Neuroglobin (NGB)
Neuroglobin is a newly discovered member of the hemoglobin superfamily that is primarily expressed in the brain of humans and other vertebrates. It is an O2-binding protein localized to cerebral neurons of vertebrates, including humans. Its physiological role is unknown but, like hemoglobin, myoglobin, and cytoglobin/histoglobin, it may transport O2, detoxify reactive oxygen species, or serve as a hypoxia sensor.Neuroglobin is a member of the vertebrate globin family involved in cellular oxygen homeostasis. It is an intracellular hemoprotein expressed in the central and peripheral nervous system, cerebrospinal fluid, retina and endocrine tissues. Italian researchers suggest that neuroglobin is more likely to usher in nitric oxide to protect neuron survival and recovery in areas where oxygen supply is reduced.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW204Hu01 | Recombinant Neuroglobin (NGB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW204Hu01 | Monoclonal Antibody to Neuroglobin (NGB) | WB; IHC; ICC; IP. |
| PAW204Hu01 | Polyclonal Antibody to Neuroglobin (NGB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW204Hu01 | CLIA Kit for Neuroglobin (NGB) | CLIA assay for Antigen Detection |
| ELW204Hu01 | ELISA Kit for Neuroglobin (NGB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW204Mu01 | Recombinant Neuroglobin (NGB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW204Mu01 | Monoclonal Antibody to Neuroglobin (NGB) | WB; IHC; ICC; IP. |
| PAW204Mu01 | Polyclonal Antibody to Neuroglobin (NGB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW204Mu01 | CLIA Kit for Neuroglobin (NGB) | CLIA assay for Antigen Detection |
| ELW204Mu01 | ELISA Kit for Neuroglobin (NGB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW204Ra01 | Recombinant Neuroglobin (NGB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW204Ra01 | Monoclonal Antibody to Neuroglobin (NGB) | WB; IHC; ICC; IP. |
| PAW204Ra01 | Polyclonal Antibody to Neuroglobin (NGB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW204Ra01 | CLIA Kit for Neuroglobin (NGB) | CLIA assay for Antigen Detection |
| ELW204Ra01 | ELISA Kit for Neuroglobin (NGB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW204Ca01 | Recombinant Neuroglobin (NGB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW204Ca01 | Monoclonal Antibody to Neuroglobin (NGB) | WB; IHC; ICC; IP. |
| PAW204Ca01 | Polyclonal Antibody to Neuroglobin (NGB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW204Ca01 | CLIA Kit for Neuroglobin (NGB) | CLIA assay for Antigen Detection |
| ELW204Ca01 | ELISA Kit for Neuroglobin (NGB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW204Po01 | Recombinant Neuroglobin (NGB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW204Po01 | Monoclonal Antibody to Neuroglobin (NGB) | WB; IHC; ICC; IP. |
| PAW204Po01 | Polyclonal Antibody to Neuroglobin (NGB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW204Po01 | CLIA Kit for Neuroglobin (NGB) | CLIA assay for Antigen Detection |
| ELW204Po01 | ELISA Kit for Neuroglobin (NGB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW204Bo01 | Recombinant Neuroglobin (NGB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW204Bo01 | Monoclonal Antibody to Neuroglobin (NGB) | WB; IHC; ICC; IP. |
| PAW204Bo01 | Polyclonal Antibody to Neuroglobin (NGB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW204Bo01 | CLIA Kit for Neuroglobin (NGB) | CLIA assay for Antigen Detection |
| ELW204Bo01 | ELISA Kit for Neuroglobin (NGB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW204Rb01 | Recombinant Neuroglobin (NGB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW204Rb01 | Monoclonal Antibody to Neuroglobin (NGB) | WB; IHC; ICC; IP. |
| PAW204Rb01 | Polyclonal Antibody to Neuroglobin (NGB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW204Rb01 | CLIA Kit for Neuroglobin (NGB) | CLIA assay for Antigen Detection |
| ELW204Rb01 | ELISA Kit for Neuroglobin (NGB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW204Mo01 | Recombinant Neuroglobin (NGB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW204Mo01 | Monoclonal Antibody to Neuroglobin (NGB) | WB; IHC; ICC; IP. |
| PAW204Mo01 | Polyclonal Antibody to Neuroglobin (NGB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW204Mo01 | CLIA Kit for Neuroglobin (NGB) | CLIA assay for Antigen Detection |
| ELW204Mo01 | ELISA Kit for Neuroglobin (NGB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A vertebrate globin expressed in the brain."
Nature 407:520-522(2000) [PubMed] [Europe PMC] [Abstract]
"Full-length cDNA cloning of human neuroglobin and tissue expression of rat neuroglobin."
Biochem. Biophys. Res. Commun. 290:1411-1419(2002) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family."
J. Biol. Chem. 276:38949-38955(2001) [PubMed] [Europe PMC] [Abstract]
"Coupling of the heme and an internal disulfide bond in human neuroglobin."
Micron 35:59-62(2004) [PubMed] [Europe PMC] [Abstract]
"Zebrafish neuroglobin is a cell-membrane-penetrating globin."
Biochemistry 47:5266-5270(2008) [PubMed] [Europe PMC] [Abstract]
"A role for human neuroglobin in apoptosis."
IUBMB Life 62:878-885(2010) [PubMed] [Europe PMC] [Abstract]
"Human neuroglobin functions as a redox-regulated nitrite reductase."
J. Biol. Chem. 286:18277-18289(2011) [PubMed] [Europe PMC] [Abstract]
"14-3-3 binding and phosphorylation of neuroglobin during hypoxia modulate six-to-five heme pocket coordination and rate of nitrite reduction to nitric oxide."
J. Biol. Chem. 286:42679-42689(2011) [PubMed] [Europe PMC] [Abstract]
"Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity."
Structure 11:1087-1095(2003) [PubMed] [Europe PMC] [Abstract]