Granzyme B (GZMB)
GZM-B; HLP; CTLA1; CCPI; CGL1; CSP-B; CSPB; CTSGL1; SECT; Granzyme 2; Cytotoxic T-Lymphocyte-Associated Serine Esterase 1; Fragmentin 2; Cytotoxic Serine Protease B
Granzymes are serine proteases that are released by cytoplasmic granules within cytotoxic T cells and natural killer cells. Granzyme B is an important mediator of cytotoxic lymphocyte granule-induced death of target cells, accomplishing this through cleavage of Bid and cleavage and activation of caspases as well as direct cleavage of downstream substrates.
The serine proteinase GZMB is crucial for the rapid induction of target cell apoptosis by cytotoxic T cells. GZMB enters cells in a perforin-independent manner, predicting the existence of a cell surface receptor(s). Motyka et al. (2000) presented evidence that this receptor is the cation-independent mannose 6-phosphate receptor (CIMPR), also called IGF2R. Inhibition of the GZMB-IGF2R interaction prevented GZMB cell surface binding, uptake, and the induction of apoptosis.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW210Hu01 | Recombinant Granzyme B (GZMB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW210Hu01 | Monoclonal Antibody to Granzyme B (GZMB) | WB; IHC; ICC; IP. |
| PAW210Hu01 | Polyclonal Antibody to Granzyme B (GZMB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW210Hu01 | CLIA Kit for Granzyme B (GZMB) | CLIA assay for Antigen Detection |
| ELW210Hu01 | ELISA Kit for Granzyme B (GZMB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW210Mu01 | Recombinant Granzyme B (GZMB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW210Mu01 | Monoclonal Antibody to Granzyme B (GZMB) | WB; IHC; ICC; IP. |
| PAW210Mu01 | Polyclonal Antibody to Granzyme B (GZMB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW210Mu01 | CLIA Kit for Granzyme B (GZMB) | CLIA assay for Antigen Detection |
| ELW210Mu01 | ELISA Kit for Granzyme B (GZMB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW210Ra01 | Recombinant Granzyme B (GZMB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW210Ra01 | Monoclonal Antibody to Granzyme B (GZMB) | WB; IHC; ICC; IP. |
| PAW210Ra01 | Polyclonal Antibody to Granzyme B (GZMB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW210Ra01 | CLIA Kit for Granzyme B (GZMB) | CLIA assay for Antigen Detection |
| ELW210Ra01 | ELISA Kit for Granzyme B (GZMB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW210Ca01 | Recombinant Granzyme B (GZMB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW210Ca01 | Monoclonal Antibody to Granzyme B (GZMB) | WB; IHC; ICC; IP. |
| PAW210Ca01 | Polyclonal Antibody to Granzyme B (GZMB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW210Ca01 | CLIA Kit for Granzyme B (GZMB) | CLIA assay for Antigen Detection |
| ELW210Ca01 | ELISA Kit for Granzyme B (GZMB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW210Po01 | Recombinant Granzyme B (GZMB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW210Po01 | Monoclonal Antibody to Granzyme B (GZMB) | WB; IHC; ICC; IP. |
| PAW210Po01 | Polyclonal Antibody to Granzyme B (GZMB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW210Po01 | CLIA Kit for Granzyme B (GZMB) | CLIA assay for Antigen Detection |
| ELW210Po01 | ELISA Kit for Granzyme B (GZMB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW210Bo01 | Recombinant Granzyme B (GZMB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW210Bo01 | Monoclonal Antibody to Granzyme B (GZMB) | WB; IHC; ICC; IP. |
| PAW210Bo01 | Polyclonal Antibody to Granzyme B (GZMB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW210Bo01 | CLIA Kit for Granzyme B (GZMB) | CLIA assay for Antigen Detection |
| ELW210Bo01 | ELISA Kit for Granzyme B (GZMB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW210Rb01 | Recombinant Granzyme B (GZMB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW210Rb01 | Monoclonal Antibody to Granzyme B (GZMB) | WB; IHC; ICC; IP. |
| PAW210Rb01 | Polyclonal Antibody to Granzyme B (GZMB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW210Rb01 | CLIA Kit for Granzyme B (GZMB) | CLIA assay for Antigen Detection |
| ELW210Rb01 | ELISA Kit for Granzyme B (GZMB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW210Mo01 | Recombinant Granzyme B (GZMB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW210Mo01 | Monoclonal Antibody to Granzyme B (GZMB) | WB; IHC; ICC; IP. |
| PAW210Mo01 | Polyclonal Antibody to Granzyme B (GZMB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW210Mo01 | CLIA Kit for Granzyme B (GZMB) | CLIA assay for Antigen Detection |
| ELW210Mo01 | ELISA Kit for Granzyme B (GZMB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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"Structure and differential mechanisms of regulation of expression of a serine esterase gene in activated human T lymphocytes."
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"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
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"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
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Biol. Chem. 381:1203-1214(2000) [PubMed] [Europe PMC] [Abstract]
"The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1."
Chem. Biol. 8:357-368(2001) [PubMed] [Europe PMC] [Abstract]
"Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population."
J. Hum. Genet. 48:249-270(2003) [PubMed] [Europe PMC] [Abstract]