Homing Associated Cell Adhesion Molecule (HCAM)

CDW44; CD44; CSPG8; ECMR-III; HCELL; IN; LHR; MC56; MDU2; MDU3; MIC4; MUTCH-I; Pgp1; Hematopoietic Cell E- And L-Selectin Ligand; Chondroitin Sulfate Proteoglycan 8

SPN	W142
HGNC	1681
MGI	88338
PubMed	12484499
RGD	2307
UniProt	P16070
Wiki	CD44

The CD44 protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. Splice variants of CD44 on colon cancer cells display the HCELL glycoform, which mediates binding to vascular E-selectin under hemodynamic flow conditions, a critical step in colon cancer metastasis. CD44 gene transcription is at least in part activated by beta-catenin and Wnt signalling.

Reference

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"The multispecific cell adhesion molecule CD44 is represented in reticulocyte cDNA."
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"The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells."
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"A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility."
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