Mucin 5 Subtype B (MUC5B)
MUC5-B; MUC9; MG1; Oligomeric Mucus/Gel-Forming; Mucin 5,Subtype B,Tracheobronchial; Cervical mucin; High molecular weight salivary mucin MG1; Sublingual gland mucin
Mucins are high molecular mass, highly glycosylated macromolecules that are the major components of mucus secretions. MUC5B is a salivary mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva. It is composed of 14.9% protein, 78.1% carbohydrate, and 7% sulfate.Desseyn et al. isolated MUC5B genomic sequence. They found that the central exon encodes a predicted 3,570-amino acid peptide containing 19 subdomains that can be grouped into 4 larger composite units referred to as 'superrepeats'. Since MUC5B and the related proteins MUC2 and MUC5AC are clustered within chromosome 11p15.5, suggesting that they are members of a multigene family.Desseyn et al. reported that the region 3-prime of the large central exon of MUC5B is composed of 18 exons and spans about 10.7 kb.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW128Hu01 | Recombinant Mucin 5 Subtype B (MUC5B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW128Hu01 | Monoclonal Antibody to Mucin 5 Subtype B (MUC5B) | WB; IHC; ICC; IP. |
| PAW128Hu01 | Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW128Hu01 | CLIA Kit for Mucin 5 Subtype B (MUC5B) | CLIA assay for Antigen Detection |
| ELW128Hu01 | ELISA Kit for Mucin 5 Subtype B (MUC5B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW128Mu01 | Recombinant Mucin 5 Subtype B (MUC5B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW128Mu01 | Monoclonal Antibody to Mucin 5 Subtype B (MUC5B) | WB; IHC; ICC; IP. |
| PAW128Mu01 | Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW128Mu01 | CLIA Kit for Mucin 5 Subtype B (MUC5B) | CLIA assay for Antigen Detection |
| ELW128Mu01 | ELISA Kit for Mucin 5 Subtype B (MUC5B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW128Ra01 | Recombinant Mucin 5 Subtype B (MUC5B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW128Ra01 | Monoclonal Antibody to Mucin 5 Subtype B (MUC5B) | WB; IHC; ICC; IP. |
| PAW128Ra01 | Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW128Ra01 | CLIA Kit for Mucin 5 Subtype B (MUC5B) | CLIA assay for Antigen Detection |
| ELW128Ra01 | ELISA Kit for Mucin 5 Subtype B (MUC5B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW128Ca01 | Recombinant Mucin 5 Subtype B (MUC5B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW128Ca01 | Monoclonal Antibody to Mucin 5 Subtype B (MUC5B) | WB; IHC; ICC; IP. |
| PAW128Ca01 | Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW128Ca01 | CLIA Kit for Mucin 5 Subtype B (MUC5B) | CLIA assay for Antigen Detection |
| ELW128Ca01 | ELISA Kit for Mucin 5 Subtype B (MUC5B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW128Po01 | Recombinant Mucin 5 Subtype B (MUC5B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW128Po01 | Monoclonal Antibody to Mucin 5 Subtype B (MUC5B) | WB; IHC; ICC; IP. |
| PAW128Po01 | Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW128Po01 | CLIA Kit for Mucin 5 Subtype B (MUC5B) | CLIA assay for Antigen Detection |
| ELW128Po01 | ELISA Kit for Mucin 5 Subtype B (MUC5B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW128Bo01 | Recombinant Mucin 5 Subtype B (MUC5B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW128Bo01 | Monoclonal Antibody to Mucin 5 Subtype B (MUC5B) | WB; IHC; ICC; IP. |
| PAW128Bo01 | Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW128Bo01 | CLIA Kit for Mucin 5 Subtype B (MUC5B) | CLIA assay for Antigen Detection |
| ELW128Bo01 | ELISA Kit for Mucin 5 Subtype B (MUC5B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW128Rb01 | Recombinant Mucin 5 Subtype B (MUC5B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW128Rb01 | Monoclonal Antibody to Mucin 5 Subtype B (MUC5B) | WB; IHC; ICC; IP. |
| PAW128Rb01 | Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW128Rb01 | CLIA Kit for Mucin 5 Subtype B (MUC5B) | CLIA assay for Antigen Detection |
| ELW128Rb01 | ELISA Kit for Mucin 5 Subtype B (MUC5B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW128Mo01 | Recombinant Mucin 5 Subtype B (MUC5B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW128Mo01 | Monoclonal Antibody to Mucin 5 Subtype B (MUC5B) | WB; IHC; ICC; IP. |
| PAW128Mo01 | Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW128Mo01 | CLIA Kit for Mucin 5 Subtype B (MUC5B) | CLIA assay for Antigen Detection |
| ELW128Mo01 | ELISA Kit for Mucin 5 Subtype B (MUC5B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region."
Am. J. Respir. Cell Mol. Biol. 25:542-553(2001) [PubMed] [Europe PMC] [Abstract]
"The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions."
Biochem. Biophys. Res. Commun. 251:350-355(1998) [PubMed] [Europe PMC] [Abstract]
"Genomic organization of the human mucin gene MUC5B: cDNA and genomic sequences upstream of the large central exon."
J. Biol. Chem. 273:30157-30164(1998) [PubMed] [Europe PMC] [Abstract]
"Human mucin gene MUC5B, the 10.7 kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family."
J. Biol. Chem. 272:3168-3178(1997) [PubMed] [Europe PMC] [Abstract]
"Proteolytic fragmentation and peptide mapping of human carboxyamidomethylated tracheobronchial mucin."
J. Biol. Chem. 264:8193-8199(1989) [PubMed] [Europe PMC] [Abstract]
"Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B."
Glycobiology 7:413-419(1997) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B."
Biochem. J. 324:295-303(1997) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland."
Biochem. Biophys. Res. Commun. 217:1112-1119(1995) [PubMed] [Europe PMC] [Abstract]
"Genomic organization of the 3 region of the human MUC5B mucin."
J. Biol. Chem. 272:16873-16883(1997) [PubMed] [Europe PMC] [Abstract]
"In vivo glycosylation of mucin tandem repeats."
Glycobiology 11:459-471(2001) [PubMed] [Europe PMC] [Abstract]
"C-Mannosylation of MUC5AC and MUC5B Cys subdomains."
Glycobiology 14:325-337(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
"A common MUC5B promoter polymorphism and pulmonary fibrosis."
N. Engl. J. Med. 364:1503-1512(2011) [PubMed] [Europe PMC] [Abstract]
"A variant in the promoter of MUC5B and idiopathic pulmonary fibrosis."
N. Engl. J. Med. 364:1576-1577(2011) [PubMed] [Europe PMC] [Abstract]