Diamine Oxidase (DAO)
AOC1; ABP1; KAO; Histaminase; Kidney amine oxidase; Amiloride Binding Protein 1; Amiloride-sensitive amine oxidase; Amine oxidase copper domain-containing protein 1
On the basis of its primary structure, the amiloride-binding protein (EC 1.4.3.6) is 713 amino acids long, with a 19-amino acid signal peptide. Expressed in cultured cells, the mRNA yields a glycoprotein that binds amiloride and amiloride analogs with affinities similar to the amiloride receptor associated with the apical Na+ channel in pig kidney membranes and is immunoprecipitated with monoclonal antibodies raised against pig kidney amiloride-binding protein. Barbry et al. (1990) pointed out that amiloride-sensitive Na+ channels are also present in airway epithelia, where they play an important role in fluid secretion. Amiloride inhibits the excessive absorption of Na+ and liquid that takes place in airway epithelia of patients with cystic fibrosis, and amiloride aerosol therapy has been tried for the treatment of lung disease in CF.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW155Hu01 | Recombinant Diamine Oxidase (DAO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW155Hu01 | Monoclonal Antibody to Diamine Oxidase (DAO) | WB; IHC; ICC; IP. |
| PAW155Hu01 | Polyclonal Antibody to Diamine Oxidase (DAO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW155Hu01 | CLIA Kit for Diamine Oxidase (DAO) | CLIA assay for Antigen Detection |
| ELW155Hu01 | ELISA Kit for Diamine Oxidase (DAO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW155Mu01 | Recombinant Diamine Oxidase (DAO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW155Mu01 | Monoclonal Antibody to Diamine Oxidase (DAO) | WB; IHC; ICC; IP. |
| PAW155Mu01 | Polyclonal Antibody to Diamine Oxidase (DAO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW155Mu01 | CLIA Kit for Diamine Oxidase (DAO) | CLIA assay for Antigen Detection |
| ELW155Mu01 | ELISA Kit for Diamine Oxidase (DAO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW155Ra01 | Recombinant Diamine Oxidase (DAO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW155Ra01 | Monoclonal Antibody to Diamine Oxidase (DAO) | WB; IHC; ICC; IP. |
| PAW155Ra01 | Polyclonal Antibody to Diamine Oxidase (DAO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW155Ra01 | CLIA Kit for Diamine Oxidase (DAO) | CLIA assay for Antigen Detection |
| ELW155Ra01 | ELISA Kit for Diamine Oxidase (DAO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW155Ca01 | Recombinant Diamine Oxidase (DAO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW155Ca01 | Monoclonal Antibody to Diamine Oxidase (DAO) | WB; IHC; ICC; IP. |
| PAW155Ca01 | Polyclonal Antibody to Diamine Oxidase (DAO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW155Ca01 | CLIA Kit for Diamine Oxidase (DAO) | CLIA assay for Antigen Detection |
| ELW155Ca01 | ELISA Kit for Diamine Oxidase (DAO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW155Po01 | Recombinant Diamine Oxidase (DAO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW155Po01 | Monoclonal Antibody to Diamine Oxidase (DAO) | WB; IHC; ICC; IP. |
| PAW155Po01 | Polyclonal Antibody to Diamine Oxidase (DAO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW155Po01 | CLIA Kit for Diamine Oxidase (DAO) | CLIA assay for Antigen Detection |
| ELW155Po01 | ELISA Kit for Diamine Oxidase (DAO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW155Bo01 | Recombinant Diamine Oxidase (DAO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW155Bo01 | Monoclonal Antibody to Diamine Oxidase (DAO) | WB; IHC; ICC; IP. |
| PAW155Bo01 | Polyclonal Antibody to Diamine Oxidase (DAO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW155Bo01 | CLIA Kit for Diamine Oxidase (DAO) | CLIA assay for Antigen Detection |
| ELW155Bo01 | ELISA Kit for Diamine Oxidase (DAO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW155Rb01 | Recombinant Diamine Oxidase (DAO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW155Rb01 | Monoclonal Antibody to Diamine Oxidase (DAO) | WB; IHC; ICC; IP. |
| PAW155Rb01 | Polyclonal Antibody to Diamine Oxidase (DAO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW155Rb01 | CLIA Kit for Diamine Oxidase (DAO) | CLIA assay for Antigen Detection |
| ELW155Rb01 | ELISA Kit for Diamine Oxidase (DAO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW155Mo01 | Recombinant Diamine Oxidase (DAO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW155Mo01 | Monoclonal Antibody to Diamine Oxidase (DAO) | WB; IHC; ICC; IP. |
| PAW155Mo01 | Polyclonal Antibody to Diamine Oxidase (DAO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW155Mo01 | CLIA Kit for Diamine Oxidase (DAO) | CLIA assay for Antigen Detection |
| ELW155Mo01 | ELISA Kit for Diamine Oxidase (DAO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human kidney amiloride-binding protein: cDNA structure and functional expression."
Proc. Natl. Acad. Sci. U.S.A. 87:7347-7351(1990) [PubMed] [Europe PMC] [Abstract]
"The human gene for diamine oxidase, an amiloride binding protein. Molecular cloning, sequencing, and characterization of the promoter."
J. Biol. Chem. 269:14484-14489(1994) [PubMed] [Europe PMC] [Abstract]
"cDNA sequences of variant forms of human placenta diamine oxidase."
Biochem. Genet. 33:261-268(1995) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues."
J. Biol. Chem. 269:9921-9925(1994) [PubMed] [Europe PMC] [Abstract]
"Structure and inhibition of human diamine oxidase."
Biochemistry 48:9810-9822(2009) [PubMed] [Europe PMC] [Abstract]