Glutathione S Transferase Mu 1 (GSTm1)

GST-M1; GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4; GTM1; H-B; MU1; GST HB subunit 4

SPN	W153
HGNC	4632
MGI	95861
PubMed	12771031
RGD	2755
UniProt	P09488
Wiki	GSTP1

Strange et al. (1984) reported that GST1 is easily demonstrable in adult liver, kidney, adrenal and stomach but is only weakly expressed in skeletal and cardiac muscle and not at all in fetal liver, fibroblasts, erythrocytes, lymphocytes and platelets. GST2 is not detectable in the last 4 tissues but is found in many other tissues including fetal liver. GST3 (GSTP1) is found in every tissue except adult liver.By in situ hybridization, DeJong et al. (1988) mapped the GST1 gene to chromosome 1p31. Zhong et al. (1992) used oligonucleotide primers specific for intron 5 sequences in the GSTM1 gene to amplify a unique 718-bp fragment. They confirmed the assignment to 1p by analysis of DNA from a panel of somatic cell hybrids and refined the localization to 1p13 by linkage analysis in 3-generation CEPH families.

Reference

"The human liver glutathione S-transferase gene superfamily: expression and chromosome mapping of an Hb subunit cDNA."
Nucleic Acids Res. 16:8541-8554(1988) [PubMed] [Europe PMC] [Abstract]

"Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion."
Proc. Natl. Acad. Sci. U.S.A. 85:7293-7297(1988) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Deduced amino acid sequence, gene structure and chromosomal location of a novel human class Mu glutathione S-transferase, GSTM4."
Biochem. J. 291:41-50(1993) [PubMed] [Europe PMC] [Abstract]

"Immunochemical evidence for the occurrence of Mu class glutathione S-transferase in human fetal livers."
J. Biochem. 116:315-320(1994) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of glutathione transferases with an activity toward nitroglycerin from human aorta and heart. Multiplicity of the human class Mu forms."
J. Biol. Chem. 265:7150-7157(1990) [PubMed] [Europe PMC] [Abstract]

"Structural evidence for three different types of glutathione transferase in human tissues."
FEBS Lett. 182:319-322(1985) [PubMed] [Europe PMC] [Abstract]

"Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties."
Proc. Natl. Acad. Sci. U.S.A. 82:7202-7206(1985) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of human muscle glutathione S-transferases: evidence that glutathione S-transferase zeta corresponds to a locus distinct from GST1, GST2, and GST3."
Arch. Biochem. Biophys. 285:64-73(1991) [PubMed] [Europe PMC] [Abstract]

"Gender related differences in the expression and characteristics of glutathione S-transferases of human colon."
Biochim. Biophys. Acta 1171:19-26(1992) [PubMed] [Europe PMC] [Abstract]

"Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping."
Electrophoresis 21:3785-3796(2000) [PubMed] [Europe PMC] [Abstract]

"GST1 gene deletion determined by polymerase chain reaction."
Nucleic Acids Res. 18:3670-3670(1990) [PubMed] [Europe PMC] [Abstract]

"Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13."
Am. J. Hum. Genet. 53:220-233(1993) [PubMed] [Europe PMC] [Abstract]

"Functions of His107 in the catalytic mechanism of human glutathione S-transferase hGSTM1a-1a."
Biochemistry 38:1193-1202(1999) [PubMed] [Europe PMC] [Abstract]

"Transition state model and mechanism of nucleophilic aromatic substitution reactions catalyzed by human glutathione S-transferase M1a-1a."
Biochemistry 45:3852-3862(2006) [PubMed] [Europe PMC] [Abstract]