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Pyruvate Kinase, Muscle (PKM2)

M2PK; PKM; M2-PK; PKM1; CTHBP; OIP3; PK3; PKM; TCB; THBP1; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; Cytosolic thyroid hormone-binding protein

Pyruvate Kinase M2 (M2-PK) is strongly overexpressed in a metabolic state specific for a variety of tumor cells. Recent reports indicate that Tumor M2-PK is a marker for renal cell carcinoma and. lung cancer. It has also been investigated in. pancreatic cancer and gastric cancer with promising results.

M2-PK is encoded by the gene PKM2 which does also encode for the pyruvate kinase isoenzyme type M1 (PKM1 or M1-PK). The M-gene consists of 12 exons and 11 introns. PKM1 and PKM2 are different splicing products of the M-gene (exon 9 for PKM1 and exon 10 for PKM2) and solely differ in 23 amino acids within a 56 amino acid stretch (aa 378-434) at their carboxy terminus.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W222Hu01 Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
PW222Hu02 Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits KEW222Hu ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W222Mu01 Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
PW222Mu02 Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits KEW222Mu ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W222Ra01 Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies MW222Ra21 Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits KEW222Ra ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection

Reference

"Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma."
Gene 73:509-516(1988) [PubMed] [Europe PMC] [Abstract]

"Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase."
Proc. Natl. Acad. Sci. U.S.A. 86:7861-7865(1989) [PubMed] [Europe PMC] [Abstract]

Erratum
Proc. Natl. Acad. Sci. U.S.A. 87:1625-1625(1990)

"Isolation and characterization of the human pyruvate kinase M gene."
Eur. J. Biochem. 198:101-106(1991) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]