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Pyruvate Kinase, Muscle (PKM2)
Pyruvate Kinase, Muscle (PKM2)
M2PK; PKM; M2-PK; PKM1; CTHBP; OIP3; PK3; PKM; TCB; THBP1; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; Cytosolic thyroid hormone-binding protein
Pyruvate Kinase M2 (M2-PK) is strongly overexpressed in a metabolic state specific for a variety of tumor cells. Recent reports indicate that Tumor M2-PK is a marker for renal cell carcinoma and. lung cancer. It has also been investigated in. pancreatic cancer and gastric cancer with promising results.
M2-PK is encoded by the gene PKM2 which does also encode for the pyruvate kinase isoenzyme type M1 (PKM1 or M1-PK). The M-gene consists of 12 exons and 11 introns. PKM1 and PKM2 are different splicing products of the M-gene (exon 9 for PKM1 and exon 10 for PKM2) and solely differ in 23 amino acids within a 56 amino acid stretch (aa 378-434) at their carboxy terminus.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
W222Hu01
Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
PW222Hu02
Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits
KEW222Hu
ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
W222Mu01
Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
PW222Mu02
Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits
KEW222Mu
ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
W222Ra01
Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies
MW222Ra21
Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits
KEW222Ra
ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Pyruvate Kinase, Muscle (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Pyruvate Kinase, Muscle (PKM2) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Pyruvate Kinase, Muscle (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Pyruvate Kinase, Muscle (PKM2) CLIA assay for Antigen Detection
Reference
"Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma." Gene 73:509-516(1988) [PubMed ] [Europe PMC ] [Abstract ]
"Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase." Proc. Natl. Acad. Sci. U.S.A. 86:7861-7865(1989) [PubMed ] [Europe PMC ] [Abstract ]
Erratum Proc. Natl. Acad. Sci. U.S.A. 87:1625-1625(1990)
"Isolation and characterization of the human pyruvate kinase M gene." Eur. J. Biochem. 198:101-106(1991) [PubMed ] [Europe PMC ] [Abstract ]
"Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]