Glutathione S Transferase Alpha 4 (GSTa4)

GST-A4; GSTA4-4; GTA4

SPN	W152
HGNC	4629
MGI	1309515
PubMed	18767114
RGD	1309970
UniProt	O15217
Wiki	GSTA4

Glutathione S Transferase Alpha 4 is a glutathione S-tranferase belonging to the alpha class.GSTA4 shows very high activity with reactive carbonyl compounds such as alk-2-enals.GSTA4 is highly effective in catalyzing the conjugate addition of reduced glutathione to 4-hydroxynonenal, an important product of peroxidative degradation of arachidonic acid and a commonly used biomarker for oxidative damage in tissue.Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis hence reduced expression of the GSTA4 enzyme may have pathophysiological consequences. The expression of this gene is decreased drastically among burn and trauma victims.

Reference

"Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation."
Biochem. J. 330:175-179(1998) [PubMed] [Europe PMC] [Abstract]

"Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4."
Biochem. J. 330:827-831(1998) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel human glutathione S-transferase using bioinformatics."
Arch. Biochem. Biophys. 352:306-313(1998) [PubMed] [Europe PMC] [Abstract]

"Genomic organization, 5'-flanking region and chromosomal localization of the human glutathione transferase A4 gene."
Biochem. J. 336:437-442(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products."
J. Mol. Biol. 288:427-439(1999) [PubMed] [Europe PMC] [Abstract]

"Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal."
Biochemistry 49:1541-1548(2010) [PubMed] [Europe PMC] [Abstract]