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Cyclin D2 (CCND2)
Cyclin D2 (CCND2)
CCN-D2; G1/S-Specific Cyclin-D2
Cyclin D2 is a protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
W224Hu01
Recombinant Cyclin D2 (CCND2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cyclin D2 (CCND2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cyclin D2 (CCND2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry;ICC/IF
Assay Kits
KEW224Hu
ELISA Kit for Cyclin D2 (CCND2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cyclin D2 (CCND2) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cyclin D2 (CCND2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cyclin D2 (CCND2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
PW224Mu01
Polyclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cyclin D2 (CCND2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cyclin D2 (CCND2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cyclin D2 (CCND2) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cyclin D2 (CCND2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cyclin D2 (CCND2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cyclin D2 (CCND2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cyclin D2 (CCND2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cyclin D2 (CCND2) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cyclin D2 (CCND2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cyclin D2 (CCND2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cyclin D2 (CCND2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cyclin D2 (CCND2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cyclin D2 (CCND2) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cyclin D2 (CCND2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cyclin D2 (CCND2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cyclin D2 (CCND2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cyclin D2 (CCND2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cyclin D2 (CCND2) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cyclin D2 (CCND2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cyclin D2 (CCND2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cyclin D2 (CCND2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cyclin D2 (CCND2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cyclin D2 (CCND2) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cyclin D2 (CCND2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cyclin D2 (CCND2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cyclin D2 (CCND2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cyclin D2 (CCND2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cyclin D2 (CCND2) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cyclin D2 (CCND2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cyclin D2 (CCND2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cyclin D2 (CCND2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cyclin D2 (CCND2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cyclin D2 (CCND2) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cyclin D2 (CCND2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cyclin D2 (CCND2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cyclin D2 (CCND2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cyclin D2 (CCND2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cyclin D2 (CCND2) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cyclin D2 (CCND2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cyclin D2 (CCND2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cyclin D2 (CCND2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cyclin D2 (CCND2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cyclin D2 (CCND2) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cyclin D2 (CCND2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cyclin D2 (CCND2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cyclin D2 (CCND2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cyclin D2 (CCND2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cyclin D2 (CCND2) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cyclin D2 (CCND2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cyclin D2 (CCND2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cyclin D2 (CCND2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cyclin D2 (CCND2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cyclin D2 (CCND2) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cyclin D2 (CCND2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cyclin D2 (CCND2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cyclin D2 (CCND2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cyclin D2 (CCND2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cyclin D2 (CCND2) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cyclin D2 (CCND2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cyclin D2 (CCND2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cyclin D2 (CCND2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cyclin D2 (CCND2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cyclin D2 (CCND2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cyclin D2 (CCND2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cyclin D2 (CCND2) CLIA assay for Antigen Detection
Reference
"Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins." Genomics 13:575-584(1992) [PubMed ] [Europe PMC ] [Abstract ]
"Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines." PubMed ] [Europe PMC ] [Abstract ]
"Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed ] [Europe PMC ] [Abstract ]
"The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Genomic organization, chromosomal localization, and independent expression of human cyclin D genes." Genomics 13:565-574(1992) [PubMed ] [Europe PMC ] [Abstract ]
"Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition." Cell Struct. Funct. 33:171-183(2008) [PubMed ] [Europe PMC ] [Abstract ]
"Human and mouse cyclin D2 splice variants: transforming activity and subcellular localization." Oncogene 27:1253-1262(2008) [PubMed ] [Europe PMC ] [Abstract ]
"F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation." Blood 119:3132-3141(2012) [PubMed ] [Europe PMC ] [Abstract ]
"De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome." Nat. Genet. 46:510-515(2014) [PubMed ] [Europe PMC ] [Abstract ]
