Membrane Protein, Palmitoylated 2 (MPP2)

DLG2; MAGUK P55 Subfamily Member 2; Discs Large,Homolog 2

SPN	W132
HGNC	7220
MGI	1858257
PubMed	10523841
RGD	620014
UniProt	Q14168
Wiki	MPP2

Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.The dlg-A protein had been shown to act as a tumor suppressor, and the other members of this family may be involved in signal transduction through specialized membrane domains with highly organized cytoskeletons and thus are potential tumor suppressors.

Reference

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Submitted (JAN-2008) to the PDB data bank