Heat Shock 27kDa Protein 1 (HSPB1)

HSP27; HSP-B1; CMT2F; HSP28; Hsp25; Heat Shock Protein 27; 28 kDa heat shock protein; Heat shock protein beta-1; Estrogen-regulated 24 kDa protein;

SPN	W119
HGNC	5246
MGI	96240
PubMed	12385642
RGD	61306
UniProt	P04792
Wiki	Hsp27

Heat shock protein (HSP) 27 is one of the small HSPs. Like other small heat shock proteins, HSP27 is regulated at both the transcriptional and posttranslational levels . In response to stress, the expression level of HSP27 increases several-fold to confer cellular resistance to the adverse environmental change.

HSP27 is phosphorylated at Ser15, Ser78 and Ser82 by MAPKAP kinase 2 as a result of the activation of the p38 MAP kinase pathway . Phosphorylation of HSP27 causes a change in its tertiary structure, which shifts from large homotypic multimers to dimers and monomers . It has been shown that phosphorylation and increased concentration of HSP27 modulates actin polymerization and reorganization .

Reference

"Sequence and organization of genes encoding the human 27 kDa heat shock protein."
Nucleic Acids Res. 14:4127-4145(1986) [PubMed] [Europe PMC] [Abstract]

"cDNA sequence of a human heat shock protein HSP27."
Nucleic Acids Res. 18:6457-6457(1990) [PubMed] [Europe PMC] [Abstract]

"Small heat shock protein 27 (HSP27) associates with tubulin/microtubules in HeLa cells."
Biochem. Biophys. Res. Commun. 271:164-169(2000) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of two related markers for common acute lymphoblastic leukemia as heat shock proteins."
J. Clin. Invest. 85:200-207(1990) [PubMed] [Europe PMC] [Abstract]