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Coagulation Factor V (F5)

FV; FVL; PCCF; Proaccelerin; Labile Factor; Factor V Leiden; Accelerator Globulin; Activated protein C cofactor; Proaccelerin, labile factor

Factor V is an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. 

Factor 5 is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor. Deficiency leads to predisposition for hemorrhage, while some mutations (most notably factor V Leiden) predispose for thrombosis.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW137Hu01 Recombinant Coagulation Factor V (F5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW137Hu01 Monoclonal Antibody to Coagulation Factor V (F5) WB; IHC; ICC; IP.
PAW137Hu01 Polyclonal Antibody to Coagulation Factor V (F5) WB; IHC; ICC; IF.
Assay Kits CLW137Hu01 CLIA Kit for Coagulation Factor V (F5) CLIA assay for Antigen Detection
ELW137Hu01 ELISA Kit for Coagulation Factor V (F5) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW137Mu01 Recombinant Coagulation Factor V (F5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW137Mu01 Monoclonal Antibody to Coagulation Factor V (F5) WB; IHC; ICC; IP.
PAW137Mu01 Polyclonal Antibody to Coagulation Factor V (F5) WB; IHC; ICC; IF.
Assay Kits CLW137Mu01 CLIA Kit for Coagulation Factor V (F5) CLIA assay for Antigen Detection
ELW137Mu01 ELISA Kit for Coagulation Factor V (F5) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW137Ra01 Recombinant Coagulation Factor V (F5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW137Ra01 Monoclonal Antibody to Coagulation Factor V (F5) WB; IHC; ICC; IP.
PAW137Ra01 Polyclonal Antibody to Coagulation Factor V (F5) WB; IHC; ICC; IF.
Assay Kits CLW137Ra01 CLIA Kit for Coagulation Factor V (F5) CLIA assay for Antigen Detection
ELW137Ra01 ELISA Kit for Coagulation Factor V (F5) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW137Ca01 Recombinant Coagulation Factor V (F5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW137Ca01 Monoclonal Antibody to Coagulation Factor V (F5) WB; IHC; ICC; IP.
PAW137Ca01 Polyclonal Antibody to Coagulation Factor V (F5) WB; IHC; ICC; IF.
Assay Kits CLW137Ca01 CLIA Kit for Coagulation Factor V (F5) CLIA assay for Antigen Detection
ELW137Ca01 ELISA Kit for Coagulation Factor V (F5) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW137Po01 Recombinant Coagulation Factor V (F5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW137Po01 Monoclonal Antibody to Coagulation Factor V (F5) WB; IHC; ICC; IP.
PAW137Po01 Polyclonal Antibody to Coagulation Factor V (F5) WB; IHC; ICC; IF.
Assay Kits CLW137Po01 CLIA Kit for Coagulation Factor V (F5) CLIA assay for Antigen Detection
ELW137Po01 ELISA Kit for Coagulation Factor V (F5) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW137Bo01 Recombinant Coagulation Factor V (F5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW137Bo01 Monoclonal Antibody to Coagulation Factor V (F5) WB; IHC; ICC; IP.
PAW137Bo01 Polyclonal Antibody to Coagulation Factor V (F5) WB; IHC; ICC; IF.
Assay Kits CLW137Bo01 CLIA Kit for Coagulation Factor V (F5) CLIA assay for Antigen Detection
ELW137Bo01 ELISA Kit for Coagulation Factor V (F5) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW137Rb01 Recombinant Coagulation Factor V (F5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW137Rb01 Monoclonal Antibody to Coagulation Factor V (F5) WB; IHC; ICC; IP.
PAW137Rb01 Polyclonal Antibody to Coagulation Factor V (F5) WB; IHC; ICC; IF.
Assay Kits CLW137Rb01 CLIA Kit for Coagulation Factor V (F5) CLIA assay for Antigen Detection
ELW137Rb01 ELISA Kit for Coagulation Factor V (F5) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW137Mo01 Recombinant Coagulation Factor V (F5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW137Mo01 Monoclonal Antibody to Coagulation Factor V (F5) WB; IHC; ICC; IP.
PAW137Mo01 Polyclonal Antibody to Coagulation Factor V (F5) WB; IHC; ICC; IF.
Assay Kits CLW137Mo01 CLIA Kit for Coagulation Factor V (F5) CLIA assay for Antigen Detection
ELW137Mo01 ELISA Kit for Coagulation Factor V (F5) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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Erratum
Nat. Genet. 23:373-373(1999)

"Combinations of 4 mutations (FV R506Q, FV H1299R, FV Y1702C, PT 20210G/A) affecting the prothrombinase complex in a thrombophilic family."
Blood 96:1443-1448(2000) [PubMed] [Europe PMC] [Abstract]

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Blood 98:358-367(2001) [PubMed] [Europe PMC] [Abstract]

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