TGF Beta Inducible Early Response Gene 1 (TIEG1)

KLF10; EGRA; TIEG; Krueppel-Like Factor 10; TGFB Inducible Early Growth Response; EGR-alpha; Transforming growth factor-beta-inducible early growth response protein 1

SPN	W124
HGNC	11810
MGI	1101353
PubMed	17729309
RGD	621652
UniProt	Q13118
Wiki	KLF10

Tachibana et al. characterized the expression and function in exocrine pancreatic epithelial cells of the TGF-beta-inducible early gene (TIEG), a Kruppel-like zinc finger transcription factor-encoding gene previously isolated from mesodermally derived osteoblastic cells by Subramaniam et al. Tachibana et al.  demonstrated that the gene is expressed in both acinar and ductular epithelial cell populations from the exocrine pancreas. In addition, they showed that the expression of TIEG is regulated by TGF-beta-1 (TGFB1) as an early response gene in pancreatic epithelial cell lines. Overexpression of TIEG in a TGF-beta-sensitive epithelial cell line was sufficient to induce apoptosis. Thus, Tachibana et al. concluded that TIEG plays a role in linking TGF-beta-mediated signaling cascades to the regulation of pancreatic epithelial cell growth.

Reference

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Mol. Endocrinol. 9:1610-1620(1995) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts."
Nucleic Acids Res. 23:4907-4912(1995) [PubMed] [Europe PMC] [Abstract]

"TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters."
Genomics 51:408-416(1998) [PubMed] [Europe PMC] [Abstract]

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J. Biol. Chem. 277:30754-30759(2002) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of a consensus DNA binding element for the zinc finger transcription factor TIEG/EGRalpha."
DNA Cell Biol. 22:187-199(2003) [PubMed] [Europe PMC] [Abstract]

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"Solution structure of the first and second ZF-C2H2 domains from human krueppel-like factor 10."
Submitted (APR-2008) to the PDB data bank