Kits CLW225Ca01 CLIA Kit for Cyclin D1 (CCND1) CLIA assay for Antigen Detection
ELW225Ca01 ELISA Kit for Cyclin D1 (CCND1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW225Po01 Recombinant Cyclin D1 (CCND1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW225Po01 Monoclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IP.
PAW225Po01 Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IF.
Assay Kits CLW225Po01 CLIA Kit for Cyclin D1 (CCND1) CLIA assay for Antigen Detection
ELW225Po01 ELISA Kit for Cyclin D1 (CCND1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW225Bo01 Recombinant Cyclin D1 (CCND1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW225Bo01 Monoclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IP.
PAW225Bo01 Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IF.
Assay Kits CLW225Bo01 CLIA Kit for Cyclin D1 (CCND1) CLIA assay for Antigen Detection
ELW225Bo01 ELISA Kit for Cyclin D1 (CCND1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW225Rb01 Recombinant Cyclin D1 (CCND1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW225Rb01 Monoclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IP.
PAW225Rb01 Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IF.
Assay Kits CLW225Rb01 CLIA Kit for Cyclin D1 (CCND1) CLIA assay for Antigen Detection
ELW225Rb01 ELISA Kit for Cyclin D1 (CCND1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW225Mo01 Recombinant Cyclin D1 (CCND1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW225Mo01 Monoclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IP.
PAW225Mo01 Polyclonal Antibody to Cyclin D1 (CCND1) WB; IHC; ICC; IF.
Assay Kits CLW225Mo01 CLIA Kit for Cyclin D1 (CCND1) CLIA assay for Antigen Detection
ELW225Mo01 ELISA Kit for Cyclin D1 (CCND1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A novel cyclin encoded by a bcl1-linked candidate oncogene."
Nature 350:512-515(1991) [PubMed] [Europe PMC] [Abstract]

"Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast."
Cell 66:1197-1206(1991) [PubMed] [Europe PMC] [Abstract]

"Human D-type cyclin."
Cell 65:691-699(1991) [PubMed] [Europe PMC] [Abstract]

"Characterization of a candidate bcl-1 gene."
Mol. Cell. Biol. 11:4846-4853(1991) [PubMed] [Europe PMC] [Abstract]

"Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias."
Blood 83:3689-3696(1994) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint."
Genes Chromosomes Cancer 7:89-95(1993) [PubMed] [Europe PMC] [Abstract]

"CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1."
Oncogene 9:71-79(1994) [PubMed] [Europe PMC] [Abstract]

"Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines."
Blood 88:674-681(1996) [PubMed] [Europe PMC] [Abstract]

"New functional activities for the p21 family of CDK inhibitors."
Genes Dev. 11:847-862(1997) [PubMed] [Europe PMC] [Abstract]

"Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286."
J. Biol. Chem. 275:12074-12079(2000) [PubMed] [Europe PMC] [Abstract]

"Cyclin-dependent kinases regulate the antiproliferative function of Smads."
Nature 430:226-231(2004) [PubMed] [Europe PMC] [Abstract]

"INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases."
Biochem. J. 397:169-177(2006) [PubMed] [Europe PMC] [Abstract]

"Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription."
J. Endocrinol. 198:29-39(2008) [PubMed] [Europe PMC] [Abstract]

"Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest."
J. Biol. Chem. 284:5574-5581(2009) [PubMed] [Europe PMC] [Abstract]

"Suppression of cancer cell growth by promoting cyclin D1 degradation."
Mol. Cell 36:469-476(2009) [PubMed] [Europe PMC] [Abstract]

"F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage."
Nature 459:722-725(2009) [PubMed] [Europe PMC] [Abstract]

"NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor."
Cell Cycle 10:3284-3299(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human CDK4 in complex with a D-type cyclin."
Proc. Natl. Acad. Sci. U.S.A. 106:4166-4170(2009) [PubMed] [Europe PMC] [Abstract]